Resveratrol suppresses nuclear factor-κB in herpes simplex virus infected cells

Faith, Seth A.; Sweet, Thomas J.; Bailey, Erin; Booth, Tristan D.; Docherty, John J.

doi:10.1016/j.antiviral.2006.06.011

Cited by 114 publications

(83 citation statements)

References 38 publications

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“…Since resveratrol has potent antioxidative and anti-inflammatory properties, its antiviral effects have therefore been investigated. Recently, resveratrol was shown to be a potent antiviral molecule against various types of DNA and RNA viruses, including HSV-1 (herpes simplex virus 1), HSV-2, VZV (varicella-zoster virus), HCMV (human cytomegalovirus), and influenza A virus (11)(12)(13)(14)42). Here we demonstrated that resveratrol also possessed anti-RSV properties by using a CYP-induced immunocompromised BALB/c mouse model of RSV infection.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, Youn et al demonstrated previously that resveratrol suppressed NF-B activation and COX-2 expression by inhibiting TRIF signaling associated with the Toll-like receptor 3 (TLR3) and TLR4 MyD88-independent pathway by targeting TANK-binding kinase 1 and RIP1 in the TRIF complex (51). In recent years, several studies have demonstrated that resveratrol inhibited viral replication, e.g., influenza A virus, human cytomegalovirus, herpes simplex virus, and varicella-zoster virus, both in vitro and in vivo (11)(12)(13)(14)42).…”

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confidence: 99%

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Resveratrol-Mediated Gamma Interferon Reduction Prevents Airway Inflammation and Airway Hyperresponsiveness in Respiratory Syncytial Virus-Infected Immunocompromised Mice

Zang

Xie

Deng

et al. 2011

J Virol

121

111

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Resveratrol-Mediated Gamma Interferon Reduction Prevents Airway Inflammation and Airway Hyperresponsiveness in Respiratory Syncytial Virus-Infected Immunocompromised Mice

Zang

Xie

Deng

et al. 2011

J Virol

121

111

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“…16,17) Under normal circumstances, NF-κB is sequestered in the cytoplasm through binding with its inhibitory partner IκB (including IκBα). IκB prevents the translocation of NF-κB dimer (most commonly p50/p65) from the cytoplasm into the nucleus where it binds to DNA.…”

Section: )mentioning

confidence: 99%

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Shen

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

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Six stilbene derivatives isolated from Mulberry leaves including Kuwanon X, Mulberrofuran C, Mulberrofuran G, Moracin C, Moracin M 3′-O-b-glucopyranoside and Moracin M were found to have antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) at different potencies except for Mulberrofuran G. Kuwanon X exhibited the greatest activity against HSV-1 15577 and clinical strains and HSV-2 strain 333 with IC 50 values of 2.2, 1.5 and 2.5 µg/mL, respectively. Further study revealed that Kuwanon X did not inactivate cell-free HSV-1 particles, but inhibited cellular adsorption and penetration of HSV-1 viral particles. Following viral penetration, Kuwanon X reduced the expression of HSV-1 IE and L genes, and decreased the synthesis of HSV-1 DNA. Furthermore, it was demonstrated that Kuwanon X inhibited the HSV-1-induced nuclear factor (NF)-κB activation through blocking the nuclear translocation and DNA binding of NF-κB. These results suggest that Kuwanon X exerts anti-HSV activity through multiple modes and could be a potential candidate for the therapy of HSV infection.Key words anti-herpes simplex virus (HSV) activity; Kuwanon X; penetration; gene expression; nuclear factor (NF)-κB; Mulberry Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are prevalent pathogens worldwide. HSV-1 is the main cause of orofacial herpes, cephalitis, corneal blindness, and several disorders of the peripheral nervous system; HSV-2 is usually associated with recurrent genital herpes, meningoencephalitis in neonates and meningitis in adults. Both HSV-1 and HSV-2 can cause latent infections in the neurons system, and then cause lesions at or near the point of entry into the body when they are reactivated.1,2) Recently, it was reported that HSV infections can increase the transmission of human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1).3) During the productive infection, a successful HSV replication cycle is dependent on the completion of several steps, including α (immediate-early or IE), β (early or E), γ (late or L) genes and unpaired DNA replication based on sequential expression. The IE genes, such as UL54, encode transacting regulators of gene expression. The E genes, including UL52, are involved in viral DNA synthesis and nucleotide metabolism. The L genes, mainly encode structural proteins, e.g. ICP5 encoding the main capsid protein VP5. 4)The standard therapy for HSV infections are nucleoside analogues, such as acyclovir (ACV) and penciclovir. However, the emergence of HSV strains resistant to ACV remains an important clinical concern in immunocompromised individuals.5) Therefore, it is necessary to develop new antiherpetic agents with mechanisms of action different from that of nucleoside analogues.Mulberry (Morusalba L.) is widely cultivated in several Asian countries. Its leaves, fruits, twigs and root barks have long been used in Chinese medicine to reduce fever, maintain liver health, improve eyesight and lower blood pressure. Besides, Mulberry leaf is commonly...

