Resveratrol reserved hypoxia-ischemia induced childhood hippocampal dysfunction and neurogenesis via improving mitochondrial dynamics

Li, Hong; Xiao, Li; Liu, Zhizhen; Wu, Shirun; Guo, Jinwei; Shi, Ruiling; Sun, Yuqing; Wang, Yufei; Yin, Huaiqing

doi:10.1016/j.neures.2019.11.012

Cited by 16 publications

(17 citation statements)

References 25 publications

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“…Emerging evidence has shown that mitochondria are central to the hypoxic-ischemic injury response, and mitochondrial compromise is thought to underpin the secondary and tertiary stages of energy failure that culminates in perinatal brain injury, thereby making mitochondria a target for therapeutic intervention [ 14 – 17 ]. Indeed, studies have shown that hypoxic-ischemic injury impairs mitochondrial respiration in the adult rat brain [ 18 , 19 ], alters mitogenesis in the neonatal rat brain [ 20 , 21 ], and decreases mitochondrial respiration following a mild hypoxic insult in neonatal mice [ 22 ]. However, only a few studies have focused on mitochondrial function in the brain prior to birth [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain

Muccini

Tran

Hale

et al. 2022

Oxidative Medicine and Cellular Longevity

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Near-term acute hypoxia in utero can result in significant fetal brain injury, with some brain regions more vulnerable than others. As mitochondrial dysfunction is an underlying feature of the injury cascade following hypoxia, this study is aimed at characterizing mitochondrial function at a region-specific level in the near-term fetal brain after a period of acute hypoxia. We hypothesized that regional differences in mitochondrial function would be evident, and that prophylactic creatine treatment would mitigate mitochondrial dysfunction following hypoxia; thereby reducing fetal brain injury. Pregnant Border-Leicester/Merino ewes with singleton fetuses were surgically instrumented at 118 days of gestation (dGa; term is ~145 dGA). A continuous infusion of either creatine ( n = 15 ; 6 mg/kg/h) or isovolumetric saline ( n = 16 ; 1.5 ml/kg/h) was administered to the fetuses from 121 dGa. After 10 days of infusion, a subset of fetuses (8 saline-, 7 creatine-treated) were subjected to 10 minutes of umbilical cord occlusion (UCO) to induce a mild global fetal hypoxia. At 72 hours after UCO, the fetal brain was collected for high-resolution mitochondrial respirometry and molecular and histological analyses. The results show that the transient UCO-induced acute hypoxia impaired mitochondrial function in the hippocampus and the periventricular white matter and increased the incidence of cell death in the hippocampus. Creatine treatment did not rectify the changes in mitochondrial respiration associated with hypoxia, but there was a negative relationship between cell death and creatine content following treatment. Irrespective of UCO, creatine increased the proportion of cytochrome c bound to the inner mitochondrial membrane, upregulated the mRNA expression of the antiapoptotic gene Bcl2, and of PCG1-α, a driver of mitogenesis, in the hippocampus. We conclude that creatine treatment prior to brief, acute hypoxia does not fundamentally modify mitochondrial respiratory function, but may improve mitochondrial structural integrity and potentially increase mitogenesis and activity of antiapoptotic pathways.

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Section: Introductionmentioning

confidence: 99%

The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain

Muccini

Tran

Hale

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…On top of the aforementioned studies, H. Li et al (2020) discovered that resveratrol may promote hippocampal neurogenesis and prevent mitochondrial fragmentation induced by neonatal hypoxic ischemia in C57BL/6 mouse pups. By means of this mechanism, the compound was able to reverse the anxiolytic‐like behaviors that were evaluated in the elevated plus maze and open field tests.…”

Section: Stilbenes In Neuropsychiatric and Neurological Disordersmentioning

confidence: 99%

“…Li et al (2020) discovered that resveratrol may promote hippocampal neurogenesis and prevent mitochondrial fragmentation induced by neonatal hypoxic ischemia in C57BL/6 mouse pups. By means of this mechanism, the compound was able to reverse the anxiolytic-like behaviors that were evaluated in the elevated plus maze and open field tests.Considering the high number of people worldwide consuming water contaminated with arsenic as well as its neurotoxic properties, scientists decided to i.p., nevertheless, resveratrol was also administered p.o.…”

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confidence: 99%

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Socała,

Żmudzka,

Lustyk

et al. 2024

Phytotherapy Research

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Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi‐target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders. We describe and discuss the results of both in vitro and in vivo studies. The majority of studies concentrate on resveratrol, with limited findings exploring other stilbenes such as pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic resveratrol derivatives. Overall, although extensive preclinical studies show the potential benefits of stilbenes in various central nervous system disorders, clinical evidence on their therapeutic efficacy is largely missing.

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“…The above pathologic phenomenon was reversed by antidepressant treatment, suggesting that neurogenesis is associated with the altered course of depression ( Zeng et al, 2022 ). Neurogenesis, an important focus of hippocampal structural plasticity, produces full neural function that involves the proliferation and differentiation of neural stem cells ( Li et al, 2020 ). Berberine was able to protect C17.2 neural stem cells from the 2,2′-azobis(2-amidinopropane)dihydrochloride-induced oxidative damage; to be more specific, it lowered the cellular reactive oxygen species level in C17.2 cells via the nuclear factor erythroid 2-related factor 1/2 (NRF1/2)-NAD(P)H quinone dehydrogenase 1–heme oxygenase 1 pathway.…”

Section: Introductionmentioning

confidence: 99%

Current Evidence and Future Directions of Berberine Intervention in Depression

Zhu

Sun

et al. 2022

Front. Pharmacol.

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A major type of serious mood disorder, depression is currently a widespread and easily overlooked psychological illness. With the low side effects of natural products in the treatment of diseases becoming the pursuit of new antidepressants, natural Chinese medicine products have been paid more and more attention for their unique efficacy in improving depression. In a view from the current study, the positive antidepressant effects of berberine are encouraging. There is a lot of work that needs to be done to accurately elucidate the efficacy and mechanism of berberine in depression. In this review, the relevant literature reports on the treatment of depression and anxiety by berberine are updated, and the potential pharmacological mechanism of berberine in relieving depression has also been discussed.

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Resveratrol reserved hypoxia-ischemia induced childhood hippocampal dysfunction and neurogenesis via improving mitochondrial dynamics

Cited by 16 publications

References 25 publications

The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain

The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Current Evidence and Future Directions of Berberine Intervention in Depression

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