Rethinking the use of urine dipstick for early diagnosis of Type 2 diabetes mellitus

Jensen, Olaf Chresten; Flores, Agnes; Corman, Victoria; Canals, María Luisa; Lucas, David; Denisenko, Ilona; Lucero-Prisno, Don Eliseo-Iii; Secher, Anna; Andersen, Gregers; Jørgensen, Marit E.; Pujol, Helena; Cohen, Guido; Gyntelberg, Finn

doi:10.1016/j.diabres.2022.109222

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Urinary glucose has been widely used as a screening tool for diabetes since it is non-invasive, cheap and easy to perform. The problem with the low sensibility when using urine sticks for diagnosis of type 2 diabetes has existed for many years, but only recently been discussed in relation to maritime medical health examinations [12,13].…”

Section: Accurate Diagnosis Of Type 2 Diabetes In the Clinicmentioning

confidence: 99%

“…One important problem is that urinary glucose has been widely used as a screening tool for diabetes in the fitfor-duty examinations as described in APPENDIX F in the ILO international guidelines. However, due to its low sensitivity, it cannot be recommended as a valid screening test for diabetes [12][13][14]. In February 2021 the International Maritime Health Association (IMHA), Europeche, and the European Transport Workers Federation (ETF) prompted The Maritime Health Research and Education-Net (Mahre-Net) to address the problems.…”

Section: Introductionmentioning

confidence: 99%

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Screening for type 2 diabetes and hypertension in seafarers’ medical examinations

Jensen

Flores

Corman

et al. 2022

International Maritime Health

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Background:The aims of the study are: 1) to replace the urine glucose test for diabetes with more than 50% false negatives, with an accurate screening for type 2 diabetes and hypertension in the mandatory biannual fit-for-duty medical examinations of seafarers; 2) to produce data driven "Green Ship" health promotion in the ships. A new health promotion and disease prevention public health intervention programme integrated in the fit-for-duty medical examinations for seafarers is being developed. Materials and methods: The lack of an accurate diagnosis of type 2 diabetes is replaced by accurate HbA1c and/or fasting glucose tests and the test for hypertension in various disease stages is based on the International Associations' Guidelines. A "Green Ship" health promotion programme is proposed for all on board, not only for diseased crew members.Results: A protocol for an accurate biannual screening for diabetes and hypertension is presented. Educational programmes for medical doctors and seafarers on the management of hypertension and diabetes on board will be developed. Presuming that all crew members are potentially on their way to be pre-diseased or are diseased, the "Green Ship" health promotion programme is implemented for the whole crew. Conclusions: The International Labour Organization and the National Maritime Authorities are prompted to revise the International and the National Guidelines for Seafarers Medical Examinations, respectively. Concerted actions are requested to implement public health promotion projects in shipping. Maritime medical doctors are prompted to use health dialogues and to report the clinical data in the Excel file. Sustainability is obtained by complying with the Sustainable Development Goals (3, 4, 8, 10, and 17).

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Section: Accurate Diagnosis Of Type 2 Diabetes In the Clinicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening for type 2 diabetes and hypertension in seafarers’ medical examinations

Jensen

Flores

Corman

et al. 2022

International Maritime Health

Self Cite

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“…According to the latest data from the International Diabetes Federation (IDF), 382 million of the world's diabetic patients were expected to reach 592 million in 2035 [2]. At present, the prevalence rate of diabetes among adults in China is as high as 9.7 % and has become one of the fastest growing countries with high diabetic incidences in the world [3]. Since type 2 diabetes is an important cause of end-stage renal disease, the early diagnosis and treatment of type 2 diabetes complicated with renal damage is a hot topic both at home and abroad [4].…”

Section: Introductionmentioning

confidence: 99%

HINT2 may be One Clinical Significance Target for Patient with Diabetes Mellitus and Reduced ROS-Induced Oxidative Stress and Ferroptosis by MCU

Bai,

Lu,

Tan

et al. 2024

Horm Metab Res

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The World Health Organization (WHO) predicted that patients with diabetes around the world will increase to 600 million by 2040, of which about 1/3 will develop diabetic nephropathy (DN). Therefore, the present study aimed to uncover therapeutic effect of HINT2 and determined its possible mechanisms. Patients with diabetes mellitus and normal volunteers were enrolled at our hospital. Male C57BL/6 mice were fed with a high fat diet and injected intraperitoneally with STZ for once (100 mg/kg body weight). Mouse podocytes (MPC5) cells were induced with 20 mmol/l D-glucose. Inhibition of HINT2 mRNA expression levels in patients with DN was observed, compared with normal group. The serum of HINT2 mRNA expression was negative in correlation with blood sugar, tubulo-interstitial damage, glomerular damage score or urine protein level in patients with DN. HINT2 expression in kidney tissue of mice with DN were downregulated. HINT2 presented reduced DN and inflammation and ROS-induced oxidative stress in model of DN. HINT2 promoted ferroptosis in model of DN by mitochondrial membrane potential. HINT2 suppressed MCU expression in model of DN. HINT2 protein combined with MCU protein increased MCU protein ubiquitination. HINT2 triggers mitochondrial Ca2+ influx to increase ROS production level by MCU. Taken together, these findings demonstrated that HINT2 reduced ROS-induced Oxidative stress and ferroptosis by MCU, suggesting that HINT2 may be a feasible strategy to treat DN.

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“…The prediabetes remains unknown, and an important prevention potential is thus not utilised. Ignorance of the prevalence of prediabetes and T2DM is a serious obstacle to establishing relevant prevention [1][2][3].…”

mentioning

confidence: 99%

Call for the National Boards of Health and the Maritime Administrations to introduce valid screening for type 2 diabetes at the maritime medical examinations

Jensen

Corman

Canals

et al. 2023

IMH

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Rethinking the use of urine dipstick for early diagnosis of Type 2 diabetes mellitus

Cited by 3 publications

References 4 publications

Screening for type 2 diabetes and hypertension in seafarers’ medical examinations

Screening for type 2 diabetes and hypertension in seafarers’ medical examinations

HINT2 may be One Clinical Significance Target for Patient with Diabetes Mellitus and Reduced ROS-Induced Oxidative Stress and Ferroptosis by MCU

Call for the National Boards of Health and the Maritime Administrations to introduce valid screening for type 2 diabetes at the maritime medical examinations

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