Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol

Ranney, Alyssa; Petro, Marilyn S.

doi:10.1097/fbp.0b013e32832f0193

Cited by 37 publications

(24 citation statements)

References 33 publications

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“…Similar protective effects of resveratrol on dopaminergic system has been reported against injuries caused by LPS, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or 6-hydroxyl dopamine (Rose et al 2014;Blanchet et al 2008;Lofrumento et al 2014;Wang et al 2011). Additionally, some works describe an increased TH expression due to resveratrol treatment, pointing out a SIRT1-mediated effect, which, in turn, could also imply histone deacetylation-mediated effects (Chen et al 2007;Kumar et al 2007;Ranney and Petro 2009;Tredici et al 1999). Thus, SIRT1 activation could be part of the action mechanism for resveratrol pharmacological activities, including a cellular ROS scavenging effect (Araki et al 2004;Li et al 2014).…”

Section: Discussionmentioning

confidence: 81%

Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats

Sarubbo

Ramis

Aparicio

et al. 2015

AGE

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Resveratrol is a polyphenol exhibiting antioxidant and neuroprotective effects in neurodegenerative diseases. However, neuroprotective properties during normal aging have not been clearly demonstrated. We analyzed the in vivo effects of chronic administration of resveratrol (20 mg/kg/day for 4 weeks) in old male rats (Wistar, 20 months), on tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activities which mediate central monoaminergic neurotransmitters synthesis, and besides, on hippocampal-dependent working memory test (radial maze). Our results show an age-related decline in neurochemical parameters that were reversed by resveratrol administration. The resveratrol treatment enhances serotonin (5-HT) levels in pineal gland, in hippocampus, and in striatum, and those of noradrenaline (NA) in hippocampus and also dopamine (DA) in striatum. These changes were largely due to an increased activity of TPH-1 (463 % in pineal gland), TPH-2 (70-51 % in hippocampus and striatum), and TH (150-36 % in hippocampus and striatum).Additionally, the observed hippocampal effects correlate with a resveratrol-induced restorative effect on working memory (radial maze). In conclusion, this study suggests resveratrol treatment as a restoring therapy for the impaired cognitive functions occurring along normal aging process, by preventing 5-HT, DA, and NA neurotransmission decline.

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Section: Discussionmentioning

confidence: 81%

Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats

Sarubbo

Ramis

Aparicio

et al. 2015

AGE

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“…Non-steroidal anti-inflammatory drugs, like celecoxib, have been shown to improve hippocampal-dependent learning in middle aged rats concurrent with a reduction in hippocampal cytokine levels (Casolini et al, 2002). Improvements in cognitive function, synaptic strength, and/or LTP have also been reported for aged rodents exposed to a variety of other anti-inflammatory treatments including minocycline (Griffin et al, 2006), resveratrol (Joseph et al, 2008; Ranney and Petro, 2009) and flavonoid-rich diets (Coultrap et al, 2008; Goyarzu et al, 2004; Malin et al, 2011). …”

Section: Neuroinflammationmentioning

confidence: 96%

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

Sama¹,

Norris²

2013

Ageing Research Reviews

101

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Some of the best biomarkers of age-related cognitive decline are closely linked to synaptic function and plasticity. This review highlights several age-related synaptic alterations as they relate to Ca2+ dyshomeostasis, through elevation of intracellular Ca2+, and neuroinflammation, through production of pro-inflammatory cytokines including interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). Though distinct in many ways, Ca2+ and neuroinflammatory signaling mechanisms exhibit extensive cross-talk and bidirectional interactions. For instance, cytokine production in glial cells is strongly dependent on the Ca2+ dependent protein phosphatase calcineurin, which shows elevated activity in animal models of aging and disease. In turn, pro-inflammatory cytokines, such as TNF, can augment the expression/activity of L-type voltage sensitive Ca2+ channels in neurons, leading to Ca2+ dysregulation, hyperactive calcineurin activity, and synaptic depression. Thus, in addition to discussing unique contributions of Ca2+ dyshomeostasis and neuroinflammation, this review emphasizes how these processes interact to hasten age-related synaptic changes.

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“…Resveratrol mimics caloric restriction by extending the lifespan of several small organisms (Baur & Sinclair, 2006; Greet & Brunet, 2009), and by delaying specific age-related phenotypes, e.g., abnormal glucose metabolism (Poulsen, et al, 2013). Resveratrol is also thought to beneficially influence cognitive deterioration (Ranney & Petro, 2009; Abraham & Johnson, 2009). Clinical studies are underway to explore the benefits of resveratrol for treating individuals with dementia, particularly those characterized by mild cognitive impairment (MCI), a clinical condition that eventually progresses to AD.…”

Section: Resveratrol Inflammation and Type 2 Diabetes: Implicationsmentioning

confidence: 99%

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

Pasinetti

Wang

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

203

126

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Alzheimer’s disease (AD) is a devastating disorder that strikes 1 in 10 Americans over the age of 65, and almost half of all Americans over 85 years old. The odds of an individual developing Alzheimer’s disease double every five years after the age of 65. While it has become increasingly common to meet heart attack or cancer survivors, there are no Alzheimer’s disease survivors. There is mounting evidence that dietary polyphenols, including resveratrol, may beneficially influence Alzheimer’s disease (AD). Based on this consideration, several studies reported in the last few years were designed to validate sensitive and reliable translational tools to mechanistically characterize brain bioavailable polyphenols as disease-modifying agents to help prevent the onset of AD dementia and other neurodegenerative disorders. Several research groups worldwide with expertise in AD, plant biology, nutritional sciences, and botanical sciences have reported very high quality studies that ultimately provided the necessary information showing that polyphenols and their metabolites, which come from several dietary sources, including grapes, cocoa etc., are capable of preventing AD. The ultimate goal of these studies was to provide novel strategies to prevent the disease even before the onset of clinical symptoms. The studies discussed in this review article provide support that the information gathered in the last few years of research will have a major impact on AD prevention by providing vital knowledge on the protective roles of polyphenols, including resveratrol.

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Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol

Cited by 37 publications

References 33 publications

Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats

Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

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