Retained Negative Pressure Wound Therapy Foams as a Cause of Infection Persistence

Anagnostakos, Konstantinos; Thiery, Andreas; Sahan, Ismail

doi:10.1089/wound.2019.1088

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Available outpatient devices are smaller, more portable and available in single use delivery systems that employ mechanical or battery powered collection devices and dressings 54 . One important aspect is that retained foam or gauze after NPWT is a relatively common complication and is reportable as an adverse event 55 …”

Section: Dressing Managementmentioning

confidence: 99%

See 1 more Smart Citation

Chronic wounds: Treatment consensus

Eriksson

Liu

Schultz

et al. 2022

Wound Repair Regeneration

135

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The Wound Healing Foundation (WHF) recognised a need for an unbiased consensus on the best treatment of chronic wounds. A panel of 13 experts were invited to a virtual meeting which took place on 27 March 2021. The proceedings were organised in the sub‐sections diagnosis, debridement, infection control, dressings, grafting, pain management, oxygen treatment, outcomes and future needs. Eighty percent or better concurrence among the panellists was considered a consensus. A large number of critical questions were discussed and agreed upon. Important takeaways included that wound care needs to be simplified to a point that it can be delivered by the patient or the patient's family. Another one was that telemonitoring, which has proved very useful during the COVID‐19 pandemic, can help reduce the frequency of interventions by a visiting nurse or a wound care center. Defining patient expectations is critical to designing a successful treatment. Patient outcomes might include wound specific outcomes such as time to heal, wound size reduction, as well as improvement in quality of life. For those patients with expectations of healing, an aggressive approach to achieve that goal is recommended. When healing is not an expectation, such as in patients receiving palliative wound care, outcomes might include pain reduction, exudate management, odour management and/or other quality of life benefits to wound care.

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Section: Dressing Managementmentioning

confidence: 99%

“… 54 One important aspect is that retained foam or gauze after NPWT is a relatively common complication and is reportable as an adverse event. 55 …”

Section: Dressing Managementmentioning

confidence: 99%

Chronic wounds: Treatment consensus

Eriksson

Liu

Schultz

et al. 2022

Wound Repair Regeneration

135

View full text Add to dashboard Cite

show abstract

“…Dressings should be changed at least every 48 to 72 hours. In fact, a lower frequency easily results in foam saturation which decreases the effectiveness of treatment while increasing the risk of infection 28 . The canister must be changed when it is full or at least once a week 1, 26,27 .…”

Section: Discussion 1) How To Appropriately Use Npwt?mentioning

confidence: 99%

The application of negative pressure wound therapy in orthopedics: current concepts

et al. 2022

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We conducted a literature review to better understand the correct application and indications of negative pressure wound therapy (NPWT) in orthopedics and traumatology. A literature search was conducted on PubMed and all articles in English, Spanish, and Italian were included. Relevant articles, references, data, and relevant findings were identified, reviewed, extracted, and accepted by consensus of at least 66% of the researchers. Relevant articles were discussed by the research group. NPWT has several beneficial effects on the wound that contribute to the maintenance of a favorable biochemical and cellular environment, to the formation of granulation tissue and to faster healing. NWPT can be useful in the treatment of septic wounds after initial debridement surgery and removal of the septic foci, and in necrotizing fasciitis in the presence of gas gangrene, venous or pressure ulcers. NPWT can also be used "for prophylactic purposes" (incisional NPWT) in patients with risk factors for skin dehiscence and with a high risk of wound drainage in the post-operative period and after prosthetic surgery or internal fixation to protect the surgical scar. However, the available evidence is mostly unclear. The appropriate use of NPWT seems to reduce the number of dressing changes in complex wounds, reduce hospitalization times, and offer greater comfort to the patient; when applied on surgical incisions, it may reduce the risk of delayed healing and the risk of infections.

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“… 8 , 9 Recently, many adjunctive therapies have been developed including bioengineered skin grafts, hyperbaric oxygen therapy, negative pressure wound therapy, and biomaterial dressings. 10 However, bioengineered skin grafts have low bioavailability or immunological rejection, 11 and hyperbaric oxygen and negative pressure rely on special infrastructure, prone to barotrauma complications and increase bacterial infection rate, 12 , 13 resulting in limitations in clinical application. Biomaterials, such as collagen, chitosan, and hyaluronic acid (HA) gel, are low-priced and provide a moist environment, benefiting wound healing in DFU.…”

Section: Introductionmentioning

confidence: 99%

External Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Hyaluronic Acid Gel Repairs Foot Wounds of Types I and II Diabetic Rats Through Paracrine Action Mode

Chen,

Liu,

Zhang

et al. 2023

Stem Cells Translational Medicine

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Diabetic foot ulcer (DFU) is a main diabetic complication with unmet treatment needs. This study applied human umbilical cord-derived mesenchymal stem cells-hyaluronic acid (hucMSCs-HA) gel to treat DFU in a noninvasive external way and investigated its paracrine action and mechanism. In this study, after analyzing the physical and biological properties of HA gel, hucMSCs-HA gel was applied in 2 in vivo models (types I and II DFU), and a molecular mechanism was investigated. To evaluate the paracrine action of hucMSCs, hucMSCs-conditional medium (MSC-CM) was collected to treat 1 in vivo model (type I DFU) and 2 in vitro models (high glucose (HG)-injured human umbilical vein endothelial cells (HUVECs) and human skin fibroblasts (HSFs)). The results indicated that HA gel with a porous microstructure underwent over 90% degradation and swelled to the maximum value within 48 h. In vivo, hucMSCs-HA gel accelerated wound healing of DFU rats by improving re-epithelialization, collagen deposition, and angiogenesis, in which a paracrine action of hucMSCs was confirmed and the phosphorylation of p38, ERK1/2, JNK, and Akt was increased. In vitro, MSC-CM improved cell viability, wound healing, migration, tube formation, cell senescence, and abnormal expressions (TNF-α, IL-1β, IL-6, ET-1, p16 genes, and PCNA protein) of HUVECs, also improved cell viability, wound healing, antioxidant stress, and abnormal expressions (COL1, COL3, COL4, SOD1, SOD2 genes, and PCNA protein) of HSFs. Summarily, noninvasive external application of hucMSCs-HA gel shows great perspective against DFU and exerts wound healing effects through the MAPK and Akt pathways-mediated paracrine mechanism.

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Retained Negative Pressure Wound Therapy Foams as a Cause of Infection Persistence

Cited by 6 publications

References 62 publications

Chronic wounds: Treatment consensus

Chronic wounds: Treatment consensus

The application of negative pressure wound therapy in orthopedics: current concepts

External Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Hyaluronic Acid Gel Repairs Foot Wounds of Types I and II Diabetic Rats Through Paracrine Action Mode

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