Retention of testicular integrity and testosterone levels upon ingestion of garlic cloves (Allium sativum) in the Sprague-Dawley rat

Memudu, Adejoke Elizabeth; Akinrinade, Ibukun; Ogundele, Olalekan Michael

doi:10.1016/s2221-1691(15)30351-8

Cited by 6 publications

(13 citation statements)

References 30 publications

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“…It is worthy of note that experimental chickens that were separated from the no-garlic/acetaminophen group (NG1) and placed on garlic-meal from one week paa (NG1g), had signi cantly lower (p<0.05) level of AST when compared with NG1 by 14-and 21-days paa. This signals the restorative ability of garlic on damaged liver cells as suggested by Kodera et al (2002), Bozin et al (2008) and Memudu et al (2015).…”

Section: Discussionmentioning

confidence: 73%

“…The lower level in the garlic group shows an enhanced cellular integrity of hepatocytes by garlic. An earlier study by Memudu et al(2015) showed increased proliferative activity with retention of testicular integrity and increased testosterone levels in Sprague-Dawley rat upon ingestion of garlic cloves. By 2 days paa, serum AST levels in the acetaminophen groups i.e.…”

Section: Discussionmentioning

confidence: 89%

“…Inspite of the induction of hepatotoxicity by acetaminophen, chickens in group G1 were able to mount a signi cantly higher level (p<0.05) of ND antibody response than the NG1 group, indicating the probable potential of garlic to preserve the immune function of the liver in the event of an hepatotoxic condition. Also, the higher level of antibody response in the NG1g group which was placed on garlic-meal after the induction of hepatotoxicity shows that garlic has the potential to enhance regeneration of liver tissue after an injury as suggested by Memudu et al (2015) with regards to testicullar cells.…”

Section: Discussionmentioning

confidence: 96%

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Garlic (Allium sativum Linn) Mitigates Experimentally induced Hepatotoxicity and Nephrotoxicity in Commercial Chickens

Oladele

Nottidge

Esan

et al. 2021

Preprint

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Intoxication as well as infectious and metabolic diseases resulting in liver and kidney damage are major causes of losses in poultry species. While there are no specific drugs for reversal of pathophysiology of the liver and kidney, certain herbs such as garlic have been shown to improve livability of livestock and poultry. Its probable potential at enhancing the functionality of these organs in the face of injuries/insults by intoxication was investigated. Chicken subgroup supplemented with 0.25% garlic-meal and administered 300mg/kg acetaminophen at 8week-old (G1; n=25) and subgroup without acetaminophen (G2; n=25), those not supplemented and without acetaminophen (NG2; n=25) and those not initially supplemented but administered acetaminophen and later supplemented (NG1g; n=20) had higher Newcastle disease vaccinal antibody titers (8.0±0.25, 7.5±0.24, 7.6±0.23, 8.14±0.31, respectively) in comparison with subgroup without supplementation and administered acetaminophen (NGI; n=25 - 7.13±0.38). Serum protein levels had a similar pattern. AST levels (U/L) were significantly higher (p<0.05) in acetaminophen subgroups G1 (79.4±5.79) and NG1 (83.7±7.5) than their respective controls G2 (75.1±7.85) and NG2 (65.2±6.84) with no corresponding increase in CK levels. At 2-, 7- and 14-days post-administration of acetaminophen (paa), creatinine (mg/dl) was significantly higher in G1 (1.44±0.01, 1.42±0.01, 1.44±0.02) and NG1 (1.47±0.01, 1.51±0.01, 1.47±0.01) than in G2 (1.16±0.05, 1.23±0.01, 1.26±0.06) and NG2 (1.31±0.06, 1.29±0.02, 1.31±0.05). A similar pattern was observed at 21 days paa. Clinical signs and pathological lesions associated with toxic dose of acetaminophen in liver and kidneys were reversed (NG1g). Thus, exhibiting the potential of garlic in protection against hepatorenal damage or injury.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 96%

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Garlic (Allium sativum Linn) Mitigates Experimentally induced Hepatotoxicity and Nephrotoxicity in Commercial Chickens

