Resveratrol treatment has neuroprotective effects and prevents cognitive impairment after chronic cerebral hypoperfusion

Abstract

Results presented here show morphological and functional neuroprotective actions of RSV treatment for CCH, as well as support the inducing effects of RSV on the expression of NGF and its possible association to the neuroprotective action in this rodent model of vascular dementia.

Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model

“…25 In a previous study, it is shown that resveratrol treatment prevented both spatial working and reference memory impairments in CCH rats. 26 In this study, we extend the possible mechanism of resveratrol prevention on synaptic disorder in dendritic spines in CCH rats. We found that resveratrol could rescue the LTP inhibition and restore the impairments of dendritic spines in CCH rats.…”

Resveratrol, pterostilbene, and dementia

“…The administration of resveratrol for seven days after chronic cerebral hypoperfusion significantly decreased pyramidal cell death in the hippocampus and prevented impairment of spatial working and reference memory . Moreover, enhanced expression of nerve growth factor was found after 45 days in rats treated with resveratrol . The results of this study suggest a possible role of resveratrol in the expression of nerve growth factor and its neuroprotective effects in a model of vascular dementia.…”

“…The neuroprotective effects of resveratrol were examined in a rodent model of vascular dementia (chronic cerebral hypoperfusion after permanent two‐vessel occlusion) . The administration of resveratrol for seven days after chronic cerebral hypoperfusion significantly decreased pyramidal cell death in the hippocampus and prevented impairment of spatial working and reference memory . Moreover, enhanced expression of nerve growth factor was found after 45 days in rats treated with resveratrol .…”

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

“…A growing interest has emerged regarding the value of RES for its efficacy in metabolic regulation and neuroprotection with high safety margins [46,47]. Results of animal studies showed that with the dose of 10 or 20 mg/kg, RES could significantly improve the cognitive impairment induced by intracerebroventricular streptozotocin [48] and chronic cerebral hypoperfusion [49]. In terms of human beings, chronic treatment of RES with the dose ranging from 200 mg [20] to 1000 mg [50] daily was used in clinical trials and demonstrated well tolerated [51].…”