Rethinking the risk for depression using the RDoC: A psychophysiological perspective

Abstract

Considering that the classical categorical approach to mental disorders does not allow a clear identification of at-risk conditions, the dimensional approach provided by the Research Domain Criteria (RDoC) is useful in the exploration of vulnerability to psychopathology. In the RDoC era, psychophysiological models have an important role in the reconceptualization of mental disorders. Indeed, progress in the study of depression vulnerability has increasingly been informed by psychophysiological models. By adopting an RDoC lens, this narrative review focuses on how psychophysiological models can be used to advance our knowledge of the pathophysiological mechanisms underlying depression vulnerability. Findings from psychophysiological research that explored multiple RDoC domains in populations at-risk for depression are reviewed and discussed. Future directions for the application of psychophysiological research in reaching a more complete understanding of depression vulnerability and, ultimately, improving clinical utility, are presented.

Latent profiles of regulatory flexibility in alcohol use disorder: Associations with delay discounting and symptoms of depression, anxiety, and stress

“…First, context sensitivity refers broadly to an individual's ability to consider contextual factors in their environment that may be important in choosing a regulatory strategy (i.e., attunement to situational demands; Bonanno et al., 2020; Bonanno & Burton, 2013; Chen & Bonanno, 2021). For example, individuals with depression have been shown to be insensitive to positive stimuli and show preference for negative cues (Dell'Acqua et al., 2023). Second, repertoire captures the array of emotion regulation/coping strategies an individual can implement (Bonanno & Burton, 2013; Burton & Bonanno, 2016; Chen & Bonanno, 2021; Cheng et al., 2014).…”