Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity

Hosseinimehr, Seyed Jalal; Hosseini, S. Amir

doi:10.1155/2014/839597

Cited by 19 publications

(13 citation statements)

References 33 publications

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“…The natural product resveratrol was found to exhibit a diverse range of biological activities in diseases associated with oxidative stress ( 1 ). As a polyphenolic natural product, resveratrol is automatically synthesized by plants in response to fungal attack or exposure to ultraviolet light ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells

et al. 2014

Molecular Medicine Reports

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The natural product resveratrol possesses diverse biological activities, including anti-inflammatory, anti-oxidant, anti-cancer and anti-aging effects in multiple organisms. The neuroprotective role of resveratrol has recently been reported in a cell model of amyloid (A)β(25–35)-induced neurotoxic injury using PC12 cells. However, the pathomechanism by which resveratrol inhibits neuronal apoptosis has remained to be elucidated. The present study therefore aimed to confirm the neuroprotective effects of resveratrol in an Aβ(25–35)-induced model of neurotoxicity in PC12 cells and elucidate the mechanisms underlying these effects. It was demonstrated that resveratrol exerted neuronal protection through inhibition of cell apoptosis, which was associated with an increased acetylation level of p53. In accordance with this effect, when the acetylation level of p53 was decreased by p53 acetylation inhibitor pifithrin-α, the protective effects of resveratrol were abrogated. In conclusion, it was revealed that resveratrol inhibited Aβ(25–35)-induced cell apoptosis via the acetylation of p53 in PC12 cells.

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Section: Introductionmentioning

confidence: 99%

Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells

et al. 2014

Molecular Medicine Reports

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“…The in vitro inhibitory effects of resveratrol on thyroid cancers have been documented. For instance, resveratrol enhances the rates of 131 I-induced cell death of thyroid cancer cell [ 45 ] and is able to suppress growth and to overcome retinoic acid resistance of human anaplastic thyroid cancer cells [ 13 ]. However, the in vivo impact(s)/influences of resveratrol in stepwise thyroid cancer formation is still lesser known.…”

Section: Discussionmentioning

confidence: 99%

Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis

Jia

Xue

et al. 2018

Nutrients

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Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50 male Sprague-Dawley rats were separated into four groups as Group-1 (5 rats); normally fed; Group-2 (15 rats); DEN/MNU/DHPN treatment only; Group-3 (15 rats) and -4 (15 rats); DEN/MNU/DHPN treatment; followed by resveratrol intragastric (IG) injection and intraperitoneal (IP) injection; respectively; in two-day intervals for 30 weeks. The results revealed that the average resveratrol concentration in thyroid tissues was 1.278 ± 0.419 nmol/g in IG group and 1.752 ± 0.398 nmol/g in IP group. The final body weights of Group-3 and Group-4 were lighter than that (p > 0.05) of Group-1; but heavier than Group-2 (p < 0.05). TC-related lesions (hyperplasia and adenomas) were found in 53.3% of Group-2; 33.3% Group-3 and 26.7% Group-4. Lower serum carcino-embryonic antigen (CEA) and thyroglobulin (Tg) levels; down-regulated expression of IL-6 and cyclooxygenase-2 (COX-2); reduction of NF-κB/p65 nuclear translocation; and elevated IkBα expression were found in the thyroid tissues of Group-3 and Group-4 in comparison with that of Group-2. These results demonstrate that IG and IP administered resveratrol efficiently reduces the frequency and severity of DEN/MNU/DHPN-caused TC-related lesions and would be of values in thyroid tumor prevention.

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“…More importantly, resveratrol sensitizes selectively thyroid cancer cells to 131-iodine toxicity, while it exhibited radioprotective effects on normal cells, thus for these beneficial actions, resveratrol might improve the treatment of patients with thyroid cancer during radioiodine therapy [63].…”

Section: Resveratrolmentioning

confidence: 99%

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

et al. 2020

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Nutraceuticals are defined as a food, or parts of a food, that provide medical or health benefits, including the prevention of different pathological conditions, and thyroid diseases, or the treatment of them. Nutraceuticals have a place in complementary medicines, being positioned in an area among food, food supplements, and pharmaceuticals. The market of certain nutraceuticals such as thyroid supplements has been growing in the last years. In addition, iodine is a fundamental micronutrient for thyroid function, but also other dietary components can have a key role in clinical thyroidology. Here, we have summarized the in vitro, and in vivo animal studies present in literature, focusing on the commonest nutraceuticals generally encountered in the clinical practice (such as carnitine, flavonoids, melatonin, omega-3, resveratrol, selenium, vitamins, zinc, and inositol), highlighting conflicting results. These experimental studies are expected to improve clinicians’ knowledge about the main supplements being used, in order to clarify the potential risks or side effects and support patients in their use.

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Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity

Cited by 19 publications

References 33 publications

Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells

Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells

Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis

Nutraceuticals in Thyroidology: A Review of in Vitro, and in Vivo Animal Studies

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