Rethinking of osteoporosis through a sex- and gender-informed approach in the COVID-19 era

Violi, Alessandra; Fortunato, V. Di; D’Amuri, Andrea; Zuliani, Giovanni; Basili, Stefania; Passaro, Angelina; Corica, Bernadette; Raparelli, Valeria

doi:10.23736/s2724-606x.21.04893-4

Cited by 5 publications

(4 citation statements)

References 140 publications

(145 reference statements)

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“…Our research mainly streams the second and third year of the COVID-19 pandemic, whereas medical realities continued to gain attention with the identification ofnew conditions or new approaches to diseases due to the infection itself or social and medical adjustments; overall, all medical and surgical fields have produced dynamic data [117][118][119][120]. Regarding the particular domain of bone changes (including during pregnancy and lactation), reductions in outdoor activities and sun exposure, deficiencies in applying pre-pandemic protocols of serial check-up, chronic stress and anxiety, as well as direct skeletal effects ongoing through coronavirus infection are parameters to be taken into consideration, as seen in the general population [121][122][123]. The infection has not been Our research mainly streams the second and third year of the COVID-19 pandemic, whereas medical realities continued to gain attention with the identification ofnew conditions or new approaches to diseases due to the infection itself or social and medical adjustments; overall, all medical and surgical fields have produced dynamic data [117][118][119][120].…”

Section: Gap 5: Is There a Place For Covid-19 Pandemic Considerations?mentioning

confidence: 99%

Bridging the Gap: Pregnancy—And Lactation—Associated Osteoporosis

Cârșote

Turturea²,

Valea

et al. 2023

Diagnostics

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Early diagnosis of pregnancy- and lactation-associated osteoporosis (PLO) is mandatory for a good outcome. Standard care is not a matter of conventional guidelines, rather it requires an individualized strategy while true overall incidence and pathogeny remain open issues. This is a narrative review based on full-length English articles, published between January 2021 and March 2023 and accessed via PubMed (no traumatic fractures or secondary osteoporosis are included). Our case-sample-based analysis included 836 females with PLO (the largest cohort based on published cases so far) through 12 studies and 24 single case reports. Except for one survey, these involved retrospective cohorts of small size (6–10 females/study) to medium size (23–47 women/study), and large cohorts with >50 subjects per study (a maximum of 379). Age of diagnosis: from 24 to 40 years for case reports (most subjects being over 30 and primigravida), while original studies indicated an average age between 31 and 34.18 years. Type of fractures underlined a most frequent vertebral phenotype (a mean of 2 to 5.8 vertebral fractures per patient) versus a most severe non-vertebral phenotype (hip and femoral neck fractures mostly requiring surgery). Potential contributors varied: smoking (1/3–1/2 of subjects), family history of osteoporosis (1/3), heparin and glucocorticoid use in pregnancy, low body mass index (majority of cases), hypovitaminosis D; and (with a low level of statistical significance) anti-psychotic medication, gestational diabetes, lupus, thrombophilia, anemia, in vitro fertilization (1/3 in one study), twin pregnancy, tocolysis with MgSO4, and postpartum thyroiditis. Most remarkably, up to 50% of PLO patients harbor mutations of LRP5, WNT1, and COL1A1/A2 (more damaged form with potential benefits from osteoanabolic drugs); gene testing might become the new norm in PLO. The low index of clinical suspicion should be supported by performing magnetic resonance imaging (gold standard in pregnancy) with DXA (in lactation). Low bone mineral density is expected (Z-score varying from −2.2 SD to −4 SD, unless normal which does not exclude PLO). Bone turnover markers might be useful in individuals with normal DXA, in pregnancy when DXA cannot be performed, and in following the response to anti-osteoporosis drugs. Alternatively, microarchitecture damage might be reflected by DXA-trabecular bone score and high-resolution peripheral quantitative computed tomography. Specific medical interventions are currently focused on teriparatide (TPT) use (3 studies; n = 99 females treated with TPT and an additional subgroup of 18 patients from the gene-analysis-based study, thus a total of 117 females) which seems to be the therapy of choice as reflected by these new data: 6–24 months, 20 µg/day, no sequential therapy needed; case selection based on high fracture risk is necessary). The first case using romosozumab was reported in 2022. PAO/LAO remains a challenging condition which is a battle for the wellbeing of two individuals, on one hand, considering maternal-fetal outcomes and taking care of the offspring, but it is a battle for a multidisciplinary team, on the other hand, since a standardized approach is lacking.

