Resveratrol suppresses calcium-mediated microglial activation and rescues hippocampal neurons of adult rats following acute bacterial meningitis

Sheu, Ji Nan; Liao, Wen Chieh; Wu, Un‐In; Shyu, Ling Yuh; Mai, Fu-Der; Chen, Li You; Chen, Mei Jung; Youn, Su Chung; Chang, Hui‐Ching

doi:10.1016/j.cimid.2012.11.002

Cited by 18 publications

(9 citation statements)

References 50 publications

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“…In adult rats, after intraventricular infection with K. pneumoniae, resveratrol reduced microglial activation, proinflammatory cytokine and malondialdehyde levels, and hippocampal neuronal injury [197].…”

Section: Radical Scavengingmentioning

confidence: 99%

Bacterial meningitis: an update of new treatment options

Nau

Djukic

Spreer

et al. 2015

Expert Review of Anti-infective Therapy

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The outcome of bacterial meningitis critically depends on the rapid initiation of bactericidal antibiotic therapy and adequate management of septic shock. In community-acquired meningitis, the choice of an optimum initial empirical antibiotic regimen depends on the regional resistance patterns. Pathogens resistant to antibacterials prevail in nosocomial bacterial meningitis. Dexamethasone is recommended as adjunctive therapy for community-acquired meningitis in developed countries. In comatose patients, aggressive measures to lower intracranial pressure <20 mmHg (in particular, external ventriculostomy, osmotherapy and temporary hyperventilation) were effective in a case-control study. Although many experimental approaches were protective in animal models, none of them has been proven effective in patients. Antibiotics, which are bactericidal but do not lyse bacteria, and inhibitors of matrix metalloproteinases or complement factor C5 appear the most promising therapeutic options. At present, vaccination is the most efficient method to reduce disease burden. Palmitoylethanolamide appears promising to enhance the resistance of the brain to infections.

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Section: Radical Scavengingmentioning

confidence: 99%

Bacterial meningitis: an update of new treatment options

Nau

Djukic

Spreer

et al. 2015

Expert Review of Anti-infective Therapy

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“…Central sensitization in inflammatory hyperalgesia is often associated with glial activation and secretion of cytokines in spinal cord (Sheu et al, ). In the present study, differential secretion of cytokines was observed in spinal cord at early (6 h) and late (48 h) phase.…”

Section: Resultsmentioning

confidence: 99%

“…The results suggest an inhibitory effect of resveratrol on glial activation in spinal cord at a late phase. Resveratrol is reported to have a neuro‐protective effect by inhibition of glial cell activation (Sheu et al, ; Zhang et al, ).…”

Section: Resultsmentioning

confidence: 99%

Anti-Nociceptive Effect of Resveratrol During Inflammatory Hyperalgesia via Differential Regulation of pro-Inflammatory Mediators

Singh

Vinayak

2016

Phytother. Res.

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Sensitization of nociceptive neurons by inflammatory mediators leads to hypersensitivity for normal painful stimuli which is termed hyperalgesia. Oxidative stress is an essential factor in pathological pain; therefore, antioxidants qualify as potential anti-hyperalgesic agents. The present study examines the efficacy of the natural antioxidant resveratrol in complete Freund's adjuvant (CFA) induced hyperalgesic rats. Thermal hyperalgesia was measured at different time points by paw withdrawal latency test and confirmed by c-Fos expression in spinal dorsal horn. The impact of resveratrol treatment on inflammatory mediators at peripheral (paw skin) and central (spinal cord) sites was determined during early (6 h) as well as late phase (48 h) of hyperalgesia. Intraplanter injection of CFA increased the level of cytokines IL-1β, TNF-α and IL-6 as well as inflammatory enzymes COX-2 and iNOS in paw skin in both phases. In case of spinal cord, the level of COX-2 was found to be elevated in both phases, whereas iNOS could not be detected. The cytokines were found to be elevated only in late phase in spinal cord. Administration of resveratrol (20 mg/kg) shifted the level of all inflammatory mediators towards normal, except cytokines in paw skin. The present study suggests that the anti-nociceptive effect of resveratrol is implicated at both peripheral and central sites in a tissue specific manner. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Once in the subarachnoid space, the relative lack of host defence mechanisms facilitates bacterial replication. Bacterial components trigger microglia and phagocytic cells to release pro-inflammatory mediators 27 such as TNF, IL-6, and IL-1B. These cause increased BBB permeability, leading to leucocyte adhesion to the BBB and invasion, thrombosis and further inflammation.…”

Section: Bacterial Colonisation and Invasionmentioning

confidence: 99%

Community-acquired acute bacterial meningitis in adults: a clinical update

Ellis

Luintel

Chandna

et al. 2019

British Medical Bulletin

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Background Acute bacterial meningitis (ABM) in adults is associated with a mortality that may exceed 30%. Immunization programs have reduced the global burden; in the UK, declining incidence but persistently high mortality and morbidity mean that clinicians must remain vigilant. Sources of data A systematic electronic literature search of PubMed was performed to identify all ABM literature published within the past 5 years. Areas of agreement and controversy Clinical features cannot reliably distinguish between ABM and other important infectious and non-infectious aetiologies. Prompt investigation and empirical treatment are imperative. Lumbar puncture (LP) and cerebrospinal fluid microscopy, biochemistry and culture remain the mainstay of diagnosis, but molecular techniques are increasingly useful. The 2016 UK joint specialist societies’ guideline provides expert recommendations for the management of ABM, yet published data suggest clinical care delivered in the UK is frequently not adherent. Anxiety regarding risk of cerebral herniation following LP, unnecessary neuroimaging, underutilization of molecular diagnostics and suboptimal uptake of adjunctive corticosteroids compromise management. Growing points There is increasing recognition that current antibiotic regimens and adjunctive therapies alone are insufficient to reduce the mortality and morbidity associated with ABM. Areas timely for developing research Research should be focused on optimization of vaccines (e.g. pneumococcal conjugate vaccines with extended serotype coverage), targeting groups at risk for disease and reservoirs for transmission; improving adherence to management guidelines; development of new faster, more accurate diagnostic platforms (e.g. novel point-of-care molecular diagnostics); and development of new adjunctive therapies (aimed at the host-inflammatory response and bacterial virulence factors).

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Resveratrol suppresses calcium-mediated microglial activation and rescues hippocampal neurons of adult rats following acute bacterial meningitis

Cited by 18 publications

References 50 publications

Bacterial meningitis: an update of new treatment options

Bacterial meningitis: an update of new treatment options

Anti-Nociceptive Effect of Resveratrol During Inflammatory Hyperalgesia via Differential Regulation of pro-Inflammatory Mediators

Community-acquired acute bacterial meningitis in adults: a clinical update

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