Retardation of Brain Myelination by Malnourishment and Feeding Low Protein Irradiated Diet in Rats

Habibulla, M; Krishnan, Hema S.

doi:10.1007/978-1-4684-2514-7_13

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…In post-natal rats, a low-protein diet can also result in a reduced number of glial cells, retarded brain myelination, and a paucity of hippocampal mossy fiber synapses (Robain et al, 1976; Habibulla and Krishman, 1978; Andrade et al, 1991). Protein-calorie malnutrition reversibly retarded nerve fiber growth in rat corticospinal pathways, optic nerves, spinal roots and peripheral nerves, the latter also showing differences in perineurial function (Sima et al, 1974; Sima and Sourander, 1976; Nordborg, 1977; Oldfors and Nordborg, 1977; Oldfors and Sourander, 1978; Bedi and Warren, 1983).…”

Section: 0 Nervous System Changes In Protein-energy Undernutritionmentioning

confidence: 99%

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Spencer

Palmer

2012

NeuroToxicology

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Section: 0 Nervous System Changes In Protein-energy Undernutritionmentioning

confidence: 99%

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Spencer

Palmer

2012

NeuroToxicology

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“…Although protein-deficient diets result in impaired brain development and activity [7], there is little information on how a protein-enriched diet may influence biochemical and physiological parameters that impact on CNS function. We have previously shown that dairy protein dietary supplementation, in the form of whey protein isolate (WPI) increased mitochondrial activity in mouse female liver [8].…”

Section: Introductionmentioning

confidence: 99%

Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain

Shertzer

Krishan

Genter

2013

Neuroscience Letters

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In humans and experimental animals, protein-enriched diets are beneficial for weight management, muscle development, managing early-stage insulin resistance and overall health. Previous studies have shown that in mice consuming a high fat diet, whey protein isolate (WPI) reduced hepatosteatosis and insulin resistance due in part to an increase in basal metabolic rate. In the current study, we examined the ability of WPI to increase energy metabolism in mouse brain. Female C57BL/6J mice were fed a normal AIN-93M diet for 12 weeks, with (WPI group) or without (Control group) 100 g WPI/L drinking water. In WPI mice compared to controls, the oxidative stress biomarkers malondialdehyde and 4-hydroxyalkenals were 40% lower in brain homogenates, and the production of hydrogen peroxide and superoxide were 25-35% less in brain mitochondria. Brain mitochondria from WPI mice remained coupled, and exhibited higher rates of respiration with proportionately greater levels of cytochromes a+a3 and c+c1. These results suggested that WPI treatment increased the number or improved the function of brain mitochondria. qRT-PCR revealed that the gene encoding a master regulator of mitochondrial activity and biogenesis, Pgc-1alpha (peroxisome proliferator-activated receptor-gamma coactivator-1alpha) was elevated 2.2-fold, as were the PGC-1alpha downstream genes, Tfam (mitochondrial transcription factor A), Gabpa/Nrf-2a (GA-binding protein alpha/nuclear respiratory factor-2a), and Cox-6a1 (cytochrome oxidase-6a1). Each of these genes had twice the levels of transcript in brain tissue from WPI mice, relative to controls. There was no change in the expression of the housekeeping gene B2mg (beta-2 microglobulin). We conclude that dietary whey protein decreases oxidative stress and increases mitochondrial activity in mouse brain. Dietary supplementation with WPI may be a useful clinical intervention to treat conditions associated with oxidative stress or diminished mitochondrial activity in the brain.

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Retardation of Brain Myelination by Malnourishment and Feeding Low Protein Irradiated Diet in Rats

Cited by 2 publications

References 13 publications

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Interrelationships of undernutrition and neurotoxicity: Food for thought and research attention

Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain

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