Retention of immobile Se(0) in flow-through aquifer column systems during bioreduction and oxic-remobilization

Ho, Mallory S; Vettese, Gianni F.; Morris, Katherine; Lloyd, Jonathan R.; Boothman, Christopher; Bower, William R.; Shaw, Samuel; Law, Gareth T. W.

doi:10.1016/j.scitotenv.2022.155332

Cited by 3 publications

(4 citation statements)

References 68 publications

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“…These OS markers encompass molecules that undergo modifications as a consequence of ROS interactions, as well as components of the antioxidant system that undergo changes and modifications in response to stress conditions [187]. The selection of an OS marker relies on specific criteria, including its specificity, sensitivity to elevated ROS levels, temporal stability enabling sample collection and analysis, and result in reproducibility [188].…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

“…DNA, lipids (including phospholipids), proteins, and carbohydrates exemplify molecules susceptible to in vivo modifications induced by excessive ROS levels [188]. Hence, indirect assessment of ROS levels by examining oxidative damage to lipids, proteins, and nucleic acids within cellular systems presents a promising alternative for evaluating OS in clinical samples.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

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Oxidative Stress in Pregnancy

Grzeszczak,

Łanocha-Arendarczyk,

Malinowski

et al. 2023

Biomolecules

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Recent years have seen an increased interest in the role of oxidative stress (OS) in pregnancy. Pregnancy inherently heightens susceptibility to OS, a condition fueled by a systemic inflammatory response that culminates in an elevated presence of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the circulatory system. The amplified OS in pregnancy can trigger a series of detrimental outcomes such as underdevelopment, abnormal placental function, and a host of pregnancy complications, including pre-eclampsia, embryonic resorption, recurrent pregnancy loss, fetal developmental anomalies, intrauterine growth restriction, and, in extreme instances, fetal death. The body’s response to mitigate the uncontrolled increase in RNS/ROS levels requires trace elements that take part in non-enzymatic and enzymatic defense processes, namely, copper (Cu), zinc (Zn), manganese (Mn), and selenium (Se). Determination of ROS concentrations poses a challenge due to their short half-lives, prompting the use of marker proteins, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), and glutathione (GSH). These markers, indicative of oxidative stress intensity, can offer indirect assessments of pregnancy complications. Given the limitations of conducting experimental studies on pregnant women, animal models serve as valuable substitutes for in-depth research. This review of such models delves into the mechanism of OS in pregnancy and underscores the pivotal role of OS markers in their evaluation.

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Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Oxidative Stress in Pregnancy

Grzeszczak,

Łanocha-Arendarczyk,

Malinowski

et al. 2023

Biomolecules

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“…Subsurface sediments were sampled from a well characterised eld site in west Cumbria representative of the Sellaeld subsurface. 95,99 The sediments were sampled at approximately 10 cm depth into sealed, sterile HDPE bags, which were stored at 10 °C prior to use. For detailed analysis, see ESI Section SI1.…”

Section: Sediment Characterisationmentioning

confidence: 99%

“…In order to examine changes in the microbial community, DNA was extracted from the solids 99,108 in each treatment at 0 and 300 days of treatment, and then aer 100 days of re-oxidation with air and nitrate. Further details are provided in the ESI (Section 5 †).…”

Section: Microbial Analysismentioning

confidence: 99%

In situ (bio)remediation treatment options for U and Sr contaminated land: a comparison of radionuclide retention and remobilisation

Vettese,

Morris,

White-Pettigrew

et al. 2023

Environ. Sci.: Adv.

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Mechanisms Governing 90Sr Removal and Remobilisation in a VLLW Surface Disposal Concept

Vettese

Keto

et al. 2023

Minerals

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Flow-through columns were used to assess potential long-term trends in 90Sr biogeochemistry and transport in a Finnish near-surface very low-level waste (VLLW) repository concept. Experiments simulated the effects of water intrusion and flow through the repository barrier and backfill materials, examining impacts on 90Sr migration. Artificial rainwater containing 2.0 mg/L stable Sr (as a proxy for 90Sr) was pumped through column systems that had varying compositions from a matrix of rock flour (backfill material), bentonite (backfill/sealing material), and carbon steel (waste encapsulation material), for 295 days. Effluent geochemistry was monitored throughout. Sr retention behaviour in all column systems was broadly similar. Sr removal from influent rainwater was marked (~95% removed) at the beginning of the experiments, and this degree of removal was maintained for 20 days. Thereafter, Sr concentrations in the effluents began to rise, reaching ~2 mg/L by 295 days. Further, 56%–67% of added Sr was retained in the repository materials over the 295-day reaction period. Analysis of the effluents indicated that colloids did not form; as such, Sr output was likely to be aqueous Sr2+. Upon completion of the experiment, solid-associated Sr distribution and speciation in the columns were assessed through column sectioning and post-mortem analyses, which encompassed the following: total acid digests, sequential extractions, and XAS analysis. The total acid digests and sequential extractions showed that Sr was evenly distributed throughout the columns and that the majority (68%–87%) of solid-associated Sr was in the exchangeable fraction (MgCl2). This suggested that a major part of the solid-phase Sr was weakly bound to the column materials via outer-sphere sorption. Interestingly, a smaller amount of Sr (7%–23%) could only be extracted by aqua regia, suggesting that a proportion of Sr may bind more strongly to the barrier materials. XAS analysis of select samples confirmed that the dominant Sr phase was sorbed to the rock flour and bentonite, but not corroded carbon steel. Columns were also subject to remobilisation experiments using artificial rain- and seawater without added Sr. While rainwater remobilised Sr slowly, high-ionic strength seawater remobilised Sr at much higher rates in the systems containing bentonite. Interestingly, Sr was well retained in the rock flour-only system following rain and seawater intrusion. Overall, the results indicate that the column materials provide reactive surfaces for Sr removal should it be released from waste packages; however, the backfill and barrier materials have limited retention capacity, and the dominant sorption interaction is relatively weak. The safety case for the shallow disposal of radioactive waste should consider the possibility of seawater intrusion and that the bentonite-bound Sr was significantly more susceptible to remobilisation following seawater, despite retaining slightly more Sr during sorption experiments.

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Retention of immobile Se(0) in flow-through aquifer column systems during bioreduction and oxic-remobilization

Cited by 3 publications

References 68 publications

Oxidative Stress in Pregnancy

Oxidative Stress in Pregnancy

In situ (bio)remediation treatment options for U and Sr contaminated land: a comparison of radionuclide retention and remobilisation

Mechanisms Governing 90Sr Removal and Remobilisation in a VLLW Surface Disposal Concept

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