Resveratrol Protects Vascular Endothelial Cells from High Glucose–Induced Apoptosis through Inhibition of <scp>NADPH</scp> Oxidase Activation–Driven Oxidative Stress

Chen, Feng; Qian, Lei; Deng, Bo; Liu, Zhimin; Zhao, Ying; Le, Yingying

doi:10.1111/cns.12131

Cited by 88 publications

(66 citation statements)

References 35 publications

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“…Similarly, resveratrol has been shown to protect endothelial cells by inhibiting NADPH-oxidase and attenuating ROS production [112,113]. Resveratrol also counteracts 7-oxo-cholesterol-induced inflammation and NF-κB activation in human macrophages, suggesting an important role of resveratrol to protect against the pro-atherogenic effect of oxysterols [114].…”

Section: Preclinical Studiesmentioning

confidence: 99%

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

Zordoky

Robertson

Dyck

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

270

212

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Cardiovascular disease is the leading cause of death worldwide. Despite advancements in diagnosis and treatment of cardiovascular disease, the incidence of cardiovascular disease is still rising. Therefore, new lines of medications are needed to treat the growing population of patients with cardiovascular disease. Although the majority of the existing pharmacotherapies for cardiovascular disease are synthesized molecules, natural compounds, such as resveratrol, are also being tested. Resveratrol is a non-flavonoid polyphenolic compound, which has several biological effects. Preclinical studies have provided convincing evidence that resveratrol has beneficial effects in animal models of hypertension, atherosclerosis, stroke, ischemic heart disease, arrhythmia, chemotherapy-induced cardiotoxicity, diabetic cardiomyopathy, and heart failure. Although not fully delineated, some of the beneficial cardiovascular effects of resveratrol are mediated through activation of silent information regulator 1 (SIRT1), AMP-activated protein kinase (AMPK), and endogenous anti-oxidant enzymes. In addition to these pathways, the anti-inflammatory, anti-platelet, insulin-sensitizing, and lipid-lowering properties of resveratrol contribute to its beneficial cardiovascular effects. Despite the promise of resveratrol as a treatment for numerous cardiovascular diseases, the clinical studies for resveratrol are still limited. In addition, several conflicting results from trials have been reported, which demonstrates the challenges that face the translation of the exciting preclinical findings to humans. Herein, we will review much of the preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular disease and provide information about the physiological and molecular signaling mechanisms involved. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

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Section: Preclinical Studiesmentioning

confidence: 99%

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

Zordoky

Robertson

Dyck

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

270

212

View full text Add to dashboard Cite

show abstract

“…Other natural compounds (e.g. melatonin and resveratrol) are known to rescue vascular dysfunctions by the inhibition of NADPH oxidase, a major source of ROS, and the activity of antioxidant enzymes such as Cu,Zn SOD, catalase and GSH peroxidase [147,148,149]. …”

Section: Role Of Copper Transport Systems During Angiogenesismentioning

confidence: 99%

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Urso

Maffia²

2015

J Vasc Res

115

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Angiogenesis critically sustains the progression of both physiological and pathological processes. Copper behaves as an obligatory co-factor throughout the angiogenic signalling cascades, so much so that a deficiency causes neovascularization to abate. Moreover, the progress of several angiogenic pathologies (e.g. diabetes, cardiac hypertrophy and ischaemia) can be tracked by measuring serum copper levels, which are being increasingly investigated as a useful prognostic marker. Accordingly, the therapeutic modulation of body copper has been proven effective in rescuing the pathological angiogenic dysfunctions underlying several disease states. Vascular copper transport systems profoundly influence the activation and execution of angiogenesis, acting as multi-functional regulators of apparently discrete pro-angiogenic pathways. This review concerns the complex relationship among copper-dependent angiogenic factors, copper transporters and common pathological conditions, with an unusual accent on the multi-faceted involvement of the proteins handling vascular copper. Functions regulated by the major copper transport proteins (CTR1 importer, ATP7A efflux pump and metallo-chaperones) include the modulation of endothelial migration and vascular superoxide, known to activate angiogenesis within a narrow concentration range. The potential contribution of prion protein, a controversial regulator of copper homeostasis, is discussed, even though its angiogenic involvement seems to be mainly associated with the modulation of endothelial motility and permeability.

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“…Liu et al (Liu et al , 2015b) demonstrated that resveratrol protected PC12 cells from HG-induced neurotoxicity via the PI3K/Akt/FoxO3a pathway, and that resveratrol inhibited HG-induced collagen upregulation in cardiac fibroblasts through regulation of TGF-1-Smad3 signaling (Liu et al , 2015a). Chen et al (Chen et al , 2013) declared that resveratrol protected vascular endothelial cells from HG-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress, whereas Mohamed et al (Mohamed et al , 2014) showed that the neuroprotective effect of resveratrol in diabetic cerebral ischemia-reperfused rats was through regulation of inflammatory and apoptotic events. Together, these studies demonstrated that various mechanisms were responsible for the protective effects of resveratrol on oxidative stress injury.…”

mentioning

confidence: 99%

Resveratrol ameliorates high glucose-induced oxidative stress injury in human umbilical vein endothelial cells by activating AMPK

Zhou

Gao

et al. 2015

Life Sciences

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Resveratrol Protects Vascular Endothelial Cells from High Glucose–Induced Apoptosis through Inhibition of NADPH Oxidase Activation–Driven Oxidative Stress

Abstract: HG induces endothelial cell apoptosis through NF-κB/NADPH oxidase/ROS pathway, which was inhibited by resveratrol. Our findings provide new potential therapeutic targets against brain vascular complications of diabetes.

Cited by 88 publications

References 35 publications

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

Behind the Link between Copper and Angiogenesis: Established Mechanisms and an Overview on the Role of Vascular Copper Transport Systems

Resveratrol ameliorates high glucose-induced oxidative stress injury in human umbilical vein endothelial cells by activating AMPK

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