Retention of saffron bioactive components by spray drying encapsulation using maltodextrin, gum Arabic and gelatin as wall materials

Rajabi, Hamid; Ghorbani, Mohammad; Jafari, Seid Mahdi; Mahoonak, Alireza Sadeghi; Rajabzadeh, Ghadir

doi:10.1016/j.foodhyd.2015.05.033

Cited by 224 publications

(95 citation statements)

References 72 publications

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“…Numerous literatures regarding carotenoids are available which report; powder prepared via spray-drying of doublelayer W/O/W emulsion (Rodr ıduez- Huezo et al 2004) with highest microencapsulation efficiency and total carotenoids retention as well as microencapsulation of saffron extract as reported by Rajabi et al 2015, revealed, a 40% TS mixture consisting of gelatin (0.01), gum arabic (0.05), and maltodextrin (0.94) retained the highest amount of picrocrocin (90.06%), safranal (80.37%), and crocin (91.03%). Another study by Esfanjani et al 2015 reports; encapsulation of saffron extract nanoparticles (<100 nm) via spray-drying.…”

mentioning

confidence: 99%

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

Ahmad

Naqvi

Ashafaq

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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Antioxidants, with reported neuroprotective activity, encounter free radical induced neural damage leading to reduced risk of cerebral ischemia-reperfusion (IR) injury. Safranal, an antioxidant drug with potential role in the amelioration of cerebral ischemia, endures low solubility and poor absorption property thus resulting a low serum and tissue bioavailability. This research aims to prepare nanoemulsion with the concept; to increase the bioavailability in order to reduce oxidative stress-induced brain injury as well as to evaluate the brain-drug targeting following non-invasive nasal route administration in middle cerebral artery occlusion (MCAO) animal model. Titration method was used to prepare safranal mucoadhesive nanoemulsion (SMNE) followed by further characterization, i.e. entrapment efficiency, particles size, and zeta potential study. Optimized SMNE showed; mean globule size of 89.64 nm (±9.12), zeta potential -11.39 mV (±1.32), drug content 98.47% (±1.01), and viscosity of 124 cp (±14). Rats were subjected to 2 h of MCAO, successively followed by a 22 h reperfusion, after which the grip strength, locomotor activity, and biochemical studies, i.e. glutathione reductase (GR), glutathione peroxidase, lipid peroxidation, catalase, and superoxide dismutase were studied as assessment tool for effective treatment in brain. SMNE administered i.n. (intranasal) in MCAO induced cerebral ischemia rats exhibited significant improvement in neurobehavioral (locomotor and grip strength) and antioxidant activity as well as histopathological studies. The toxicity studies performed at the end revealed safe nature of developed SMNE.

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mentioning

confidence: 99%

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

Ahmad

Naqvi

Ashafaq

et al. 2016

Artificial Cells, Nanomedicine, and Biotechnology

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“…The technique of microencapsulation has been widely used to increase the efficacy of bioactive ingredients, such as fish oils (Pourashouri et al, 2014), polyphenols (Zheng et al, 2011), and natural colourants (Rajabi et al, 2015). An important step in microencapsulation process is the selection of a suitable wall material depending on properties of the bioactive ingredients, desired characteristics of the final products, and the microencapsulation methods (Jafari et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

On enhancing the solubility of curcumin by microencapsulation in whey protein isolate via spray drying

Liu

Chen

Zhang

et al. 2016

Journal of Food Engineering

147

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“…Table 3 demonstrates the concentration of methyl orange detected in these samples and their standard deviation. Quantification of methyl orange in counterfeit saffron samples was performed using calibration curves and confirmed by comparing absorption spectra of the samples with that of (Falcon and Gandara 2005;Rajabi et al 2015;Kobra et al 2015;Shukla and Iqbal 2015;Gonzalez et al 2003;Harp et al 2012;Sarfarazi et al 2015;Kiseleva et al 2003). Figure 3 shows the selected chromatogram of counterfeit saffron sample A, which was found positive for presence of methyl orange.…”

Section: Analysis Of Methyl Orange In Saffron Samplesmentioning

confidence: 99%

Detection of Methyl Orange in Saffron and Other Edibles Using Direct Injection Micellar Liquid Chromatography

Ashok

Agrawal²,

Esteve‐Romero

et al. 2016

Food Anal. Methods

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A simple, sensitive, rapid and eco friendly micellar liquid chromatographic method was developed for the detection of banned color methyl orange in counterfeit saffron and prepared foodstuffs. Methyl orange (p-[[p-(dimethylamino) phenyl] azo] benzenesulfonic acid sodium salt) is a hazardous dye used in titration and is known to be used as common adulterant in counterfeit saffron and cooked foodstuffs like Jalebi (Indian sweet), mango shake, Namkeen (salted snacks), tomato ketchup and ice candy etc., due to its pleasant orange color. In the present work, methyl orange was detected in various food samples using direct injection micellar liquid chromatography without any pretreatment step. A C18 column with an optimum micellar mobile phase containing 0.05-M sodium dodecyl sulfate (SDS), 2 % pentanol buffered to pH 7 was used. Detection was carried out at 458 nm. The retention time was 3.7 min without showing any matrix effect. Linearity (r > 0.9999), intraday and interday precision RSD (%) was less than 1.00 in micellar media. Limit of detection and quantification was found to be 0.05 mg/kg and 0.10 mg/ kg, respectively. Robustness study was also included as a part of method validation. The developed method proved to be reliable and sensitive for determination of methyl orange in real food samples.

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Retention of saffron bioactive components by spray drying encapsulation using maltodextrin, gum Arabic and gelatin as wall materials

Cited by 224 publications

References 72 publications

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

RETRACTED ARTICLE: The effect of safranal loaded mucoadhesive nanoemulsion on oxidative stress markers in cerebral ischemia

On enhancing the solubility of curcumin by microencapsulation in whey protein isolate via spray drying

Detection of Methyl Orange in Saffron and Other Edibles Using Direct Injection Micellar Liquid Chromatography

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