Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-Dihydroquinoxaline-2(1H)-Thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2′,3′-dideoxy-3′-thiacytidine (Lamivudine)

Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

“…28 HBY 097 potently inhibits both Lys103Asn (EC 50 = 3 nM) and Tyr181Cys (EC 50 = 2 nM) mutant RTs. 29 Structure (I) has an ATP molecule bound to the polymerase active site. The ATP binding mimics the metal coordination of an important catalytic reaction intermediate in DNA polymerization in which both the chelating metal ions have complete octahedral coordination.…”