Resveratrol prevents cognitive deficits induced by sleep deprivation via modulating sirtuin 1 associated pathways in the hippocampus
Yue‐Ming Zhang,
Ru‐Meng Wei,
Jing‐Ya Zhang
et al.
Abstract:Accumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti‐inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation‐induced cognitive deficits and its underlying molecular mechanisms are unclear. In the present study, thirty‐two m… Show more
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