Oladele

Nottidge

Esan

et al. 2021

Preprint

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“…11 The nervous system and the brain function have been widely studied 12 as well as it possesses anticoagulant properties. 13 Some contrary reports are available where studies have shown a spermicidal effect of Allium sativum 14 on one hand, while others have reported its beneficial effects in the recovery of testicular functions. 15 Moreover, Allium sativum is a mood elevating and hepato-protective agent 16 which is also protective against protozoan infections [17][18][19][20] and reduces platelet aggregation.…”

mentioning

confidence: 99%

“…15 Moreover, Allium sativum is a mood elevating and hepato-protective agent 16 which is also protective against protozoan infections [17][18][19][20] and reduces platelet aggregation. [13][14][15][16][17][18][19][20][21] The active compounds of Allium sativum are volatile oil, sulphur, iodine, zinc, manganese, phosphorus, potassium, selenium, vitamin A, vitamins B 1 , B 2 and B 6 and vitamin C. In addition to various antioxidants, it also contains more than eighty sulfur-containing compounds. Out of these substances, allicin is the most known.…”

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confidence: 99%

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2017

IJPSR

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ABSTRACT:In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antimalarial drug, artesunate, which has been used as an alternative antimalarial drug against conventional drugs like chloroquine. Thirty six male mice were divided into six experimental groups. In the present study, Allium sativum was given at 100 mg/kg body weight with low dose (150 mg/kg body weight) and high dose (300 mg/kg body weight) of artesunate for 14 days and 21 days duration. Obtained results showed significant alterations in gravimetric indices as well as biochemical parameters. Moreover, administration of Allium sativum exhibited recovery and reestablishment of various altered indices in renal tissue as opposed to artesunate treated groups. This study obviously demonstrated that treatment with Allium sativum significantly attenuated the renal toxicity induced by artesunate in Mus musculus. Thus, it can be concluded from the observed results that Allium sativum could be used as a potent mitigating agent against antimalarial drug toxicity.

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Ethnobotanical knowledge of medicinal plants used in the treatment of male infertility in southern Benin

Agbodjento

Klotoé

Sacramento

et al. 2020

ADV TRADIT MED (ADTM)

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Infertility is a concern for couples, families and society. In almost half of the cases, it is due to male infertility. This infertility, in developing countries like Benin, often cured by the use of medicinal plants. This study aimed to enlist knowledge about medicinal plants used in the treatment of male infertility in southern Benin. An ethnomedicinal investigation has been conducted in southern Benin by questioning traditional healers and market herbalists using the method of semi-structured interview. Ethnopharmacological data has been analyzed by ethnobotanical indices such as informant consensus factor (ICF), frequency of citation for each plant species and contribution of each plant to drug recipes. 90 respondents including 36 market herbalists and 54 traditional healers participated in this study. Data collected allowed us to list 60 plant species belonging to 56 genera and 38 botanical families. Informants had a high degree of consensus (ICF = 0.58) on plants used for treatment of male infertility. The most plants cited by market herbalists were Garcinia kola (10.09%), Cissus populnea (10.09%), Carpolobia lutea (07.40%) and the parts of plants most used were roots and fruits. For traditional healers, Garcinia kola (10.15%), Cyperus esculentus (06.09%), Citrus aurantiifiola (06.09%) were the most plants cited and parts of plants the most used were leaves and roots. This study provided a list of medicinal plants used for the treatment of male infertility in southern Benin. Further pharmacological and toxicological studies will assess the therapeutic efficacy of these medicinal plants.

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Retention of testicular integrity and testosterone levels upon ingestion of garlic cloves (Allium sativum) in the Sprague-Dawley rat

Cited by 6 publications

References 30 publications

Garlic (Allium sativum Linn) Mitigates Experimentally induced Hepatotoxicity and Nephrotoxicity in Commercial Chickens

Garlic (Allium sativum Linn) Mitigates Experimentally induced Hepatotoxicity and Nephrotoxicity in Commercial Chickens

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Ethnobotanical knowledge of medicinal plants used in the treatment of male infertility in southern Benin

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