Resveratrol Promotes Foot Ulcer Size Reduction in Type 2 Diabetes Patients

Bashmakov, Yuriy K.; Assaad-Khalil, S.; Seif, Myriam Abou; Udumyan, Ruzan; Megallaa, Magdy Helmy; Rohoma, Kamel Hemida; Zeitoun, Moustafa M.; Petyaev, Ivan M.

doi:10.1155/2014/816307

Cited by 92 publications

(89 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The anti-acneic property of RSV in volunteers with acne vulgaris has also been reported (Fabbrocini et al, 2011). Of significance, RSV treatment (one capsule containing 50 mg of trans-RSV given twice daily over a 60-day period) promoted a reduction in foot ulcer size in T2DM patients (Bashmakov et al, 2014). …”

Section: Resveratrol and Skin Disordersmentioning

confidence: 99%

Resveratrol supplementation: Where are we now and where should we go?

Novelle¹,

Wahl²,

Diéguez³

et al. 2015

Ageing Research Reviews

208

149

View full text Add to dashboard Cite

Pre-clinical findings have provided mounting evidence that resveratrol, a dietary polyphenol, may confer health benefits and protect against a variety of medical conditions and age-related complications. However, there is no consistent evidence of an increased protection against metabolic disorders and other ailments when comparing studies in laboratory animals and humans. A number of extraneous and potential confounding variables can affect the outcome of clinical research. To date, most of the studies that have investigated the effect of resveratrol administration on patient outcomes have been limited by their sample sizes. In this review we will survey the latest advances regarding the timing, dosage, formulation, bioavailability, and toxicity of resveratrol, and resveratrol-drug interactions in human studies. Moreover, the present report focuses on the actions of resveratrol treatment in combatting diseases, such as cancer, diabetes, neurodegeneration, cardiovascular disease, and other age-related ailments.

show abstract

Section: Resveratrol and Skin Disordersmentioning

confidence: 99%

Resveratrol supplementation: Where are we now and where should we go?

Novelle¹,

Wahl²,

Diéguez³

et al. 2015

Ageing Research Reviews

208

149

View full text Add to dashboard Cite

show abstract

“…RSV treatment in type 2 diabetic patients with newly diagnosed diabetic foot ulcers resulted in a reduction of diabetic ulcer size and plasma fibrinogen level [361].…”

Section: Rsv-enriched (8 Mg) Grape Extract (Ge-rsv) Supplementation Fmentioning

confidence: 93%

The pharmacology of resveratrol in animals and humans

Park

Pezzuto

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

249

193

View full text Add to dashboard Cite

In addition to thousands of research papers related to resveratrol (RSV), approximately 300 review articles have been published. Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems, inflammation, and carcinogenesis/cancer development. More recently, the horizon has been broadened by exploring the potential effect of RSV on the aging process, diabetes, neurological dysfunction, etc. Herein, we primarily focus on the in vivo pharmacological effects of RSV reported over the past 5 years (2009-2014). In addition, recent clinical intervention studies performed with resveratrol are summarized. Some discrepancies exist between in vivo studies with animals and clinical studies, or between clinical studies, which are likely due to disparate doses of RSV, experimental settings, and subject variation. Nevertheless, many positive indications have been reported with mammals, so it is reasonable to advocate for the conduct of more definitive clinical studies. Since the safety profile is pristine, an added advantage is the use of RSV as a dietary supplement. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

show abstract

“…Although numerous data exist on the beneficial outcomes of RSV in diabetic animals and in vitro , limited studies have specifically investigated the antidiabetic effects of RSV in humans [16, 111–113]. A vast majority of clinical studies on the effects of RSV have focused on healthy individuals or other metabolic disorders but there is paucity of comprehensive information on its effects in diabetic humans (Table 2).…”

Section: Clinical Studies On the Effects Of Resveratrol In Diabetementioning

confidence: 99%

“…It is interesting to note that the data obtained from majority of the clinical studies carried out in DM have been consistent with the promising results from animal models. One of these studies also reported improvement in diabetes complication (foot ulcer) after RSV treatment [113]. …”

Section: Clinical Studies On the Effects Of Resveratrol In Diabetementioning

confidence: 99%

Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

Oyenihi

Adeyanju

et al. 2016

Journal of Diabetes Research

View full text Add to dashboard Cite

Despite recent advances in the understanding and management of diabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessitated the search for novel therapeutic agents. Due to the multipathogenicity of diabetes mellitus, plant-derived compounds with proven multiple pharmacological actions have been postulated to “hold the key” in the search for an affordable, efficacious, and safer therapeutic agent in the treatment of the disease and associated complications. Resveratrol, a phytoalexin present in few plant species, has demonstrated beneficial antidiabetic effects in animals and humans through diverse mechanisms and multiple molecular targets. However, despite the enthusiasm and widespread successes achieved with the use of resveratrol in animal models of diabetes mellitus, there are extremely limited clinical data to confirm the antidiabetic qualities of resveratrol. This review presents an update on the mechanisms of action and protection of resveratrol in diabetes mellitus, highlights challenges in its clinical utility, and suggests the way forward in translating the promising preclinical data to a possible antidiabetic drug in the near future.

show abstract

Resveratrol Promotes Foot Ulcer Size Reduction in Type 2 Diabetes Patients

Cited by 92 publications

References 25 publications

Resveratrol supplementation: Where are we now and where should we go?

Resveratrol supplementation: Where are we now and where should we go?

The pharmacology of resveratrol in animals and humans

Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

Contact Info

Product

Resources

About