Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase

Scarlatti, Francesca; Sala, G; Ricci, Caterina; Maioli, Claudio; Milani, F; Minella, Marco; Botturi, M; Ghidoni, Riccardo

doi:10.1016/j.canlet.2007.01.014

Cited by 75 publications

(48 citation statements)

References 29 publications

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“…Resveratrol enhances ionizing radiation -induced cell death in DU145 cells, which are thought to be relatively radiation-resistant (Scarlatti et al, 2007), and as previously noted, enhances TRAIL-induced apoptosis in vivo . Radiosensitisation properties, at least in PC3 cells, also appear to belong to curcumin (Chendil et al, 2004;Li et al, 2007), and like resveratrol, curcumin also enhances TRAIL-induced apoptosis in prostate cancer cells (Deeb et al, 2005).…”

Section: Studies On the Combination Of Phytochemicals And Chemotherapysupporting

confidence: 73%

Dietary Manipulation for Therapeutic Effect in Prostate Cancer

Gano¹,

Scott²,

Bucci³

et al. 2012

Cancer Prevention - From Mechanisms to Translational Benefits

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Section: Studies On the Combination Of Phytochemicals And Chemotherapysupporting

confidence: 73%

Dietary Manipulation for Therapeutic Effect in Prostate Cancer

Gano¹,

Scott²,

Bucci³

et al. 2012

Cancer Prevention - From Mechanisms to Translational Benefits

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“…Resveratrol (9) induced synergistic enhancement of IR-induced cell death in DU 145 cells, which were shown to be resistant to IR treatment, by promoting production of de novo ceramide thereby leading to cell death (Scarlatti et al, 2007).…”

Section: Resveratrolmentioning

confidence: 99%

Phenylpropanoids in radioregulation: double edged sword

2011

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Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.

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“…Resveratrol has been reported to have cytotoxic effects on various types of cancers (1). On the other hand, resveratrol has been shown to be apoptotic, autophagocytic, a radiotherapy-sensitizer, a cell cycle arrester, an inhibitor of ROS generation in mitochondria, and a regulator of p53 in many cancers (4,5,7,(18)(19)(20). One of the most important properties of resveratrol is that it has selective toxic effects on cancer cells and far less effect on normal, healthy cells (21).…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol has drawn increasingly more attention recently since it has antiinflammatory, antimetastatic, cardioprotective, chemopreventive, cancer-preventive, apoptosis inducer, and radio-sensitizer potentials (3)(4)(5). Resveratrol affects the processes of tumor initiation, promotion, and progression (6).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Triggers Apoptosis Through Regulating Ceramide Metabolizing Genes in Human K562 Chronic Myeloid Leukemia Cells

Kartal

Saydam

Şahin

et al. 2011

Nutrition and Cancer

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Resveratrol, an important phytoalexin in many plants, has been reported to have cytotoxic effects on various types of cancer. Ceramide is a bioactive sphingolipid that regulates many signaling pathways, including cell growth and proliferation, senescence and quiescence, apoptosis, and cell cycle. Ceramides are generated by longevity assurance genes (LASS). Glucosylceramide synthase (GCS) and sphingosine kinase-1 (SK-1) enzymes can convert ceramides to antiapoptotic molecules, glucosylceramide, and sphingosine-1-phosphate, respectively. C8:ceramide, an important cell-permeable analogue of natural ceramides, increases intracellular ceramide levels significantly, while 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and SK-1 inhibitor increase accumulation of ceramides by inhibiting GCS and SK-1, respectively. Chronic myelogenous leukemia (CML) is a hematological disorder resulting from generation of BCR/ABL oncogene. In this study, we examined the roles of ceramide metabolizing genes in resveratrolinduced apoptosis in K562 CML cells. There were synergistic cytotoxic and apoptotic effects of resveratrol with coadministration of C8:ceramide, PDMP, and SK-1 inhibitor. Interestingly, there were also significant increases in expression levels of LASS genes and decreases in expression levels of GCS and SK-1 in K562 cells in response to resveratrol. Our data, in total, showed for the first time that resveratrol might kill CML cells through increasing intracellular generation and accumulation of apoptotic ceramides.

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Resveratrol sensitization of DU145 prostate cancer cells to ionizing radiation is associated to ceramide increase

Cited by 75 publications

References 29 publications

Dietary Manipulation for Therapeutic Effect in Prostate Cancer

Dietary Manipulation for Therapeutic Effect in Prostate Cancer

Phenylpropanoids in radioregulation: double edged sword

Resveratrol Triggers Apoptosis Through Regulating Ceramide Metabolizing Genes in Human K562 Chronic Myeloid Leukemia Cells

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