Resveratrol reduces oxidative damage and inflammation in mice infected with<i>Trichinella spiralis</i>

Elgendy, Dina I.; Othman, Ahmad A.; Saad, Marwa A. Hasby; Soliman, Nema A.; Mwafy, Shorouk E.

doi:10.1017/s0022149x20000206

Cited by 19 publications

(25 citation statements)

References 79 publications

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“…Five histological sections per mouse were examined. The average score of ten low-power fields (100×) from each of the examined sections was then calculated (+1 = mild reaction; +2 = moderate reaction; and +3 = intense reaction) (Elgendy et al , 2020).…”

Section: Methodsmentioning

confidence: 99%

Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis

et al. 2021

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Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis. Overall, 50 Swiss albino male mice were divided into five groups, with ten mice in each group: negative control, positive control, albendazole combined with prednisolone, C. limon, and C. frutescens. Mice were sacrificed 7 and 35 days after infection, for intestinal and muscular phase analyses. Drug efficacies were parasitologically, biochemically, histopathologically and ultrastructurally assessed. Our results demonstrated the efficacy of C. frutescens and C. limon extracts as antiparasitic agents, showing a substantial decrease in adult and larval counts. Moreover, both extracts had the ability to decrease serum tumour necrosis factor-α levels during the intestinal and muscular phases. In addition to the improved histopathological changes in the small intestine and muscles, the destructive effects on adults and larvae were ultrastructurally evident on transmission electron microscopy. In conclusion, C. frutescens and C. limon extracts are promising remedies for the treatment of experimental trichinellosis, particularly, the C. frutescens extract.

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Section: Methodsmentioning

confidence: 99%

Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis

et al. 2021

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“…Natural products due to the large structural diversity of secondary metabolites and novel chemical structures; conventionally play a crucial role in the exploration of new therapeutics and are valuable sources over centuries [ 26 ]. Resveratrol, a type of Stilbene compound, is reported as a therapeutic agent for many infectious diseases which has been extensively used in many preclinical studies [ 27 – 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Elgendy et al declared that resveratrol at the concentration of 20 mg/kg BW once daily for two weeks reduces oxidative damage and inflammation in mice infected with Trichinella spiralis [ 30 ]. We evaluated the probably toxic effects of the drugs used in the current study by assessing the cytotoxicity on L929 cell line, hemolysis on human red blood cells, and also the biochemical parameters to find possibly toxic effects and all these results confirmed the safety of resveratrol and RNE.…”

Section: Discussionmentioning

confidence: 99%

Anti-leishmanial effects of resveratrol and resveratrol nanoemulsion on Leishmania major

et al. 2022

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Background Leishmaniasis is a vector-borne disease that is endemic in the tropical and sub-tropical areas of the world. Low efficacy and high cytotoxicity of the current treatment regimens for leishmaniasis is one of the most important health problems. In this experimental study, anti-leishmanial effects of different concentrations of resveratrol and resveratrol nano-emulsion (RNE) were assessed. Methods RNE was prepared using the probe ultra-sonication method. The cytotoxicity was evaluated using the MTT technique on the L929 cell line. The anti-leishmanial activities on promastigotes of leishmania were assessed using vital staining and infected BALB/c mice were used to assess the in vivo anti-leishmanial effects. Results In vitro and in vivo assays revealed that all concentrations of resveratrol and RNE had valuable inhibitory effects against Leishmania major in comparison to the control group (P < 0.05). The half maximal inhibitory concentration (IC50) values were calculated as 16.23 and 35.71 µg/mL for resveratrol and RNE, respectively. Resveratrol and RNE showed no cytotoxicity against the L929 cell line. Conclusions According to the potent in vitro and in vivo anti-leishmanial activity of RNE at low concentration against L. major, we suggest that it could be a promising anti-leishmanial therapeutic against L. major in the future.

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“…Cancer cells become chemotherapy-resistant when this factor is present, allowing them to multiply. RSV inhibits this transcription factor, allowing chemotherapeutics to meet their intended targets [50][51][52]. RSV's anticancer molecular pathway [53] The stilbene family contains RSV, which is a pleiotropic phytochemical.…”

Section: Anticancer Activitymentioning

confidence: 99%

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2022

Drug Res (Stuttg)

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Resveratrol (RSV), the most effective stilbene phytoalexin synthesized naturally or induced in plants as part of their defense mechanism, is a key component of natural phenolic compounds and is being considered as a treatment option for a variety of diseases. RSV was discovered in the skin of red grapes, mulberries, peanuts, pines, and Polygonum cuspidatum weed root extracts. It was first extracted from white hellebore (Veratrum grandiflorum O. Loes) roots in 1940, then from Polygonum cuspidatum roots in 1963. However, RSV's use as a drug is limited due to its initial conformational strength and poor stability. The research focused on a set of RSV biological activity data. RSV has been the subject of growing concern, despite its wide range of biological and therapeutic applications. According to the literature, RSV has antioxidant, anticancer, cardioprotective, neuroprotective, anti-inflammatory, anti-microbial, immunomodulatory, and radioprotective properties. The current analysis summarized biological applications of RSV, their mechanisms of action, and recent scientific development in the area of their delivery. It is possible to infer that RSV has many effects on infected cells' cellular functions.

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Resveratrol reduces oxidative damage and inflammation in mice infected withTrichinella spiralis

Cited by 19 publications

References 79 publications

Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis

Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis

Anti-leishmanial effects of resveratrol and resveratrol nanoemulsion on Leishmania major

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