“…While promising, using reticulated platelets as a routine prognostic tool requires further research to establish optimal parameters and cutoff values as well as to understand how different antiplatelet therapies affect patients with elevated reticulated platelets. 79 Kawano et al 80 developed a new mouse model using BxPC-3 cells to study pancreatic cancer's effect on altered platelet function and arterial thrombosis. They found reduced platelet counts but elevated reticulated platelets suggesting enhanced clearance of activated platelets.…”