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Section: Gap 5: Is There a Place For Covid-19 Pandemic Considerations?mentioning

confidence: 99%

Bridging the Gap: Pregnancy—And Lactation—Associated Osteoporosis

Cârșote

Turturea²,

Valea

et al. 2023

Diagnostics

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“…The virus has become a very terrible terror for the world community because, in a short time, it has destroyed millions of people from various parts of the world, one of which is Indonesia (Matsumoto et al, 2021). Various efforts from each country have done their best for the pandemic (Violi et al, 2021). Some of the efforts are limiting social relations, limiting curfews, and using health protocols according to regulations.…”

Section: Findings the Development Of Sex Recession In The Contemporar...mentioning

confidence: 99%

Sexual Recession in Urban Muslim Societies: A Review of Maqashid Sharia and Its Implications

Sidqi,

Rasidin

2023

Akademika

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Sex recession is increasing from year to year in various countries. This phenomenon has the opportunity and potential to have a negative impact on the future of the younger generation and even the world’s population because it causes harm to many aspects, such as economic, political, socio-cultural, and religious aspects. This article aims to describe the law of sex recession from the viewpoint of Islamic marriage law and seeks to formulate the concept of policies to minimize sex recession in the world, especially in Indonesia, through maqashid sharia as the basis for its formation. The research method used is juridical-normative with a philosophical and conceptual approach. The theory used is maqashid sharia. The results of this research show that the sexual recession threatens the life of the nation and state. This is proven by the many impacts experienced by many countries, both from an economic, socio-cultural, political, and religious perspective. So, countries are flocking to make policies to reduce the sex recession. The authors offer policy concepts that can be considered, such as strengthening pre-marital education, increasing family resilience, efforts to minimize divorce, and building awareness in the Muslim community regarding marriage law, where these policies are conceptualized based on maqashid sharia. Policies that have clear direction can minimize the sexual recession effectively and efficiently in people’s lives.

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“…13 Various efforts to prevent the spread of the coronavirus have been carried out. 14 It includes the locking of regions and countries and the implementation of social distancing and physical distancing to break the chain of the spread of the coronavirus.…”

Section: Relations Of Sex In the Pandemic Eramentioning

confidence: 99%

Sex Recession Phenomenon from the Perspective Maqashid Sharia Based on Objectives Marriage Law in Indonesia

Pelu

Asfia²,

Tarantang

et al. 2022

Al-Istinbath : Jurnal Hukum Islam

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The sex recession is an implementation of worries about household responsibilities. Marriage, which is supposed to be a requirement for the legality of sexual relations, has experienced a shift. Marriage is no longer considered an appropriate institution with a modern lifestyle in several not Muslim-majority countries. The objective of this research is to offer solutions to the problem of a sexual recession that some of the world's most developed countries are currently facing. This type of research is empirical-normative research. The data is sourced from official news reports and reputable journals that reveal the sex recession in developed countries, such as the United States, England, Australia, and Asian countries such as Japan, South Korea, Singapore, and China. Research is being conducted using a phenomenological approach, a conceptual approach, and a philosophical approach. The result of this research are the epistemology of marriage in Islamic law is a solution to overcome the sex recession during the Covid-19 pandemic. In an ideal world, the phenomena of sex recession may be handled by adopting Islamic law's epistemology in terms of marriage. Even Indonesian marriage law can dispel sex recession by building awareness and understanding of the nature of marriage (maqasid marriage), which is systemically capable of maintaining and maintaining offspring, self-respect, and religion.

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Rethinking of osteoporosis through a sex- and gender-informed approach in the COVID-19 era

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Cited by 5 publications

References 140 publications

Bridging the Gap: Pregnancy—And Lactation—Associated Osteoporosis

Bridging the Gap: Pregnancy—And Lactation—Associated Osteoporosis

Sexual Recession in Urban Muslim Societies: A Review of Maqashid Sharia and Its Implications

Sex Recession Phenomenon from the Perspective Maqashid Sharia Based on Objectives Marriage Law in Indonesia

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