Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways

Benedetti, Francesca; Sorrenti, Vincenzo; Buriani, Alessandro; Fortinguerra, Stefano; Scapagnini, Giovanni; Zella, Davide

doi:10.3390/v12121458

Cited by 15 publications

(13 citation statements)

References 199 publications

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“…Resveratrol has shown antiviral activity against several viruses, such as polyomavirus, influenza virus, respiratory syncytial virus, MERS-CoV, and the emerging SARS-CoV [61]. The mechanisms of action of three important compounds (resveratrol, rapamycin, and metformin) on the cellular pathways involved in viral replication and the mechanisms of virus-related diseases, as well as the current status of their clinical use, were discussed [62]. The antiviral effect of resveratrol against MERS-CoV was evaluated through antiapoptotic and viral titer assays.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Shafreen¹,

Lakshmi

Pandian

et al. 2021

Molecules

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Previous reports have shown that consumption of wine has several health benefits; however, there are different types of wine. In the present study, red wines were investigated for their compositions of active ingredients. The interaction of each component in terms of its binding mode with different serum proteins was unraveled, and the components were implicated as drug candidates in clinical settings. Overall, the study indicates that red wines have a composition of flavonoids, non-flavonoids, and phenolic acids that can interact with the key regions of proteins to enhance their biological activity. Among them, rutin, resveratrol, and tannic acid have shown good binding affinity and possess beneficial properties that can enhance their role in clinical applications.

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Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Shafreen¹,

Lakshmi

Pandian

et al. 2021

Molecules

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“…This is the first, to our knowledge, evaluation among patients utilizing metformin documenting an influenza treatment response. Our research selected and evaluated metformin based upon preclinical data [7,9,17]. Specifically, published data suggest that an alteration in the metabolic profile of T cells in individuals with obesity impairs the activation of the adaptive immune cells [7,9].…”

Section: Discussionmentioning

confidence: 99%

Patients with Obesity and a History of Metformin Treatment Have Lower Influenza Mortality: A Retrospective Cohort Study

et al. 2022

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Background: Obesity is a risk factor for the development of influenza by leading to a chronic inflammatory state and T-cell dysfunction. Based upon preclinical research, metformin has influenza activity by restoring T-cell function and improving the immune response. Objective: We aimed to evaluate the potential drug repurposing of metformin for the management of influenza among patients with obesity utilizing national claims data in an electronic health record database. Methods: The VA Informatics and Computing Infrastructure (VINCI) was utilized to obtain individual-level information on demographics, administrative claims, and pharmacy dispensation. A cohort was created among individuals with laboratory confirmed diagnosis of influenza with a diagnosis of fever, cough, influenza, or acute upper respiratory infection in an outpatient setting. The study outcome was death after diagnosis of influenza. Cohorts were formed using diabetes status and metformin exposure prior to a positive influenza diagnosis. Hazard ratios for mortality were estimated using a cox proportional hazards model adjusting for baseline covariates and a sub-analysis was conducted utilizing propensity score matching. A greedy nearest neighbor algorithm was utilized to match 1 to 1 non-metformin diabetic controls and non-diabetic controls to diabetic patients receiving metformin. Results: A total of 3551 patients met the inclusion criteria and were evaluated in our study. The cohorts consisted of 1461 patients in the non-diabetic cohort, 1597 patients in the diabetic / metformin cohort, and 493 patients in the diabetic no metformin cohort. Compared to non-diabetic patients, diabetic patients with metformin had a lower rate of death (aHR 0.78, 95% CI 0.609–0.999). There was not a statistical difference between the non-diabetic patients and the diabetic patients without metformin (aHR 1.046, 95% CI 0.781–1.400). The propensity score matched cohorts revealed consistent results with the primary analysis. Conclusion: Our results demonstrated patients with obesity and a history of metformin treatment have lower influenza mortality.

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“…Many studies have stressed the antiviral functions of resveratrol both in vivo and in vitro ( 132 ). Xu et al ( 100 ) has revealed that resveratrol alleviates duck viral enteritis (an acute, contagious and herpesvirus infection of poultry intestine) through suppressing the multiplication of duck enteritis virus in host cells.…”

Section: Resveratrol and Intestinal Diseasesmentioning

confidence: 99%

Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier

Wang

Hong

et al. 2022

Front. Nutr.

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The integrity of intestinal barrier determines intestinal homeostasis, which could be affected by various factors, like physical, chemical, and biological stimuli. Therefore, it is of considerable interest and importance to maintain intestinal barrier function. Fortunately, many plant polyphenols, including resveratrol, could affect the health of intestinal barrier. Resveratrol has many biological functions, such as antioxidant, anti-inflammation, anti-tumor, and anti-cardiovascular diseases. Accumulating studies have shown that resveratrol affects intestinal tight junction, microbial composition, and inflammation. In this review, we summarize the effects of resveratrol on intestinal barriers as well as the potential mechanisms (e.g., inhibiting the growth of pathogenic bacteria and fungi, regulating the expression of tight junction proteins, and increasing anti-inflammatory T cells while reducing pro-inflammatory T cells), and highlight the applications of resveratrol in ameliorating various intestinal diseases.

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Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways

Cited by 15 publications

References 199 publications

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

In Vitro and In Silico Interaction Studies with Red Wine Polyphenols against Different Proteins from Human Serum

Patients with Obesity and a History of Metformin Treatment Have Lower Influenza Mortality: A Retrospective Cohort Study

Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier

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