Resveratrol: review on therapeutic potential and recent advances in drug delivery

Pangeni, Rudra; Sahni, Jasjeet Kaur; Ali, Javed; Sharma, Shrestha; Baboota, Sanjula

doi:10.1517/17425247.2014.919253

Cited by 239 publications

(162 citation statements)

References 124 publications

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“…Despite there is extensive information on stilbene activities against plant fungal pathogens (see above) and Planta (2017) 246:597-623 609 human microbial pathogens (Pangeni et al 2014), there are scarce reports on stilbene activities and accumulation in response to phytopathogenic bacteria. Maddox et al (2010) reported that 12 phenolic compounds, including stilbenes, inhibited growth of a plant pathogenic bacterium, Xylella fastidiosa, isolated from grape and almond.…”

Section: Biotic and Abiotic Stresses As Regulators Of Stilbene Biosynmentioning

confidence: 99%

“…1), such as pterostilbene, oxyresveratrol, or viniferins, are the most famous stilbenes due to their diverse potent biological activities and medicinal properties and have been extensively studied (Kalantari and Das 2010;Pangeni et al 2014;Estrela et al 2013;Xu et al 2014;Wang and Yao 2015). Resveratrol has been shown to possess antioxidant, immunomodulatory, anti-inflammatory, and antiangiogenic effects and a wide range of health benefits, such as cancer chemoprevention or cardioprotection (Kalantari and Das 2010;Pangeni et al 2014;Weiskirchen and Weiskirchen 2016). A number of other stilbenoids ( Fig.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of stilbene biosynthesis in plants

Dubrovina

Kiselev

2017

Planta

134

126

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Main conclusion This review analyzes the advances in understanding the natural signaling pathways and environmental factors regulating stilbene biosynthesis. We also discuss the studies reporting on stilbene content and repertoire in plants.Stilbenes, including the most-studied stilbene resveratrol, are a family of phenolic plant secondary metabolites that have been the subject of intensive research due to their valuable pharmaceutical effects and contribution to plant disease resistance. Understanding the natural mechanisms regulating stilbene biosynthesis in plants could be useful for both the development of new plant protection strategies and for commercial stilbene production. In this review, we focus on the environmental factors and cell signaling pathways regulating stilbene biosynthesis in plants and make a comparison with the regulation of flavonoid biosynthesis. This review also analyzes the recent data on stilbene biosynthetic genes and summarizes the available studies reporting on both stilbene content and stilbene composition in different plant families.

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Section: Biotic and Abiotic Stresses As Regulators Of Stilbene Biosynmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regulation of stilbene biosynthesis in plants

Dubrovina

Kiselev

2017

Planta

134

126

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“…They aroused a huge interest in scientists after being identified in wine and linked to the "French paradox" and are mainly present in grape skin, but also in seeds, clusters, and stems (Katalinić et al, 2010). Thus, a big number of reviews confirming resveratrol's biological activities are present in the literature (Athar et al, 2007;Baxter, 2008;Smoliga et al, 2011;Pangeni et al, 2014). Due to their biological and organoleptic characteristics, anthocyanins and stilbenes play a key role in wine quality, and grape extracts are used as sources of natural compounds in the pharmaceutical, food and nutraceutical industries (Flamini et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Comparative Polyphenolic Content of Grape Pomace Flours from ‘Fetească neagră’ and ‘Italian Riesling’ Cultivars

Muncaciu

Marín

Pop

et al. 2017

Not Bot Horti Agrobo

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Grape pomace is a waste from wine industry which pollutes the environment. This by-product is considered a potential source of polyphenols, which were proven to be powerful antioxidants or natural coloring agents. The aim of this study was to quantify total polyphenols, total anthocyanins content and some stilbenes in grape pomace seed, skin and mixed flours from 'Fetească neagră' (cultivar for red wines) and 'Italian Riesling' (cultivar for white wines), grown in Miniș-Măderat vineyard, Romania. Flours were obtained by natural drying and ulterior grinding. One-way ANOVA and Tukey's post-hoc test were used.anthocyanins content was high in all the flours from 'Fetească neagră', with the highest concentration in skin flour (35.98 mg malvidin-3-O-glucoside/g dry weight). Stilbenes were also determined through HPLC methods. Cis-resveratrol was present in all forms of flour (0.90 to 10.14 μg/g dry weight), compared to its trans-isomer, which was not determined in 'Italian Riesling' seed and mixed flour. Trans-piceid was the most abundant stilbene and varied between 12.35 μg/g dry weight ('Italian Riesling' mixed flour) and 29.01 μg/g dry weight ('Fetească neagră' seed flour). The concentration of cis-piceid was similar among all forms of flour from 'Italian Riesling', while in 'Fetească neagră' seed flour (9.40 μg/g dry weight) it was present at a higher rate. Thus, results proved that 'Fetească neagră' flours are a better source of stilbenes than 'Italian Riesling' flours and seed flours from both varieties are richer in polyphenols than skin flours. Also, the concentration of anthocyanins in 'Fetească neagră' skin flour was high.

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“…Despite over 70% of resveratrol taking orally is absorbed across the gastrointestinal epithelium, the oral bioavailability is less than 1% because of rapid and extensive first pass metabolism mainly by Phase II metabolic reaction to sulfate and glucuronide conjugates [22,23]. It is not water soluble and also chemically unstable which requires development of custom designed formulation optimized specifically for resveratrol to enhance its oral delivery such as using micro-and nano-encapsulation with suitable carriers [22].…”

Section: Introductionmentioning

confidence: 99%

“…It is not water soluble and also chemically unstable which requires development of custom designed formulation optimized specifically for resveratrol to enhance its oral delivery such as using micro-and nano-encapsulation with suitable carriers [22]. It is also a substrate of efflux transporter proteins such as MRP2, MRP3, and ABCG2 which could further limit its gastrointestinal absorption and intracellular concentrations [24].…”

Section: Introductionmentioning

confidence: 99%