Reticular Drusen Associated with Geographic Atrophy in Age-Related Macular Degeneration

Schmitz-Valckenberg, Steffen; Alten, Florian; Steinberg, Julia S.; Jaffe, Glenn J.; Fleckenstein, Monika; Mukesh, Bickol N.; Hohman, Thomas C.; Holz, Frank G.

doi:10.1167/iovs.11-7235

Cited by 169 publications

(162 citation statements)

References 33 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Thereby, we probably did not diagnose some RPD if they were outside of the cube, because they are frequently located in the pericentral area and near the superior temporal vascular arcade. 4,13,20 According to the other studies, specificity was high with the four imaging modalities.…”

Section: Discussion Prevalencementioning

confidence: 78%

Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study

Chan

Cougnard‐Grégoire

Delyfer

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

57:3058-3065. DOI:10.1167/ iovs.16-19487 PURPOSE. To document reticular pseudodrusen (RPD) using multimodal imaging in French elderly subjects. METHODS.A total of 494 subjects (970 eyes) aged 77 years or more, from the Alienor study, were examined in 2011 and 2012. Reticular pseudodrusen were defined as definite if they were present with at least two imaging methods among color retinal photographs, macular cube (208 3 158) of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and infrared reflectance (IR). The Youden index was calculated as specificity þ sensitivity À 1.RESULTS. The prevalence of definite RPD was 13.4% and was higher among women (15.6%) than men (10.2%). It increased with age and reached almost 50% in subjects over 85 years. Infrared reflectance was the most sensitive technique (100%) and color fundus photography the least sensitive (34.5% at left eyes and 48.1% at right eyes). The best Youden index was obtained with IR (0.96 at both eyes) followed by SD-OCT (0.87 at right eye and 0.78 at left eye). Reticular pseudodrusen were present in 4.6% of eyes without AMD, 13.0% with early AMD1, 62.6% with early AMD2, 34.6% with atrophic AMD, and 8.1% with neovascular AMD. Reticular pseudodrusen were significantly associated with central and pericentral intermediate soft drusen (odds ratio [OR]: 2.14; 95% confidence interval [CI] ¼ 1.11-4.14 and OR: 1.49; 95% CI ¼ 1.16-1.90, respectively) and central large soft drusen (OR: 1.67; 95% CI ¼ 1.16-2.42).CONCLUSIONS. Using multimodal imaging, the prevalence of RPD appears higher than previously reported in studies based on retinal photography only. Reticular pseudodrusen frequently accompany other signs of AMD. Infrared reflectance and SD-OCT appear to be particularly relevant methods to diagnose RPD.

show abstract

Section: Discussion Prevalencementioning

confidence: 78%

Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study

Chan

Cougnard‐Grégoire

Delyfer

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Interestingly, it has been reported that both RDR lesions and GA presence are more prevalent in the superior macula. 26,29,30 However, a prospective longitudinal study will be required to establish a direct association. We observed, to the best of our knowledge for the first time, a relative sparing of RDR above and below the optic nerve head when RDR were located nasal to the optic disc.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of RDR in the entire GAP study population has been reported previously following a two-independent reader system with senior arbitration in case of discrepancy. 26 For FAF imaging, RDR had been found to be present in at least in one eye in 56% of subjects. A similar RDR detection rate of 52% (22 subjects) was found in the selected 42 subjects with complete follow-up.…”

Section: Methodsmentioning

confidence: 98%

Longitudinal Analysis of Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration

Steinberg

Auge

Jaffe

et al. 2013

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

Valckenberg S; the GAP Study Group. Longitudinal analysis of reticular drusen associated with geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013;54:4054-4060. DOI:10. 1167/iovs.12-11538 PURPOSE. To characterize longitudinal changes of reticular drusen (RDR) in subjects with geographic atrophy (GA) secondary to age-related macular degeneration in the multicenter, prospective natural history Geographic Atrophy Progression Study.METHODS. Three-field confocal scanning laser ophthalmoscopy fundus autofluorescence (cSLO FAF, excitation [exc.] ¼ 488 nm; emission [em.] 500-800 nm, Heidelberg Retina Angiograph/ Spectralis) of 44 eyes of 22 patients with RDR (median age 77.6 years; range, 61-90 years) at baseline were identified in the study population and included for further analysis. Two independent readers determined the presence, topographic distribution, and pattern of RDR at baseline and at 18 months. Furthermore, the convex hull of the extent of RDR as the minimum polygon encompassing the entire area of RDR involvement was quantified.RESULTS. RDR lesion boundaries were clearly detectable in all directions within three-field FAF composite images in 16 eyes of 10 patients at both baseline and final visits. Over time, RDRaffected retinal area and RDR density increased. Quantitative analysis showed a mean average RDR extent of 53.7 mm 2 (95% confidence interval [95% CI]; 40.7; 66.8) at baseline. The mean differences for intraobserver agreements were 2.4 mm 2 (95% CI; À0.1; 4.9) for reader 1 and À0.6 mm 2 (95% CI; À2.3; 1.1) for reader 2. The mean difference of interobserver agreement was 0.9 mm 2 (95% CI; À0.8; 2.7). A mean growth rate of the RDR extent within the three-field FAF composite image of 4.4 mm 2 /y (95% CI; 1.9; 6.9) was measured.CONCLUSIONS. In vivo cSLO FAF imaging allows for both qualitative and quantitative mapping of longitudinal changes of RDR areas within a relatively short time period. Continuous enlargement of the affected retinal area indicates disease progression with regard to this phenotypic characteristic associated with GA in AMD. Systematic recordings of RDR progression appears warranted in future natural history and interventional studies in dry AMD. (ClinicalTrials.gov number, NCT00599846.)

show abstract

“…3). 43,44 However, the importance of NIR imaging has not been validated in large studies, and this imaging modality currently remains a potentially valuable adjunct to blue-light FAF, especially for confirming or excluding involvement of the foveal center by the atrophic lesion.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

Multimodal Imaging of Nonneovascular Age-Related Macular Degeneration

Garrity

Sarraf

Freund

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Reticular Drusen Associated with Geographic Atrophy in Age-Related Macular Degeneration

Cited by 169 publications

References 33 publications

Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study

Multimodal Imaging of Reticular Pseudodrusen in a Population-Based Setting: The Alienor Study

Longitudinal Analysis of Reticular Drusen Associated With Geographic Atrophy in Age-Related Macular Degeneration

Multimodal Imaging of Nonneovascular Age-Related Macular Degeneration

Contact Info

Product

Resources

About