“…Several endoscopists suggested clips would fall apart after a few weeks and be expelled from the body senselessly. 68 The typical postprocedural scar appears as a flat pale area, nonvascular or with neovascularization, and folds radiating outward. Tumor recurrence appears also as a nodule, usually unifocal and diminutive, with a characteristic surface pattern.…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, what happens to these clips once the defect heals is unknown. Several endoscopists suggested clips would fall apart after a few weeks and be expelled from the body senselessly 68. The typical postprocedural scar appears as a flat pale area, nonvascular or with neovascularization, and folds radiating outward.…”
Background and Aims:
To help prevent delayed adverse events after endoscopic surgery, endoscopists often place clips at the site. This meta-analysis aimed to assess the efficacy and safety of prophylactic clipping in the prevention of delayed bleeding and perforation after endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR).
Methods:
Multiple databases were searched from the inception dates to April 2021. And we included all relevant studies. Pooled odds ratio comparing the prophylactic clipped group versus nonprophylactic clipped group were calculated using the random effects model.
Results:
Twenty-seven articles fulfilled the inclusion criteria, with a total size of 8693 participants. There was statistically significant difference in prophylactic clipping versus no prophylactic clipping for delayed bleeding and perforation found in all studies (odds ratio: 0.35, 95% confidence interval: 0.25-0.49, P<0.01; odds ratio: 0.42, 95% confidence interval: 0.21-0.83, P<0.05; respectively). Besides, statistically significant difference was also found in subgroup analyses based on patients with lesions larger than 20 mm. Prophylactic clipping was more protective for duodenal delayed adverse events than colorectum. The use of clip closure was more protective to ESD-related delayed adverse events than EMR.
Conclusions:
Prophylactic clipping after ESD and EMR was beneficial in preventing delayed bleeding and perforation.
“…Several endoscopists suggested clips would fall apart after a few weeks and be expelled from the body senselessly. 68 The typical postprocedural scar appears as a flat pale area, nonvascular or with neovascularization, and folds radiating outward. Tumor recurrence appears also as a nodule, usually unifocal and diminutive, with a characteristic surface pattern.…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, what happens to these clips once the defect heals is unknown. Several endoscopists suggested clips would fall apart after a few weeks and be expelled from the body senselessly 68. The typical postprocedural scar appears as a flat pale area, nonvascular or with neovascularization, and folds radiating outward.…”
Background and Aims:
To help prevent delayed adverse events after endoscopic surgery, endoscopists often place clips at the site. This meta-analysis aimed to assess the efficacy and safety of prophylactic clipping in the prevention of delayed bleeding and perforation after endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR).
Methods:
Multiple databases were searched from the inception dates to April 2021. And we included all relevant studies. Pooled odds ratio comparing the prophylactic clipped group versus nonprophylactic clipped group were calculated using the random effects model.
Results:
Twenty-seven articles fulfilled the inclusion criteria, with a total size of 8693 participants. There was statistically significant difference in prophylactic clipping versus no prophylactic clipping for delayed bleeding and perforation found in all studies (odds ratio: 0.35, 95% confidence interval: 0.25-0.49, P<0.01; odds ratio: 0.42, 95% confidence interval: 0.21-0.83, P<0.05; respectively). Besides, statistically significant difference was also found in subgroup analyses based on patients with lesions larger than 20 mm. Prophylactic clipping was more protective for duodenal delayed adverse events than colorectum. The use of clip closure was more protective to ESD-related delayed adverse events than EMR.
Conclusions:
Prophylactic clipping after ESD and EMR was beneficial in preventing delayed bleeding and perforation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.