Reticular Perineurioma of the Hand: Diagnosis and Treatment of a Rare Case of Hand Mass

Zaugg, Patrice; Maeder, Benoît; Nobile, Antoine; Raffoul, Wassim; Bollmann, Christof; Summa, Pietro G. di

doi:10.1016/j.jhsa.2016.11.009

Cited by 3 publications

(3 citation statements)

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“…Occasionally, some cases exhibiting ossification foci, granular cell change, and Pacinian-like bodies have been described [ 58 , 59 ]. Apart from the classic type, soft tissue perineurioma may exhibit in at least two different histological variants, reticular and sclerosing perineurioma [ 60 , 61 , 62 , 63 ]. The former is characteristically composed of slender spindled cells, usually set in a myxo-edematous stroma showing cytoplasmic anastomosing processes, resulting in a reticular or lace-like appearance [ 60 , 61 ].…”

Section: Perineuriomasmentioning

confidence: 99%

“…Apart from the classic type, soft tissue perineurioma may exhibit in at least two different histological variants, reticular and sclerosing perineurioma [ 60 , 61 , 62 , 63 ]. The former is characteristically composed of slender spindled cells, usually set in a myxo-edematous stroma showing cytoplasmic anastomosing processes, resulting in a reticular or lace-like appearance [ 60 , 61 ]. Sclerosing perineurioma is an unusual variant, mainly occurring in young male adults and involving almost exclusively the superficial soft tissues of the hand.…”

Section: Perineuriomasmentioning

confidence: 99%

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Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

et al. 2022

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Peripheral nerve sheath tumors encompass a wide spectrum of lesions with different biological behavior, including both benign and malignant neoplasms as well as the recent diagnostic category, i.e., “atypical neurofibromatous neoplasm with uncertain biologic potential” to be used only for NF1 patients. Neurofibromas and schwannomas are benign Schwann-cell-derived peripheral nerve sheath tumors arising as isolated lesions or within the context of classical neurofibromatosis or schwannomatoses. Multiple tumors are a hallmark of neurofibromatosis type 1(NF1) and related forms, NF2-related-schwannomatosis (formerly NF2) or SMARCB1/LZTR1-related schwannomatoses. Perineuriomas are benign, mostly sporadic, peripheral nerve sheath tumors that show morphological, immunohistochemical, and ultrastructural features reminiscent of perineurial differentiation. Hybrid tumors exist, with the most common lesions represented by a variable mixture of neurofibromas, schwannomas, and perineuriomas. Conversely, malignant peripheral nerve sheath tumors are soft tissue sarcomas that may arise from a peripheral nerve or a pre-existing neurofibroma, and in about 50% of cases, these tumors are associated with NF1. The present review emphasizes the main clinicopathologic features of each pathological entity, focusing on the diagnostic clues and unusual morphological variants.

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Section: Perineuriomasmentioning

confidence: 99%

Section: Perineuriomasmentioning

confidence: 99%

Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update

et al. 2022

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“…As a result of its non-specific gross morphology, and various morphologic patterns, perineurioma is frequently confused with other more common tumors such as schwannoma, neurofibroma, giant tumor of tendon sheath, and fibromyxoid tumors. 5,6 On the hand, the most commonly reported benign tumors are ganglion cysts, giant cell tumor of the tendon sheath, and epidermoid cysts. 7 Although considered in our differential diagnoses, epithelioid sarcoma often has a very aggressive clinical course.…”

Section: Case Presentationmentioning

confidence: 99%

Microreticular perineurioma: A new morphological subtype of a rare entity

Salah

D'ardis

Enos³

et al. 2023

J Cutan Pathol

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Perineurioma is a benign peripheral nerve sheath tumor. Several subtypes have been described, including plexiform, reticular, and sclerosing. The reticular variant has been previously described as having a net or lace-like growth pattern consisting of large anastomosing cords of spindle-shaped cells. We report a case of an 11-year-old male who presented with a 2-year history of a slowly enlarging, tan-white lesion on the finger. Microscopically, the lesion consisted of cells with ovoid nuclei and delicate, elongate cytoplasmic processes, arranged in a microreticular pattern. The lesional cells were markedly positive for epithelial membrane antigen and claudin-1. Based on these features and the unusual morphology, the case was called a microreticular perineuroma. The patient underwent complete excision of the lesion with no recurrence 9 months after follow-up. To our knowledge, this is the first reported case of this morphologic variant. Awareness of this entity is important to avoid inappropriate management.

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