Resveratrol regulates the expression of LXR-α in human macrophages

Sevov, Marie; Elfineh, Lioudmila; Cavelier, Lucia

doi:10.1016/j.bbrc.2006.07.155

Cited by 81 publications

(50 citation statements)

References 59 publications

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“…At the dose used (10 mol/L), TO901317 had no effect on cell viability or cellular protein (␤-actin) levels. Resveratrol has also been shown to be an LXR agonist 34 …”

Section: Org)mentioning

confidence: 99%

“…This is consistent to the work of Huuskonen et al, which showed the same LXR agonist to inhibit the synthesis and secretion of apoA-I, through a transcriptional regulation involving hepatic nuclear factor-4. 8 Resveratrol is different class of compound that has LXR agonist activity and raises ABCA1 levels 34 and also has inhibitory effects on LA-phospholipid-induced apoA-I secretion. However, resveratrol is also a potent F 1 -ATPase inhibitor 57 and its effects on apoA-I secretion were similar to that seen with oligomycin.…”

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confidence: 99%

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An Induction in Hepatic HDL Secretion Associated with Reduced ATPase Expression

Pandey

Renwick

Rabaa

et al. 2009

The American Journal of Pathology

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“…At the dose used (10 mol/L), TO901317 had no effect on cell viability or cellular protein (␤-actin) levels. Resveratrol has also been shown to be an LXR agonist 34 …”

Section: Org)mentioning

confidence: 99%

mentioning

confidence: 99%

An Induction in Hepatic HDL Secretion Associated with Reduced ATPase Expression

Pandey

Renwick

Rabaa

et al. 2009

The American Journal of Pathology

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“…14 Resveratrol regulates the expression of LXRalpha in human macrophages. 15 Chlorogenic acid is rapidly metabolized to caffeic acid or ferulic acids after coffee consumption in rats and humans. 16,17 Although caffeic acids inhibit the development of atherosclerosis in mice by attenuating inflammation, 18 it remains unclear whether the phenolic acids of coffee affect cholesterol efflux from macrophages.…”

mentioning

confidence: 99%

Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages

Uto‐Kondo

Ayaori

Ogura

et al. 2010

Circulation Research

102

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Rationale: Association of habitual coffee consumption with coronary heart disease morbidity and mortality has not been established. We hypothesized that coffee may enhance reverse cholesterol transport (RCT) as the antiatherogenic properties of high-density lipoprotein (HDL). Objective: This study was to investigate whether the phenolic acids of coffee and coffee regulates RCT from macrophages in vitro, ex vivo and in vivo. Methods and Results: Caffeic acid and ferulic acid, the major phenolic acids of coffee, enhanced cholesterol efflux from THP-1 macrophages mediated by HDL, but not apoA-I. Furthermore, these phenolic acids increased both the mRNA and protein levels of ATP-binding cassette transporter (ABC)G1 and scavenger receptor class B type I (SR-BI), but not ABCA1. Eight healthy volunteers were recruited for the ex vivo study, and blood samples were taken before and 30 minutes after consumption of coffee or water in a crossover study. The mRNA as well as protein levels of ABCG1, SR-BI, and cholesterol efflux by HDL were increased in the macrophages differentiated under autologous sera obtained after coffee consumption compared to baseline sera. Finally, effects of coffee and phenolic acid on in vivo RCT were assessed by intraperitoneally injecting Key Words: HDL cholesterol Ⅲ efflux Ⅲ coffee Ⅲ phenolic acid H igh-density lipoproteins (HDLs) have been shown to be inversely associated with the risk of atherosclerotic cardiovascular disease (CVD) 1,2 and thus considered as antiatherogenic lipoproteins. Among antiatherogenic mechanisms including beneficial effects on inflammation, impaired endothelial function or hypercoagulation, HDL exerts the antiatherogenic property primarily by facilitating the efflux of cholesterol from peripheral tissues and transport it back to the liver in a process called reverse cholesterol transport (RCT). A major breakthrough in the understanding of the mechanism of RCT came with the discovery of the ATP binding cassette transporter (ABC)A1. Lipid-poor apolipoprotein (apo)A-I contributes to ABCA1-mediated cholesterol efflux from cells, but not HDL. 3,4 Another ABC transporter, ABCG1, is also involved in the cholesterol efflux from macrophages mediated by HDL, but not apoA-I. 4,5 Scavenger receptor class B type I (SR-BI) is also known to promote HDL-mediated cellular cholesterol efflux. 6 Furthermore, the pivotal roles of these molecules on intracellular cholesterol homeostasis, associated with reverse cholesterol transport, have also been confirmed by animal studies where deletions of ABCA1, 7 ABCG1, 8 and SR-BI 9 in macrophages accelerated the development of atherosclerosis.Coffee is among the most widely consumed beverages worldwide. The relationship between coffee consumption and the incidence of CVD has been studied extensively. 10 -12 In addition, a recent study reported that regular coffee consumption might be associated with a decreased cardiovascular mortality rate. 13 Coffee beans are known to be abundant in antioxidant phenolic acids, chlorogenic acid. Indeed, Xia M et...

