Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression

Abo-Zaid, Omayma Ar; Sallam, M.W.; El-Sonbaty, Sawsan M; Aziza, Samy; Emad, Basma; Ahmed, Esraa S. A.

doi:10.1007/s12011-021-03073-7

Cited by 56 publications

(26 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…735,736 It is a brain disorder associated with gradual weakening of neurocognitive functions, neuroinflammation, and impaired signaling pathways. 737 The SIRT proteins associated with AD mainly include SIRT1, although mitochondrial SIRTs represented by SIRT3 have also been the focus of research, as well as SIRT6 and SIRT2 that are located in the nucleus and cytosol, respectively. Amyloid beta (Aβ) is a normal and soluble product of neuronal metabolism, 738 and Aβ-mediated extracellular senile plaque is regarded as one of the major pathological lesions of AD.…”

Section: ) Other Intestinal Diseasesmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

223

View full text Add to dashboard Cite

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions. Moreover, identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules, which can modify SIRT activity. Furthermore, several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples, and supplementation of SIRT modulators might have diverse impact on physiological function in different participants. In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

show abstract

Section: ) Other Intestinal Diseasesmentioning

confidence: 99%

The sirtuin family in health and disease

Zhang

Chen

et al. 2022

Sig Transduct Target Ther

223

View full text Add to dashboard Cite

show abstract

“…Regarding nanoformulations of resveratrol, it was formerly reported that resveratrol selenium nanoparticles exhibited ameliorative effects against aluminium chloride-induced cerebral dysfunction and cognitive defects and the action was attributed to the antioxidant and antiinflammatory potentials (Abozaid et al 2022). Besides, nanostructured lipid carriers containing resveratrol ameliorated oxidative stress and cerebral inflammation following ischemic stroke in rats (Ashafaq et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats

2023

View full text Add to dashboard Cite

Malnutrition and low dietary protein intake could be risk factors for developing peripheral and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol proved to be effective against several hepatic and cerebral injuries. They were reported to be beneficial in lowering circulating ammonia levels, yet both are known for their low bioavailability. The use of pharmaceutical nano-formulations as delivery systems for these two nutraceuticals could solve the aforementioned problem. Hence, the present study aimed to investigate the valuable outcome of using a combination of curcumin and resveratrol in a nanoemulsion formulation, to counteract protein-deficient diet (PDD)-induced hyperammonemia and the consequent complications in male albino rats. Results revealed that using a nanoemulsion containing both curcumin and resveratrol at a dose of (5 + 5 mg/kg) effectively reduced hepatic and brain ammonia levels, serum ALT and AST levels, hepatic and brain nitric oxide levels, oxidative DNA damage as well as disrupted cellular energy performance. In addition, there was a substantial increase in brain levels of monoamines, and a decrease in glutamate content. Therefore, it can be concluded that the use of combined curcumin and resveratrol nanoemulsion is an effective means of ameliorating the hepatic and cerebral adverse effects resulting from PDD-induced hyperammonemia in rats.

show abstract

“…Resveratrol (DB02709), a polyphenolic phytoalexin, has been reported to affect several AD-related- and neuroprotective genes (Dennison et al, 2022 ). Resveratrol can improve AD-associated pathologies and produce therapeutic effects (Gomes et al, 2018 ; Rahman et al, 2020 ; Yan et al, 2020 ; Fang et al, 2021 ; Gu et al, 2021 ; Jang et al, 2021 ; Abozaid et al, 2022 ). Copper (DB09130) is a transition metal and a trace element in the body.…”

Section: Discussionmentioning

confidence: 99%

Hub Genes, Diagnostic Model, and Predicted Drugs Related to Iron Metabolism in Alzheimer's Disease

Lai

Liu

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Alzheimer's disease (AD), the most common neurodegenerative disease, remains unclear in terms of its underlying causative genes and effective therapeutic approaches. Meanwhile, abnormalities in iron metabolism have been demonstrated in patients and mouse models with AD. Therefore, this study sought to find hub genes based on iron metabolism that can influence the diagnosis and treatment of AD. First, gene expression profiles were downloaded from the GEO database, including non-demented (ND) controls and AD samples. Fourteen iron metabolism-related gene sets were downloaded from the MSigDB database, yielding 520 iron metabolism-related genes. The final nine hub genes associated with iron metabolism and AD were obtained by differential analysis and WGCNA in brain tissue samples from GSE132903. GO analysis revealed that these genes were mainly involved in two major biological processes, autophagy and iron metabolism. Through stepwise regression and logistic regression analyses, we selected four of these genes to construct a diagnostic model of AD. The model was validated in blood samples from GSE63061 and GSE85426, and the AUC values showed that the model had a relatively good diagnostic performance. In addition, the immune cell infiltration of the samples and the correlation of different immune factors with these hub genes were further explored. The results suggested that these genes may also play an important role in immunity to AD. Finally, eight drugs targeting these nine hub genes were retrieved from the DrugBank database, some of which were shown to be useful for the treatment of AD or other concomitant conditions, such as insomnia and agitation. In conclusion, this model is expected to guide the diagnosis of patients with AD by detecting the expression of several genes in the blood. These hub genes may also assist in understanding the development and drug treatment of AD.

show abstract

Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression

Cited by 56 publications

References 50 publications

The sirtuin family in health and disease

The sirtuin family in health and disease

Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats

Hub Genes, Diagnostic Model, and Predicted Drugs Related to Iron Metabolism in Alzheimer's Disease

Contact Info

Product

Resources

About