Reticular corneal epithelial edema with topical netarsudil

Parmar, DipaliP; Bhole, PradnyaK; Garde, PawanV

doi:10.4103/ojo.ojo_2_22

Cited by 1 publication

(1 citation statement)

References 10 publications

(26 reference statements)

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“…It is interesting to note that blepharitis is not a common adverse effect of netarsudil in contrast to ripasudil, and the reasons for this remain unclear. As with ripasudil, various studies reported the incidence of honeycomb corneal oedema caused by netarsudil [46,71,72]. However, this adverse effect was not found in any participant in the MERCURY-2 study [53].…”

Section: Safety Profile Of Netarsudilmentioning

confidence: 98%

ROCK Inhibitors in Corneal Diseases and Glaucoma—A Comprehensive Review of These Emerging Drugs

Pagano,

Lee,

Posarelli

et al. 2023

JCM

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Rho kinase (ROCK) inhibitors have gained significant attention as emerging novel treatment options in the field of ophthalmology in recent years. The evidence supporting their efficacy in glaucoma and corneal pathology includes both in vitro and clinical studies. Among the available options, ripasudil and netarsudil have emerged as the leading ROCK inhibitors, and some countries have approved these therapeutic options as treatments for glaucoma. Various dosing regimens have been studied, including monotherapy and combination therapy, especially for patients with secondary glaucoma who are already on multiple medications. Another rising application of ROCK inhibitors includes their use as an adjunct in surgical procedures such as Descemetorhexis Without Endothelial Keratoplasty (DWEK), Descemet Stripping Only (DSO) to accelerate visual recovery, glaucoma surgeries to reduce scarring process and allow better intraocular pressure (IOP) control, or after complicated anterior segment surgery to treat corneal oedema. This article provides a comprehensive overview of the existing literature in the field, offering recommendations for prescribing ROCK inhibitors and also discussing patient selection, drug efficacy, and possible adverse effects.

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