Resveratrol mitigate structural changes and hepatic stellate cell activation in N′-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage

Ahmad, Aqil; Ahmad, Riaz

doi:10.1016/j.cbi.2014.07.007

Cited by 78 publications

(59 citation statements)

References 59 publications

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“…Carbon tetrachloride (CCl 4 )-intoxication is a common animal model for studying the mechanism of liver injury as well as hepatoprotective activity of natural and synthetic compounds [3]. There is increasing evidence to suggest that the antioxidant properties of food phenolics is beneficial to liver health, including protection against chemically-induced hepatotoxicity [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Domitrović

Rashed

Cvijanović

et al. 2015

Chemico-Biological Interactions

176

104

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Section: Introductionmentioning

confidence: 99%

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Domitrović

Rashed

Cvijanović

et al. 2015

Chemico-Biological Interactions

176

104

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“…Several studies have shown RSVmediated mitigating effects on markers of hepatic fibrosis (Chan et al 2011;Chávez et al 2008;Di Pascoli et al 2013;Lee et al 2010) and HSC activation ( Fig. 1Z; Ahmad and Ahmad 2014;Di Pascoli et al 2013;Godichaud et al 2000;Souza et al 2008).…”

Section: Resveratrol Inhibits Ethanol-induced Liver Oxidative Stress mentioning

confidence: 98%

Dual effect of red wine on liver redox status: a concise and mechanistic review

2015

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Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.

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“…The inhibition of fibrotic transdifferentiation of HSC by RES was also established in an in vivo rat model in which hepatic fibrosis was induced by N'-nitrosodimethylamine (NDMA) (22). In this model system, the supplementation with RES subsequent to NDMA administration restored liver architecture, prevented oxidative damage, and blocked expression of fibrotic marker genes in HSC (22).…”

Section: Inhibition Of Hepatic Stellate Cell Activationmentioning

confidence: 99%

Resveratrol: Is It Really Good for Liver Health?

Weiskirchen¹,

Weiskirchen²

2017

Hepat Mon

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Context: Resveratrol is a natural occurring stilbene present in a limited number of dietary food products and beverages. It is assumed that resveratrol has health-promoting effects by lowering low-density lipoprotein (LDL) cholesterol, improving microcirculation, and inhibiting platelet aggregation. Altogether, these beneficial effects lower the risk of cardiovascular disease. The "French paradox" assumes that a diet with moderate consumption of red wine lowers the risk of cancer and cardiovascular disease. Based on its healthful activities, a large number of studies were performed during the last decades investigating potential biological effects of resveratrol on liver homeostasis and its potential application as a hepatoprotective drug. Objectives: The current study aimed at discussing the proposed therapeutic attributes of resveratrol on liver health and its postulated mode of activity. Evidence Acquisition: To conduct the current study, the PubMed full-text archive depository for articles presenting data on resveratrol in liver health and disease was searched. Results: Out of the 9268 published articles on resveratrol, a total of 742 articles focused on liver. Among them, 352 articles investigated potential therapeutic activities. Although some of the reported in vitro and in vivo benefits of resveratrol were highly encouraging, well-designed clinical studies were missing. Conclusions: Presently, it is still premature to advise nutritional supplementation of resveratrol to cure hepatic diseases. Moreover, uncritical recommendation to drink wine as a liver health-promoting beverage should be avoided.

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Resveratrol mitigate structural changes and hepatic stellate cell activation in N′-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage

Cited by 78 publications

References 59 publications

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Dual effect of red wine on liver redox status: a concise and mechanistic review

Resveratrol: Is It Really Good for Liver Health?

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