Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis
Ningning Diao,
Yan Liu,
Wenxin Wang
et al.
Abstract:Rheumatoid arthritis (RA) is a chronic destructive in ammatory synovitis that is associated with a wide range of clinical consequences, including comorbidities affecting systemic bone, vasculature, metabolic function, and cognition. Although Resveratrol (Res) has been shown to have pharmacological bene ts in the treatment of RA, its limited bioavailability and poor water solubility have prevented clinical usage of this substance. Therefore, changing the crystalline form of Res to boost its solubility and bioav… Show more
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