Resveratrol: Potential as Anticancer Agent

Abstract

Resveratrol appears to have anticancer effects. Additionally, these studies indicate that resveratrol's chemoprevention effect is dose and duration dependent. It has synergistic effect with anticancer drugs in vitro. Further human studies need to be done.

E ects of di erent drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774

“…It was shown that grape seed extract and resveratrol at concentrations of 1 to 100 µM have varying degrees of cytotoxic and proapoptotic activity in several cancer cell lines (15). Other researchers showed that resveratrol may decrease the proliferation of tumor cells by inducing apoptosis (16)(17)(18).…”

Therapeutic Role of Resveratrol and Piceatannol in Disease Prevention

“…Anticancer Present Present Antileukaemic Present Present Table 1: Similar biological activities of resveratrol and piceatannol [11,[14][15][16][17][18][19]29,32,33,36].…”

“…It inhibits onset and promotion of cancer. It promotes anti-tumoral activity by inhibiting angiogenesis [17,18]. The anti-cancer effect of resveratrol is associated with the damage of mitochondrial function that leads to an increase in ROS (reactive oxygen species), apoptosis and possibly intracellular drug accumulation via inhibition of proteins involved in MDR (multi-drug resistance) [19].…”

“…Various mechanisms for the anticancer action of resveratrol include angiogenesis inhibition, cell cycle alteration, apoptosis and antioxidant effects. It also suppresses cytochrome P450 that is considered as procarcinogens [18,25].…”

Resveratrol Nanoparticle’s Formulation - In Diabetic Nephropathy

“…Cardioprotective, Anti-inflammatory, Antioxidant and Anticancer properties, also used in DN (Aluyen et al, 2012;Kraft et al, 2009;Jang et al 1997; Soni NOP 2017; Yang et al, 2014).…”