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“…RES showed anti-inflammatory activities by the inhibition of 655 NF-κB activity via multiple mechanisms (Surh and Na, 2008). RES inhibited HSV replication 656 by suppressing NF-κB activity (Faith et al, 2006). NF-κB is a host nuclear transcription 657 factor, activated by multiple stimuli, including inflammatory cytokines, growth factors and 658 bacterial or viral infections (Santoro et al, 2003).…”

Section: Effect Of Res and Liposomal Res On Tnf-α And Il-1β Productiomentioning

confidence: 99%

Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections

Jøraholmen

Škalko‐Basnet

Acharya

et al. 2015

European Journal of Pharmaceutical Sciences

106

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Resveratrol (RES), chemically known as 3,5,4'-trihydroxy-transstilbene, is a promising multi-targeted anti-oxidative and antiinflammatory natural polyphenol. Preclinical studies showed its biological activities against the pathogens of sexually transmitted diseases causing vaginal inflammation and infections. Due to its low solubility and poor bioavailability, the optimal therapeutic uses are limited. Therefore, a clinically acceptable topical vaginal formulation of RES exhibiting optimal therapeutic effects is highly desirable. For this purpose, we prepared and optimized chitosan-coated liposomes with RES. The coated vesicles (mean diameter 200 nm) entrapped up to 77% of RES, a sufficient load to assure required therapeutic outcome. In vitro drug release study showed the ability of liposomes to provide sustained release of RES. In vitro anti-oxidative activities of RES, namely DPPH and ABTS*+ radicals scavenging assays, confirmed RES to be as potent as standard anti-oxidants, vitamins C and E. The anti-oxidative activities of RES and its corresponding liposomal formulation were also compared by measuring enhanced superoxide dismutase (SOD) activities in lipopolysaccharide (LPS)-induced J774A.1 cells. In vitro antiinflammatory activities were compared by measuring nitric oxide (NO), tumor necrosis factor (TNF)-α and interleukin (IL)-1β production in LPSinduced J774A.1 cells. Liposomal RES was found to exhibit stronger antioxidative and anti-inflammatory activities than RES solution. Resveratrol (RES), chemically known as 3,5,4'-trihydroxy-trans-stilbene, is a 18 promising multi-targeted anti-oxidative and anti-inflammatory natural polyphenol. Preclinical 19 studies showed its biological activities against the pathogens of sexually transmitted diseases 20 causing vaginal inflammation and infections. Due to its low solubility and poor 21 bioavailability, the optimal therapeutic uses are limited. Therefore, a clinically acceptable 22 topical vaginal formulation of RES exhibiting optimal therapeutic effects is highly desirable. 7Corrections were made accordingly as mentioned on page 8, lines 210-217. 8 9Please discuss the possibility for using other polymers instead of chitosan. 11Some discussion was added on page 18, lines 551-555 12 13Spelling error -page 7, section 2.7., should be "Characterization…" instead of

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Resveratrol suppresses nuclear factor-κB in herpes simplex virus infected cells

Cited by 114 publications

References 38 publications

Resveratrol-Mediated Gamma Interferon Reduction Prevents Airway Inflammation and Airway Hyperresponsiveness in Respiratory Syncytial Virus-Infected Immunocompromised Mice

Resveratrol-Mediated Gamma Interferon Reduction Prevents Airway Inflammation and Airway Hyperresponsiveness in Respiratory Syncytial Virus-Infected Immunocompromised Mice

Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties

Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections

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