Retention indices of dimethylbenzamidines and benzylideneamines on a non-polar column

Rearrangement of 4-Imino-4H-3,1-benzoxazines to 4-Quinazolinones via Amidine Carboxamides

“…Dissolution of 10a in neat piperidine for 1 h or in 20% piperidine in EtOAc overnight, followed by concentration, affords 82% of amidine carboxamide 12 . The 1 H NMR spectrum shows a characteristic absorption at δ 6.55 which fits well with that reported for the parent amidine lacking the N -methylcarboxamide, and the absorption at δ 8.19 is shifted downfield from δ 8.01 in 10a . The configuration of the amidine carbon−nitrogen double bond was established by the strong NOE between the hydrogen at δ 6.55 and the methyl group at δ 1.92.…”

Ab Initio Study of Possible and Preferred Basic Site(s) in PolyfunctionalN,N1-Dimethyl-N-cyanoformamidine

“…Generally, the E isomer is most stable for the neutral, protonated, and complexed form. This configuration (E) has also been found as the preferred one for other neutral formamidines (FDM*R, R = alkyl, aryl, arylalkyl, heteroalkyl, heteroaryl) by different experimental methods (X-ray, 1 H and 13 C NMR, dipole moment measurements). ,,− ,− …”

“…This configuration (E) has also been found as the preferred one for other neutral formamidines (FDM*R, R ) alkyl, aryl, arylalkyl, heteroalkyl, heteroaryl) by different experimental methods (X-ray, 1 H and 13 C NMR, dipole moment measurements). 3,11,[13][14][15][46][47][48][49][50][51] Some selected geometrical parameters for structures 1-14 are summarized in Table 2. For each type of planar structures (see values of the N 1 -C 1 dN 2 -CN angle) of the neutral, protonated, and complexed forms, the C-N, CdN, and CtN bond lengths in the E isomer are slightly different from those in the Z isomer.…”

Retention indices and basicity of N1N1-dimethyl-N2-phenylformamidines. ortho-Substituent effect

“…For o-FDMP restricted rotation around the C-N single bond is not observed at room temperature in CDCl, as solvent, and the NMe, group gives one signal as observed for meta-and para-derivatives.' 93, 4 The identical, except for the o-hydroxy derivative (6), chemical shifts of protons in the NMe, group [G(NMe,) 3.0 & 0.1 for ortho-, meta-, and para-derivatives] indicates that the configuration at the C=N double bond of all the amidines studied is the same. Comparison of the n.m.r.…”