Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features

Drachman, Rebecca; Čolić, Lejla; Sankar, Anjali; Spencer, Linda; Goldman, Danielle; Villa, Luca M; Kim, Jihoon A.; Oquendo, María A.; Pittman, Brian; Blumberg, Hilary P.

doi:10.1016/j.jad.2022.02.047

Cited by 14 publications

(6 citation statements)

References 120 publications

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“…It will also be crucial to avoid misconceptions that can have negative consequences on these patients, including stigma. Future (longitudinal) studies might examine the role of comorbid personality traits, 107 impulsivity, manic and depressive symptoms, and substance use 81,108,97 to inform prevention and treatment strategies for maltreatment related aggression in individuals with AD.…”

Section: Discussionmentioning

confidence: 99%

“…(1) Global Social Functioning: overall functioning in any social domain or role 77 ; (2) Interpersonal Relations: level of engagement in social relationships (vs. isolation), family and community functioning, and social networks 79,80 ; (3) Aggressive Behaviour: physical and verbal aggression, hostility, violence, and criminal justice involvement 81 ; (4) Vocational Functioning: involvement in employment or education, 77 work engagement and skills 78 ; (5) Independent Living: level of independent functioning 77 or the ability to perform (without assistance from others) all or most of the daily functions typically required to be self‐sufficient, including those tasks essential to personal care and to maintaining a job and home or having a regular residence (vs. homelessness) 41 …”

Section: Methodsmentioning

confidence: 99%

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Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis

Fares-Otero

Prisco

Oliva

et al. 2023

Acta Psychiatr Scand

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Objective: Childhood maltreatment has been linked to impairments in social functioning and social cognition in adults with affective disorders. However, conclusions have been limited by inconsistent findings across different maltreatment subtypes and social domains. We conducted a systematic review and meta-analysis to quantify associations between childhood maltreatment (overall and subtypes -physical, emotional and/or sexual abuse, and/or physical and/or emotional neglect) and different domains of social functioning and social cognition in adults with affective disorders (bipolar disorder or major depressive disorder). We also examined effect moderators and mediators of these associations. Methods: A systematic search was performed on 12.12.2022 which identified 29 studies included in qualitative synthesis (n = 3022 individuals with affective disorders), of which 27 (n = 2957) were pooled in meta-analyses. Across studies, five social functioning and five social cognition domains were examined, of

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis

Fares-Otero

Prisco

Oliva

et al. 2023

Acta Psychiatr Scand

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“…3 The correlations were moderate with depressive and weak with (hypo)manic symptoms, probably because these items explore the regulation of negative emotions, as mentioned earlier. Risk behaviors are in fact a core symptom of mania 39 and, importantly, they are also related to aggressive behaviors, 86 mediated by common factors such as affective temperaments 87,88 or childhood maltreatment. 89,90 Indeed there is evidence that risk-taking was dependent on current mood status, as scores were highest in people with BD who were currently manic compared to those who were currently depressed or euthymic.…”

Section: Discussionmentioning

confidence: 99%

Correlation between emotion dysregulation and mood symptoms of bipolar disorder: A systematic review and meta‐analysis

Oliva,

De Prisco,

Fico

et al. 2023

Acta Psychiatr Scand

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BackgroundEmotion dysregulation (ED) is a transdiagnostic construct characterized by difficulties regulating intense emotions. People with bipolar disorder (BD) are more likely to show ED and use maladaptive emotion regulation strategies than adaptive ones. However, little is known about whether ED in BD is a trait or it is rather an epiphenomenon of mood symptoms.MethodsWe conducted a systematic review and meta‐analysis of the evidence across major literature databases reporting correlations between measures of emotion regulation (overall ED and different emotion regulation strategies) and measures of depressive and (hypo)manic symptoms in BD from inception until April 12th, 2022.ResultsFourteen studies involving 1371 individuals with BD were included in the qualitative synthesis, of which 11 reported quantitative information and were included in the meta‐analysis. ED and maladaptive strategies were significantly higher during periods with more severe mood symptoms, especially depressive ones, while adaptive strategies were lower.ConclusionED significantly correlates with BD symptomatology, and it mainly occurs during mood alterations. ED may be a target for specific psychotherapeutic and pharmacological treatments, according to precision psychiatry. However, further studies are needed, including patients with mood episodes and longitudinal design, to provide more robust evidence and explore the causal direction of the associations.

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“… 14 In recent years, several studies have proposed that substance use and childhood trauma also have significant effects on the risk of physical violence. 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

“…14 In recent years, several studies have proposed that substance use and childhood trauma also have significant effects on the risk of physical violence. 15,16 Previous studies on the risk of physical violence in BD-M relied on complex equipment and cumbersome and timeconsuming methods to analyze the markers. Moreover, despite the high specificity of several markers, the high cost of these techniques posed a significant impediment.…”

Section: Introductionmentioning

confidence: 99%

Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States

Li,

Gao,

Liu

et al. 2023

RMHP

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Purpose Identifying patients with bipolar disorder (BD) in manic states (BD-M) who are at a high risk of physical violence is a matter of clinical concern. This retrospective institution-based study aimed to identify simple, rapid, and inexpensive clinical markers of physical violence in patients with BD-M. Patients and Methods The anonymized sociodemographic variables (sex, age, years of education, marital status) and clinical ones (weight, height, body mass index, blood pressure, the score of BRMS, number of BD episodes, psychotic symptoms, history of violence, biochemical parameters, and blood routine parameters) of 316 BD-M participants were collected, and the risk of physical violence was identified using the Brøset Violence Checklist (BVC). Difference tests, correlation analyses, and multivariate linear regression analysis were performed to identify clinical markers for the risk of physical violence. Results The participants were categorized into groups at low (49, 15.51%), medium (129, 40.82%), and high (138, 43.67%) risk of physical violence. The number of BD episodes, serum uric acid (UA), free thyroxine (FT4) levels, history of violence, and monocyte-to-lymphocyte ratio (MLR) differed significantly between groups (all P <0.05). The number of BD episodes ( r =0.152), FT3 ( r =0.131) and FT4 ( r =0.132) levels, history of violence ( r =0.206), and MLR ( r =−0.132) were significantly correlated with the risk of physical violence (all P <0.05). The existence of history of violence, number of BD episodes, UA, FT4, and MLR were identified as clinical markers of the risk of physical violence in patients with BD-M (all P <0.05). Conclusion These identified markers are readily available at initial presentation and may help in the timely assessment and treatment of patients with BD-M.

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Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features

Cited by 14 publications

References 120 publications

Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis

Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis

Correlation between emotion dysregulation and mood symptoms of bipolar disorder: A systematic review and meta‐analysis

Clinical Markers of Physical Violence in Patients with Bipolar Disorder in Manic States

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