Retention of cadmium in organs of the rat after a single dose of labeled cadmium-3-phytate

Jackl, G. A.; Rambeck, Walter Albert; Kollmer, W. E.

doi:10.1007/bf02916564

Cited by 15 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, Cd absorption is enhanced when dietary concentrations of Ca, Fe and Zn are low (Flanagan et al 1978;Jacobs et al 1978;Kello et al 1979;Kostial et al 1980;Hoadley & Cousins, 1985;Schümann et al 1990;McKenna et al 1992;Wing et al 1992;Reeves & Chaney, 2001). In addition, increased intake of phytate and some dietary fibres appears to depress Cd uptake (Kiyozumi et al 1982;Jackl et al 1985;Lind et al 1998), but increased intake of protein appears to enhance Cd absorption and retention (Schäfer et al 1986;Kimura et al 1998). In our present study, dietary amounts of essential nutrients, except for Zn, were provided at or near recommended levels (National Research Council, 1995).…”

Section: Cadmium Absorption and Retentionmentioning

confidence: 78%

“…Others (Wing, 1993;Lind et al 1998) attributed decreased Cd absorption in animals fed wheat bran to the presence of phytate or fibre in the bran. In addition, Jackl et al (1985) reported that phytate markedly depressed Cd absorption in rats. Some dietary fibres have also been reported to depress Cd absorption (Kiyozumi et al 1982).…”

Section: Cadmium Absorption and Retentionmentioning

confidence: 99%

“…Many factors affect Cd bioavailability, including the nutritional status of the test subject, dietary composition and the form of Cd (Fox, 1988). Estimates of absorption or retention of dietary Cd by animals (Flanagan et al 1978;Jacobs et al 1978;Kostial et al 1978Kostial et al , 1980Welch et al 1978;Kello et al 1979;Welch & House, 1980;Kiyozumi et al 1982;Jackl et al 1985;Schäfer et al 1986;Fox, 1988;McKenna et al 1992;Reeves et al 1994;Reeves & Vanderpool, 1998;Reeves & Chaney, 2001) and by human subjects (Flanagan et al 1978;McLellan et al 1978;Strehlow & Barltrop, 1988;Berglund et al 1994;Crews et al 2000;) have been reported, but studies to assess the bioavailability of Cd in wheat are very few, and apparently limited to varieties of common wheat (Triticum aestivum L.).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Cadmium absorption and retention by rats fed durum wheat (Triticum turgidumL. var.durum) grain

et al. 2003

View full text Add to dashboard Cite

A whole-body radioassay procedure was used to assess the retention and apparent absorption by rats of Cd in kernels of durum wheat (Triticum turgidum L. var. durum ) harvested from plants grown hydroponically in 109 Cd-labelled nutrient solution. Wholegrain wheat, containing 5 mmol Cd (570 mg)/kg dry weight labelled intrinsically with 109 Cd, was incorporated into test meals fed to rats that had been maintained on diets containing marginally adequate, adequate or surplus levels of Zn (0·12 mmol (8 mg), 0·43 mmol (28 mg) or 1·55 mmol (101 mg) Zn/kg respectively), and either 0 or 50 g durum wheat/kg. Regardless of diet, all rats consumed about 99 % of the test meal offered. In rats fed diets without wheat, initial Cd absorption averaged 7·7, 4·6 and 2·4 % of the dose when the diet contained 0·12 mmol (8 mg), 0·43 mmol (28 mg) or 1·55 mmol (101 mg) Zn/kg diet respectively. In rats fed wheat-containing diets, initial Cd absorption averaged 3·8 and 2·6 % of the dose when dietary Zn concentration was 0·12 mmol (8 mg) and 0·43 mmol (28 mg)/kg diet respectively. The amount of Cd retained in the body at 15 d postprandial was ,2 % of the dose in all rats, and decreased as Zn in the diet increased. Even at 15 d postprandial, 32 to 44 % of the Cd retained in the body was still in the gastrointestinal tract. The results show that: (1) the bioavailability to rats of Cd in wholegrain durum wheat was depressed when wholegrain wheat was part of the regular diet; (2) increased intake of dietary Zn lowered Cd absorption and retention; (3) retention of Cd in the body at 15 d postprandial from diets containing adequate Zn was , 1·3 %. Cadmium retention: Cadmium absorption: Durum wheat: RatsThe amount of Cd in food and agricultural crops varies, and is influenced by several agronomic factors, particularly plant species and soil conditions (Wolnick et al. 1983;Mench, 1998;Welch & Norvell, 1999). In this respect, Cd concentrations in durum wheat (Triticum turgidum L. var. durum ) grain harvested in some areas of the northern Great Plains in the USA and adjoining regions of Canada may exceed 0·89 mmol (100 mg)/kg dry weight (Wolnick et al. 1983). The Cd content of food is important because excessive intake of Cd may cause several adverse health problems in human subjects (Goyer, 1995;Jarup et al. 1998;Satarug et al. 2000). To minimize dietary Cd intake, restrictions on the Cd content of unprocessed food products may be imposed. Thus, an upper limit of 0·89 mmol (100 mg) Cd/kg unprocessed durum wheat grain intended for export from the USA may be established (CODEX Alimentarius Commission, 1999). The proposed limit to the amount of Cd allowable in plant foods is based on the assumption that about 5 % Cd in plant foods is bioavailable (Andersen et al. 1992; World Health Organization, 1992). The study presented here was conducted to assess the absorption and retention by rats of Cd in wholegrain durum wheat. Bioavailability represents that portion of the element in the diet that is potentially absorbable from the lumen of the gastrointe...

