Resveratrol modulates innate and inflammatory responses in fish leucocytes

Castro, Rosario; Lamas, Jesús; Morais, Pedro Almir Feitosa; Sanmartín, M. L.; Orallo, Francisco; Leiro, J.

doi:10.1016/j.vetimm.2008.06.001

Cited by 43 publications

(37 citation statements)

References 43 publications

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“…The MPO content of leucocytes decreased in both groups of sea bass fed carvacrol (even if the difference was not significant), supporting the results obtained regarding the oxidative burst, as peroxidase activity is closely correlated to ROS production. The inhibition of intracellular and extracellular MPO was also observed in turbot leucocytes treated with resveratrol in vitro (Castro et al 2008). Pinocytosis is another major activity of macrophages.…”

Section: Discussionmentioning

confidence: 92%

“…The inhibition of intracellular and extracellular MPO was also observed in turbot leucocytes treated with resveratrol in vitro (Castro et al . ). Pinocytosis is another major activity of macrophages.…”

Section: Discussionmentioning

confidence: 97%

“…Resveratrol caused a significant decrease in ROS production by turbot ( Psetta maxima ) HK leucocytes stimulated in vitro with PMA, findings similar to that described in mammals. It was hypothesized that resveratrol penetrates cells and inhibits ROS production or acts as a ‘scavenger’, limiting oxidative stress (Castro, Lamas, Morais, Sanmartin, Orallo & Leiro ). Moreover, our results are consistent with those observed in catfish ( I .…”

Section: Discussionmentioning

confidence: 99%

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Growth parameters, innate immune response and resistance toListonella(Vibrio)anguillarumofDicentrarchus labraxfed carvacrol supplemented diets

et al. 2012

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The research was aimed to assess the effect of dietary carvacrol (0.025% and 0.05%) on sea bass (Dicentrarchus labrax) growth, immune response and resistance to Listonella anguillarum. Fish (69.2 ± 0.22 g) were fed the experimental diets for 9 weeks. Dietary carvacrol did not negatively affect fish survival, growth performance, feed intake and feed conversion ratio (P > 0.05) nor carcass yield and viscerosomatic, hepatosomatic and mesenteric fat index (P > 0.05). Serum and head kidney leucocytes were collected after 1, 4 and 8 weeks of feeding. Carvacrol significantly reduced serum proteins, immunoglobulins and lysozyme activity (P < 0.01) and moderately increased phagocytosis and pinocytosis of head kidney macrophages. The release of reactive oxygen species by leucocytes was reduced in carvacrol‐fed fish, even if significantly (P < 0.05) only in those fed 0.05% carvacrol for 1 week. Dietary carvacrol did not significantly affect the aspecific immune response, although a potential antioxidant activity might be speculated. Moreover, feeding carvacrol provided an appreciable resistance to a challenge with L. anguillarum, when a bacterial dose lower than the Lethal Dose50 was used. Cumulative mortality in fish fed 0.025% carvacrol was significantly lower than that of untreated controls (75% Relative Per cent Survival).

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Growth parameters, innate immune response and resistance toListonella(Vibrio)anguillarumofDicentrarchus labraxfed carvacrol supplemented diets

et al. 2012

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“…Resveratrol (RESV; trans‐3,5,40‐trihydroxystilbene), a natural polyphenol with well‐known anti‐oxidant, anti‐inflammatory and immunomodulatory activities, which is present in various plants, including grapes, berries and peanuts, was found to strongly inhibit intracellular and extracellular myeloperoxidase (MPO) activity, behaving as a non‐competitive and reversible inhibitor, and also caused a decrease in MPO mRNA levels in turbot ( Psetta maxima ) neutrophils (Castro et al. 2008).…”

Section: Differential Uses Of Phytochemicals In Finfish Culturementioning

confidence: 99%

Application of phytochemicals as immunostimulant, antipathogenic and antistress agents in finfish culture

Chakraborty¹,

Hancz²

2011

Reviews in Aquaculture

279

166

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Phytochemicals such as alkaloids, flavonoids, pigments, phenolics, terpenoids, steroids and essential oils are a large group of plant-derived compounds commonly found in diets high in fruits, vegetables, beans and cereals. Plant remedies are closely linked to the maintenance of good health in the cultural heritage of many countries. Despite the potential benefits to health and performance as noted in various terrestrial animals, the use of phytochemicals in fish farming has rarely been investigated. Fish culture is under pressure to decrease the use of synthetic antibiotics and chemotherapeutics because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. Consequently, efforts are being made to exploit plants, plant extracts or natural plant compounds as potential alternatives to synthetic chemicals for the stimulation of immune responses and disease resistance in fish. The phytochemicals contained in herbs may enhance the innate immune system and possess antimicrobial capabilities that may be of immense use in fish culture without causing any environmental and ⁄ or hazardous problems. Most phytochemicals are redox active molecules that have anti-oxidant characteristics that may improve the general physiological condition of fish. This review discusses the results emanating from different studies related to the in vivo application of plants and ⁄ or phytochemicals in fish in relation to immunostimulation, antipathogenic and antistress activities. Special emphasis is given to the use of Chinese and Indian herbs as immunostimulants in different finfish species during culture and as antibacterial agents against Aeromonas hydrophila.

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“…Water‐soluble seaweed extracts modulate the respiratory burst activity of turbot phagocytes (Castro, Zarra & Lamas 2004). Resveratrol modulates innate and inflammatory responses in fish leucocytes (Castro, Lamas, Morais, Sanmartín, Orallo & Leiro 2008). Chinese herbs ( Astragalus membranaceus and Lonicera japonica ) enhance the non‐specific immune response of Nile tilapia and resistance against Aeromonas hydrophila (Ardó, Yin, Xu, Váradi, Szigeti, Jeney & Jeney 2008).…”

Section: Feeding Rate and Starvationmentioning

confidence: 99%

Nutrition and immunity: an update

Trichet¹

2010

Aquaculture Research

228

115

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Immunity encompasses all mechanisms and responses used by the organism to defend itself against bacteria, viruses or parasites. Adequate supply and balance of nutrients are required for proper e⁄ciency of the host defences. Research has identi¢ed dietary factors that a¡ect human and animal immune responses like amino acids, fatty acids, minerals and vitamins. Some of these nutrients have been proven to have speci¢c actions on immunity when provided at pharmacological doses. This paper will review these nutrients and their current use in aquaculture. The immune system is an e⁄cient but complex system. Its complexity has made the assessment of the e¡ects of diets di⁄cult. Nevertheless, the standardization of methodology as well as the use of new techniques at the cell or the gene level should help to better understand the mechanisms of immune modulation. This paper will review the major functions of ¢sh and shrimp immune system and the methodologies used. Cellular and humoral functions including cytokines will be discussed in relation to potential means to modulate them and the underlying mechanism. A better understanding of the mechanisms of modulation of the immune functions should help in the discovery of new dietary factors to improve the immune status of the animal, leading to better disease resistance.

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Resveratrol modulates innate and inflammatory responses in fish leucocytes

Cited by 43 publications

References 43 publications

Growth parameters, innate immune response and resistance toListonella(Vibrio)anguillarumofDicentrarchus labraxfed carvacrol supplemented diets

Growth parameters, innate immune response and resistance toListonella(Vibrio)anguillarumofDicentrarchus labraxfed carvacrol supplemented diets

Application of phytochemicals as immunostimulant, antipathogenic and antistress agents in finfish culture

Nutrition and immunity: an update

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