Resveratrol promotes bone mass in ovariectomized rats and the SIRT1 rs7896005 SNP is associated with bone mass in women during perimenopause and early postmenopause

Wang, Xue; Lu, Cheng Wei; Chen, Yijie; Wang, Q; Bao, Xiaogang; Zhang, Z; Huang, Xin

doi:10.1080/13697137.2022.2073809

Cited by 6 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… BV/TV Analysis of 18 studies [ 15 , 25 – 27 , 30 , 33 , 35 – 38 , 40 , 41 ] showed that, compared with those in the control group, the BV/TV in the Res group was markedly greater ( n = 252; SMD, 1.44; 95% CI, 0.68 to 2.19; I 2 = 80%, P < 0.001). Tb.N Analysis of 18 studies [ 19 , 25 – 27 , 33 , 35 – 38 , 40 , 41 ] showed that, compared with the control group, the Res group had markedly greater total bilirubin (Tb.N) ( n = 242; SMD, 1.68; 95% CI, 0.95 to 2.42; I 2 = 74%, P < 0.00001). Tb.Th Analysis of 18 studies [ 19 , 25 , 26 , 30 , 33 , 35 – 37 , 40 , 41 ] showed that, compared with that in the control group, the Tb.Th in the Res group was markedly greater ( n = 248; SMD, 1.73; 95% CI, 1.09 to 2.37; I 2 = 71%, P < 0.00001).…”

Section: Secondary Outcomesmentioning

confidence: 99%

“… Tb.Th Analysis of 18 studies [ 19 , 25 , 26 , 30 , 33 , 35 – 37 , 40 , 41 ] showed that, compared with that in the control group, the Tb.Th in the Res group was markedly greater ( n = 248; SMD, 1.73; 95% CI, 1.09 to 2.37; I 2 = 71%, P < 0.00001). Tb.Sp Analysis of 20 studies [ 19 , 25 – 27 , 30 , 33 , 35 – 38 , 40 , 41 ] showed that, compared with that in the control group, the Tb.Sp in the Res group was markedly lower ( n = 278; SMD, − 1.76; 95% CI, − 2.35 to − 1.16; I 2 = 70%, P < 0.00001). …”

Section: Secondary Outcomesmentioning

confidence: 99%

“…Analysis of 20 studies [ 19 , 25 – 27 , 30 , 33 , 35 – 38 , 40 , 41 ] showed that, compared with that in the control group, the Tb.Sp in the Res group was markedly lower ( n = 278; SMD, − 1.76; 95% CI, − 2.35 to − 1.16; I 2 = 70%, P < 0.00001).…”

Section: Secondary Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

An,

Luo,

et al. 2024

J Orthop Surg Res

View full text Add to dashboard Cite

Background There is still a lack of sufficient evidence-based medical data on the effect of resveratrol (Res) on primary osteoporosis (OP). This meta-analysis aimed to comprehensively evaluate the role of Res in animal models of primary OP. Methods The PubMed, Cochrane Library, Web of Science and Embase databases were searched up to August 2023. The risk of bias was assessed by the SYRCLE RoB tool. Random- or fixed-effects models were used to determine the 90% confidence interval (CI) or standardized mean difference (SMD). Statistical analysis was performed with RevMan 5.4 and Stata 14.0. Results A total of 24 studies containing 714 individuals were included. Compared with those in the control group, the bone mineral density (BMD) (P < 0.00001), bone volume/total volume (BV/TV) (P < 0.001), trabecular thickness (Tb.Th) (P < 0.00001), and trabecular number (Tb.N) (P < 0.00001) were markedly greater, and the trabecular separation (Tb.Sp) (P < 0.00001) was significantly greater. Compared with the control group, the Res group also exhibited marked decreases in alkaline phosphatase (ALP) (P < 0.05), tartrate-resistant acid phosphatase 5b (TRAP5b) (P < 0.01), and type I collagen strong carboxyl peptide (CTX-1) (P < 0.00001) and a marked increase in osteoprotegerin (OPG) (P < 0.00001). Conclusion In summary, we concluded that Res can markedly increase BMD, improve morphometric indices of trabecular microstructure and serum bone turnover markers (BTMs), and exert a protective effect in animal models of primary osteoporosis. This study can supply experimental reference for Res in primary osteoporosis treatment.