show abstract

Section: Cadmium Absorption and Retentionmentioning

confidence: 78%

Section: Cadmium Absorption and Retentionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Cadmium absorption and retention by rats fed durum wheat (Triticum turgidumL. var.durum) grain

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Thus, a possible explanation for the reduced cadmium accumulation in the rats that were fed the calcium‐enriched diets may be a decrease in the cadmium binding activity due to a competitive interaction at the CaBP accompanied by a decrease in the mucosal cadmium uptake ( Breddermann and Wassermann, 1974). Furthermore, the effects might be due to the beneficial effect of PA concerning absorption and retention of cadmium ( Jackl et al, 1985) as well as antagonistic Ca—Cd‐interactions ( Rambeck, 1994; Rambeck and Guillot, 1996).…”

Section: Discussionmentioning

confidence: 99%

Effect of Calcium Supplements to a Maize—Soya Diet on the Bioavailability of Minerals and Trace Elements and the Accumulation of Heavy Metals in Growing Rats

Walter¹,

Rimbach²,

Most³

et al. 2000

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

Thirty-five (five groups with seven animals each) male albino rats (initial average weight = 44 g) were fed phytate-rich diets (analysed phytic acid concentration = 6.9 g/kg) based on maize and soy bean meal (5 g Ca, 3 g P, 1.2 g Mg, 23 mg Zn, 10 mg Pb, 5 mg Cd/kg diet). Experimental diets were supplemented with 0, 2, 4, 6 and 8 g calcium from CaCO3 per kg. The supplementation of increasing amounts of calcium resulted in a dose-dependent decrease in the apparent absorption of phosphorus. Furthermore, apparent zinc absorption and femur zinc concentration were moderately decreased due to the calcium supplementation. Kidney Cd concentration was significantly lower in rats that were fed the high calcium diets in comparison with the control animals. Femur lead concentration and hepatic delta-aminolevulinic acid dehydratase, which are known to be sensitive parameters of lead accumulation remained unchanged by the different dietary treatments. Magnesium absorption as well as liver and plasma zinc concentration and activity of plasma alkaline phosphatase were also unaffected. Although calcium supplementation may lead to a decrease in the accumulation of certain heavy metals such as cadmium, the carry-over of lead was not affected under the given experimental conditions. Furthermore, calcium-phytate-zinc interactions may adversely affect zinc bioavailability in growing rats.

show abstract

“…There were no significant difference (p≤0.05) in the concentrations of total protein, bilirubin , creatinine, inorganic phosphate and haemoglobin in both the test and control rabbits. Table 4 revealed that there was elevated total cyanide contents in the (Jack et al, 1985;McCane and Woddowson, 1953). Cyanogenic glycosides are precursors of hydrogen cyanide, a well known natural toxicant in foods.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the toxicity of cyanogens in a commonly consumed Nigeria legume pigeon pea (<i>Cajanus cajan</i>) seed and its biochemical effects in rabbits

Nwaogu¹,

Emejulu²

2011

International Journal of Biological and Chemical Sciences

View full text Add to dashboard Cite

The effect of a commonly consumed Nigeria legume pigeon pea (Cajanus cajan) seeds with high cyanogen concentration on some important biochemical parameters and haemoglobin concentration in new Zealand rabbits was investigated over a period of 72 hours. Quantitative analysis of the legume seed revealed that it has in mg/100g dry weight 39.3+1.30 cyanogenic glycosides, 11.57+1.20 phytate, 28.58+1.02 oxalate and 3.80+0.01 Tiu/100g dry weight typsin inhibitor respectively. Analysis of the serum and urine samples from test and control rabbits indicated that there was no significant difference (p≤ 0.05) in the concentrations of total protein, bilirubin, inorganic phosphate and creatinine. There was a slight decrease in the activities of alkaline phosphatase. However, the activities of serum transaminases: alanine amino transferase (ALT), aspartate amino transferase (AST) as well as cyanide concentration increased significantly (P≤±0.05). Cyanide concentration in the serum increased from 5 to 27 mg/l and that in the urine from 3.5 to 26mg/l in the rabbits fed with commercial feed when compared to those fed with Cajanus cajan formulated feed. The study revealed that consumption of Cajanus cajan seed made pulses occasionally would not result to cyanide toxicity.

show abstract

Retention of cadmium in organs of the rat after a single dose of labeled cadmium-3-phytate

Cited by 15 publications

References 9 publications

Cadmium absorption and retention by rats fed durum wheat (Triticum turgidumL. var.durum) grain

Cadmium absorption and retention by rats fed durum wheat (Triticum turgidumL. var.durum) grain

Effect of Calcium Supplements to a Maize—Soya Diet on the Bioavailability of Minerals and Trace Elements and the Accumulation of Heavy Metals in Growing Rats

Evaluation of the toxicity of cyanogens in a commonly consumed Nigeria legume pigeon pea (<i>Cajanus cajan</i>) seed and its biochemical effects in rabbits

Contact Info

Product

Resources

About