Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

Abstract

Taken together, our data suggest that resveratrol influences adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities. Thus, our findings open up the new perspective that resveratrol-induced intracellular pathways could be a target for prevention or treatment of obesity-associated endocrine and metabolic adverse effects.

Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

“…Adipogenesis is known as a hyperplastic transformation from undifferentiated pre-adipocytes to mature adipocytes and, lipogenesis, the convert and accumulation of lipid droplets in adipocyte from free fatty acids. Regarding the anti-adipogenic effects, several studies have demonstrated that resveratrol inhibited adipogenesis at concentrations of 20 to 100 μM and in the treatment period length (24 hr to 8 days) [36][37][38][39]. Our results show that resveratrol attenuated adipogenesis and lipogenesis at concentrations of 1 to 10 μM which is much less than the above published studies.…”

“…Our study revealed distinct and much more dynamic actions of resveratrol on both high-fat diet obese mice and 3T3-L1 cells conferred by a wide range of concentrations, as compared to previous studies [35][36][37][38][39][40][41]. At low concentrations (below 10 μM), resveratrol appears to inhibit adipogenic differentiation and lipolysis.…”

Studies on Mechanistic Role of Natural Bioactive Compounds in the Management of Obesity An Overview

“…The results of the in vitro studies, as shown in Table 1, indicate that resveratrol exerts the following beneficial effects on obesity management: a decrease in lipid synthesis in adipocytes by PPAR-γ supression, an increase in lipolysis, and a reduction in lipid accumulation in maturing preadipocytes [38,39], through the inhibition of lipogenesis and differentiation of 3T3-L1 adipocytes via activation of AMPK in a dose-dependent manner [40], and in the inhibition of adipogenesis by means of GSH up-regulation [41].…”

“…Through the mechanisms described above, resveratrol may decrease the expression and secretion of proinflammatory adipokines such as IL-6, TNF-α and PAI-1 [42], increase the expression and secretion of adiponectin [43], and improve mitochondrial oxidative function by increasing sirtuin activity [38], mitochondrial biogenesis and fatty acid oxidation [39].…”

Three single nucleotide variants of the <i>SIRT1</i> gene are associated with overweight in a Chinese population: a case control study

“…However, another study found that resveratol did not activate SIRT1 [23]. Resveratrol's suppression of preadipocyte proliferation and differentiation was dependent on SIRT1 [24], whereas adipokine secretion was only partially dependent on SIRT1 modulation [2]. Resveratrol's effect on AMPK also plays a role in its modulation of insulin sensitivity [25].…”