show abstract

Section: Secondary Outcomesmentioning

confidence: 99%

Section: Secondary Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

An,

Luo,

et al. 2024

J Orthop Surg Res

View full text Add to dashboard Cite

show abstract

“…RES positively regulates osteogenic differentiation by inhibiting the expression of miRNA-338-3p and inhibits osteoclast proliferation by stimulating the expression of miRNA-92-b-3p [26,27] . The oral administration of RES to OVX rats and post-menopausal women improves the bone loss due to estrogen-deficiency, increases bone mass and reduces bone resorption [25] . Moreover, RES intake increases bone mass in women who do not take calcium or vitamin D and strengthens the increase of lumbar BMD in women who take calcium and/or vitamin D [28] .…”

Section: Resveratrol and Curcuminmentioning

confidence: 99%

“…Studies in vitro demonstrated that RES exerts its anti-osteoporotic effect by inhibiting the p53 signalling pathway [22] , improving the osteogenic differentiation into BM-SCs [23] and up-regulating FOXO1 transcriptional activity [24] . OPG and β-catenin are increased by RES that, on the contrary, decreases RANKL by stimulating Sirt-1 expression [24,25] . RES positively regulates osteogenic differentiation by inhibiting the expression of miRNA-338-3p and inhibits osteoclast proliferation by stimulating the expression of miRNA-92-b-3p [26,27] .…”

Section: Resveratrol and Curcuminmentioning

confidence: 99%

Dietary polyphenols and osteoporosis: molecular mechanisms involved

Iantomasi

Palmini

Romagnoli

et al. 2022

International Journal of Bone Fragility

View full text Add to dashboard Cite

Osteoporosis is related to dysfunction of the crosstalk between osteoblasts and osteoclasts, the cells involved in the formation and resorption of bone, respectively. Oxidative stress and inflammation are involved in the pathogenesis of osteoporosis. Because of their antioxidant and anti-inflammatory properties, natural compounds such as polyphenols extensively present in fruit, vegetables, wine, tea, extra virgin olive oil, and berries, play an important protective role in disorders of bone metabolism, including osteoporosis. A diet rich in polyphenol-rich fruit and vegetables can reduce bone mineral density loss, decreasing the risk of fracture and preserving lifestyle quality. The aim of the present review is to highlight the principal mechanisms involved in the role played by the main dietary polyphenols in the prevention and/or treatment of osteoporosis.

show abstract

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Li²,

Li³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Bone reconstruction includes a steady state system of bone formation and bone absorption. This tight coupling requires subtle coordination between osteoblasts and osteoclasts. If this balance is broken, it will lead to bone mass loss, bone density reduction, and bone metabolic diseases, such as osteoporosis. Polyphenols in Chinese herbal medicines are active ingredients in plant extracts with high safety and few side effects, and they can play a role in affecting bone formation and bone resorption. Some of these have estrogen-like effects and can better target bone health in postmenopausal women. The purpose of this review is to provide comprehensive information on the mechanisms underlying the relationship between traditional Chinese medicine polyphenols and bone formation or bone resorption.

show abstract

Resveratrol promotes bone mass in ovariectomized rats and the SIRT1 rs7896005 SNP is associated with bone mass in women during perimenopause and early postmenopause

Cited by 6 publications

References 35 publications

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

Dietary polyphenols and osteoporosis: molecular mechanisms involved

A mechanistic review of chinese medicine polyphenols on bone formation and resorption

Contact Info

Product

Resources

About