Resveratrol: un polifenol neuroprotector de la dieta mediterránea

López-Miranda,; Soto-Montenegro, María Luisa; Vera, González; Herradón, Esperanza; M, Desco; Ábalo, Ricardo del Corazón Grau

doi:10.33588/rn.5406.2011611

Cited by 12 publications

(4 citation statements)

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“…The ability of QCT to cross the BBB and the residence period & quantity of its metabolites in the brain are the most important factors in determining the dose of the QCT. Furthermore, the coadministration of alpha-tocopherol along with QCT was found to promote the crossing of BBB by QCT [ 2 , 14 - 18 ].…”

Section: Neuroprotective Effects Of Various Natural Productsmentioning

confidence: 99%

Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Wan

Mittal²,

Goyal

et al. 2023

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Phytochemicals or natural products have been studied extensively for their potential in the treatment of neurodegenerative diseases (NDs) like Parkinson’s disease, Alzheimer’s disease, etc. The neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In spite of impressive and thorough knowledge of neurodegenerative molecular pathways, little advancement has been found in the treatment of the same. Moreover, it was proved that natural products can be used efficiently in the treatment of NDs while certain issues regarding the patient's safety and clinical data are still existing. As ND is a bunch of diseases and it will start the myriad of pathological processes, active targeting of the molecular pathway behind ND will be the most efficient strategy to treat all ND-related diseases. The targeting pathway must prevent cell death and should restore the damaged neurons. In the treatment of ND and related diseases, natural products are playing the role of neuroprotective agents. This review will target the therapeutic potential of various phytochemicals which shows neuroprotective action.

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Section: Neuroprotective Effects Of Various Natural Productsmentioning

confidence: 99%

Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Wan

Mittal²,

Goyal

et al. 2023

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“…Both turmeric and resveratrol have antioxidant properties and could be potential neuroprotectors against neurodegenerative diseases where toxicity processes associated with free radicals are involved. In this sense, a neuroprotective effect of both of the molecules has been observed in Parkinson's disease (PD), AD, and brain trauma, all related to their antioxidant properties [11][12][13]. During SE seizures, free radicals are generated and contribute to glutamate-facilitated cytotoxicity, which induces apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant Effect of Turmeric and Resveratrol in Lithium/Pilocarpine-Induced Status Epilepticus in Wistar Rats

Zamora-Bello

Rivadeneyra-Domínguez²,

Rodríguez‐Landa³

2022

Molecules

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Epilepsy is a chronic neurological disorder that lacks a cure. The use of plant-derived antioxidant molecules such as those contained in turmeric powder and resveratrol may produce short-term anticonvulsant effects. A total of 42 three-month-old male Wistar rats were divided into six groups (n = 7 in each group): Vehicle (purified water), turmeric (150 and 300 mg/kg, respectively), and resveratrol (30 and 60 mg/kg, respectively), administered per os (p.o.) every 24 h for 35 days. Carbamazepine (300 mg/kg/5 days) was used as a pharmacological control for anticonvulsant activity. At the end of the treatment, status epilepticus was induced using the lithium–pilocarpine model [3 mEq/kg, intraperitoneally (i.p.) and 30 mg/kg subcutaneously (s.c.), respectively]. Seizures were evaluated using the Racine scale. The 300 mg/kg of turmeric and 60 mg/kg of resveratrol groups had an increased latency to the first generalized seizure. The groups treated with 150 and 300 mg/kg of turmeric and 60 mg/kg of resveratrol also had an increased latency to status epilepticus and a decreased number of generalized seizures compared to the vehicle group. The chronic administration of turmeric and resveratrol exerts anticonvulsant effects without producing kidney or liver damage. This suggests that both of these natural products of plant origin could work as adjuvants in the treatment of epilepsy.

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“…Ha demostrado tener propiedades farmacológicas, que incluyen capacidad antioxidante, actividad antiinflamatoria y anti-mutagénica, así como efectos anticancerígenos [3,14]. En sistema nervioso el resveratrol, tiene propiedades antioxidantes, antiinflamatorias y anti-apoptóticas, promoviendo así un efecto neuroprotector [2,3]. Sin embargo se metaboliza en poco tiempo lo cual disminuye su biodisponibilidad y su vida media plasmática es de 8 a 14 min y una degradación casi total a los 60 min [15], lo que se traduce en niveles bajos de resveratrol en el cerebro.…”

Section: Introductionunclassified

“…Resumen-Los traumas por lesión cerebral penetrante pueden variar desde un daño mínimo, generar defectos cognitivos y motores o incluso causar la muerte, lo que nos lleva a plantear un posible tratamiento. Entre estas alternativas encontramos al tamoxifeno y resveratrol que tienen propiedades antioxidantes, antiinflamatorias anti-apoptóticas y anti-mutagénicas promoviendo así un posible efecto neuroprotector [1][2][3]. Sin embargo, el resveratrol tiene baja estabilidad química y rápido metabolismo.…”

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Efecto del tratamiento con tamoxifeno y resveratrol en la locomoción de la rata después de daño cerebral penetrante en la corteza motora primaria

José,

Guillen,

García

et al. 2018

Memorias Del Congreso Nacional De Ingeniería Biomédica

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Los traumas por lesión cerebral penetrante pueden variar desde un daño mínimo, generar defectos cognitivos y motores o incluso causar la muerte, lo que nos lleva a plantear un posible tratamiento. Entre estas alternativas encontramos al tamoxifeno y resveratrol que tienen propiedades antioxidantes, antiinflamatorias anti-apoptóticas y anti-mutagénicas promoviendo así un posible efecto neuroprotector [1-3]. Sin embargo, el resveratrol tiene baja estabilidad química y rápido metabolismo. Esto hace necesario plantear una estrategia para estabilizar la molécula y facilitar su paso por la barrera hemato-encefálica, obteniendo efectos terapéuticos más efectivos. Planteamos una estrategia de tratamiento con tamoxifeno durante el periodo agudo del daño (0-2 post-lesión) y con resveratrol en la fase crónica (3-21 post-lesión), utilizando micropartículas lipídicas como vehículo de administración para el resveratrol y evaluando el efecto del tratamiento conjunto en la actividad locomotora después del daño en corteza motora mediante análisis de la locomoción a los 7, 14, 21 y 28 días post-lesión.

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Resveratrol: un polifenol neuroprotector de la dieta mediterránea

Cited by 12 publications

References 0 publications

Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Anticonvulsant Effect of Turmeric and Resveratrol in Lithium/Pilocarpine-Induced Status Epilepticus in Wistar Rats

Efecto del tratamiento con tamoxifeno y resveratrol en la locomoción de la rata después de daño cerebral penetrante en la corteza motora primaria

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