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“…Another consideration that we have to take into account is that other antioxidants compounds of red wine could give more stability to the resveratrol than the pure resveratrol 56,57 . This could be the reason why resveratrol at µM concentration is currently used in the literature [58][59][60][61] . There are few reports of the effects of red vs white wine on plasma SHBG levels: a 5% reduction in plasma SHBG levels was observed in premenopausal drinking red wine vs white wine, but the red wine used in that study contained only 0.9 mg/L of resveratrol 62 .…”

Section: Discussionmentioning

confidence: 99%

Resveratrol increases hepatic SHBG expression through human constitutive androstane receptor: a new Contribution to the French Paradox

Sáez-López¹,

Brianso-Llort²,

Torres-Torrenteras³

et al. 2017

EJEA

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Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR), a drug/xenobiotic detoxification gene regulator, to increase hepatic SHBG production. Chromatin immunoprecipitation and luciferase reporter gene assays show that human CAR binds to a typical direct repeat 1 nuclear hormone receptor-binding element in the human SHBG proximal promoter. Resveratrol also increased hepatic SHBG production in humanized SHBG/CAR transgenic mice. Moreover, SHBG expression correlated significantly with CAR mRNA levels in human liver biopsies. We conclude that the beneficial effects of red wine on the metabolic syndrome and it associated co-morbidities, including cardiovascular disease and type 2 diabetes, may be mediated in part by resveratrol acting via CAR to increase plasma SHBG levels.Sex hormone-binding globulin (SHBG) is produced and secreted by the human liver into the blood, where it binds androgens and estrogens with high affinity, regulating their bioavailability 1 . Low plasma SHBG levels are associated with obesity and the metabolic syndrome predicting risk for type 2 diabetes 2-5 and cardiovascular disease 4,6,7 . Studies of human SHBG regulation have revealed cis-acting elements in the human SHBG proximal promoter that interact with members of the nuclear hormone receptor (NHR) family, including HNF4α and COUP-TF that compete for an imperfect NHR DR-1 (direct repeat-1) element located about 20 bp upstream of the transcription start site, and act as the main stimulators and repressors of SHBG expression in liver cells, respectively 8 . In addition, PPARγ interacts with a consensus DR-1 element located about 50 bp further upstream, which also binds HNF4α and COUP-TF 8 , and PPARγ binding at this position represses SHBG transcription 9 . Olive oil and red wine are important components of the Mediterranean diet 10 that are associated with a decreased risk of cardiovascular disease [11][12][13][14] . We have shown that olive oil consumption is associated with elevated serum SHBG levels and that PPARγ downregulation induced by oleoyl-CoA is an underlying mediator of this effect 15 . Numerous epidemiological studies indicate that cardiovascular risk is decreased by moderate wine consumption, providing an explanation for the "French Paradox" [16][17][18][19] . The beneficial cardiovascular effects of wine consumption have been attributed to components other than alcohol [20][21][22] , which are generally referred to as congeners of alcoholic beverages. These include the polyphenols, and red wine contains between 5 and 20-fold higher concentrations of polyphenols than does white wine 23,24 . Among these polyphenols, resveratrol

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Resveratrol regulates the expression of LXR-α in human macrophages

Cited by 81 publications

References 59 publications

An Induction in Hepatic HDL Secretion Associated with Reduced ATPase Expression

An Induction in Hepatic HDL Secretion Associated with Reduced ATPase Expression

Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages

Resveratrol increases hepatic SHBG expression through human constitutive androstane receptor: a new Contribution to the French Paradox

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