Retapamulin Ointment Twice Daily for 5 Days vs Oral Cephalexin Twice Daily for 10 Days for Empiric Treatment of Secondarily Infected Traumatic Lesions of the Skin

Abstract

Retapamulin offers a novel, effective, and convenient topical treatment for secondarily infected traumatic lesions.

Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus

“…Among the group of C14-sulfanyl-acetate derivatives, retapamulin is a topical antibiotic that was approved for clinical use in 2007. All strains of S. aureus and Streptococcus pyogenes were susceptible to retapamulin with low minimum inhibitory concentrations, <0.5 μg/mL (33,34). Other C14-sulfanyl-acetate derivatives, valnemulin and tiamulin, are approved for veterinary clinical use.…”

Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

“…† † Continuous efforts to develop pleuromutilin antibiotics yielded several semisynthetic derivatives, some of which with elevated activity over a broad spectrum of pathogens. The most advanced compound, retapamulin (SB-275833; SmithKline Beecham), has potent activity against Gram-positive pathogens (5-11) and a low propensity to select for resistance (12), has recently completed phase III clinical trials as a topical agent, showing that all strains of Staphylococcus aureus and Streptococcus pyogenes were susceptible to retapamulin with MICs Յ0.5 g/ml (13,14).…”

Studies on the Later Stage of the Biosynthesis of Pleuromutilin

“…9) The first pleuromutilin analogue, retapamulin, has recently been developed for human clinical use as a topical agent. 10,11) Hasler has proposed the later stage of pleuromutilin biosynthesis (Scheme 1) by a series of feeding experiments of 14 C-labeled precursors which were prepared from naturally obtained substances. 12) To engineer a biosynthetic pathway affording novel derivatives, elucidating the exact biosynthetic sequence is important.…”