Resveratrol prevents akinesia and restores neuronal tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta of diabetic rats

Bagatini, Pamela Brambilla; Xavier, Léder Leal; Neves, Laura Tartari; Saur, Lisiani; Barbosa, Sílvia; Baptista, Pedro Porto Alegre; Augustin, Otávio Américo; Senna, Priscylla Nunes de; Mestriner, Régis Gemerasca; Souto, André A.; Achaval, Matilde

doi:10.1016/j.brainres.2014.10.007

Cited by 9 publications

(4 citation statements)

References 56 publications

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“…The consequent high blood glucose levels lead to marked polyuria, polydipsia, and weight loss. In the present study, all these features were observed in the diabetic rats, and treatment with resveratrol was unable to influence the blood glucose levels or body weight of the diabetic and non-diabetic rats, as previous studies have shown [14,19,21].…”

Section: Discussioncontrasting

confidence: 42%

“…From D30 to D64, oral treatment was provided to all groups once a day, between 10:00 and 11:00 a.m., totaling 35 days of treatment. Resveratrol was freshly dispersed in 0.9% saline solution and promptly administered via oral gavage to animals belonging to the ND RSV groups and the D RSV groups, in their respective doses, based on previous studies [14,21]. Animals from the ND SAL and D SAL groups received equal volumes of 0.9% saline solution alone.…”

Section: Oral Gavagementioning

confidence: 99%

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An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

Bagatini

Xavier

Bertoldi

et al. 2017

Neuroscience Letters

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Section: Discussioncontrasting

confidence: 42%

Section: Oral Gavagementioning

confidence: 99%

An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

Bagatini

Xavier

Bertoldi

et al. 2017

Neuroscience Letters

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“…[42][43][44][45] Some researchers, however, have observed a contrary effect where treatment with resveratrol at 10 mg or 20 mg per kg body weight was unable to influence the blood glucose levels of diabetic rats. [46][47][48][49][50] The lack of effect on reduction of blood glucose may be explained by a substantial damage of β-cells by STZ whereby resveratrol failed to correct the insulin secretion and rats remained to be hyperglycemic.…”

Section: Discussionmentioning

confidence: 99%

The antioxidant effect of mulberry and jamun fruit wines by ameliorating oxidative stress in streptozotocin-induced diabetic Wistar rats

et al. 2016

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Polyphenols act by scavenging reactive oxygen species during oxidative stress and hence are useful in the treatment of metabolic disorders including diabetes. This study describes the effect of polyphenol rich mulberry and jamun wines fed to streptozotocin-induced diabetic rats. To male adult Wistar rats, divided into groups (n = 10 per group) intraperitoneal injection was administered with streptozotocin at 38 mg per kg body weight for inducing diabetes. After confirmation of diabetes, rats divided into groups were fed each day with 5.7 milliliter per kg body weight of mulberry, jamun, white and red grape wines for 6 weeks. One group of animals received resveratrol at 20 mg per kg body weight. After six weeks of treatment, blood glucose, urinary profile, lipid profile, plasma, liver, kidney, brain and eye antioxidant enzyme activities, lipid peroxidation, non-esterified fatty acids (NEFA) and hepatic glutathione (GSH) content were determined. Though wine and resveratrol feeding did not improve the glycemic status of diabetic rats, increases in antioxidant enzymes and GSH content accompanied by reduced NEFA and lipid peroxidation were observed. The kidneys and brains of resveratrol fed rats showed significant reduction in malondialdehyde equivalents, exhibited an improved antioxidant status of tissues and an increased glutathione content. The findings suggested that the wines can ameliorate the consequences of diabetes due to their antioxidants.

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“…In seeming contrast to our current data, others have noted an increase in TH immunoreactivity in the SN following resveratrol exposure. [76, 77] The distinction between these previous reports and our current observation is that these groups measured the intensity of the immunoreactivity, whereas we counted the number of TH+ neurons using a novel stereological approach. Moreover, in the previous studies, diabetic mice, rats, and young animals were administered resveratrol via gavage.…”

Section: Discussionmentioning

confidence: 87%

Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism

Allen

Potdar

Tapias

et al. 2018

The Journal of Nutritional Biochemistry

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Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.

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Resveratrol prevents akinesia and restores neuronal tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta of diabetic rats

Cited by 9 publications

References 56 publications

An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

An evaluation of aversive memory and hippocampal oxidative status in streptozotocin-induced diabetic rats treated with resveratrol

The antioxidant effect of mulberry and jamun fruit wines by ameliorating oxidative stress in streptozotocin-induced diabetic Wistar rats

Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism

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