Resveratrol-loaded proniosomes: Formulation, characterization and fortification

Shruthi, P.; Pushpadass, Heartwin A.; Franklin, Magdaline Eljeeva Emerald; Battula, Surendra Nath; Naik, N. Laxmana

doi:10.1016/j.lwt.2020.110127

Cited by 20 publications

(8 citation statements)

References 36 publications

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“…It is reasonable to believe that RSV's molecular structure has not changed and that it will act normally in encapsulated forms. RSV had been successfully encapsulated, as evidenced by the small changes in intensity [78].…”

Section: Fourier Transform Infrared (Ft-ir) Spectroscopy Analysismentioning

confidence: 98%

Nanospanlastics as a Novel Approach for Improving the Oral Delivery of Resveratrol in Lipopolysaccharide-Induced Endotoxicity in Mice

et al. 2023

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Purpose Resveratrol (RSV) is a natural polyphenolic compound that has numerous biological effects. Owing to its poor bioavailability, only trace concentrations of RSV could be found at the site of action. Therefore, the present study was aimed at developing RSV-loaded nanospanlastics to improve its oral delivery and therapeutic activity. Methods RSV-loaded nanospanlastics were prepared using the thin film hydration technique. The developed formulations were characterized via vesicular size (VS), polydispersity index (PDI), zeta potential (ZP) measurements, fourier transform infrared (FT-IR) spectroscopy analysis and transmission electron microscopy (TEM). In vitro release profile was carried out using dialysis bag diffusion technique. In vivo study was carried out using lipopolysaccharide (LPS)-induced endotoxicity model in mice to evaluate the formulations activity. Results The results revealed the successful development of RSV-loaded nanospanlastics which exhibited EE% ranging from 45 to 85%, particle sizes ranging from 260.5 to 794.3 nm; negatively charged zeta potential (≤ − 20 mV) and TEM revealed their spherical shape. An in vitro release study showed biphasic pattern with sustained release of drug up to 24 h. In vivo results showed the superiority of RSV-loaded nanospanlastics over conventional niosomes in attenuating serum levels of liver and kidney functions (aspartate transaminase (AST), alanine transaminase (ALT), and creatinine) in LPS-induced endotoxic mice. Furthermore, both of them suppressed the elevated oxidative stress and inflammatory markers (malondialdehyde (MDA), nitric oxide (NO), and interleukin-1beta (IL-1β)) estimated in the liver and kidney tissues. However, the nanospanlastics showed a prevalence effect over conventional niosomes in kidney measurements and the histopathological examinations. Conclusions These findings reveal the potential of nanospanlastics in improving the oral delivery and therapeutic efficacy of RSV.

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Section: Fourier Transform Infrared (Ft-ir) Spectroscopy Analysismentioning

confidence: 98%

Nanospanlastics as a Novel Approach for Improving the Oral Delivery of Resveratrol in Lipopolysaccharide-Induced Endotoxicity in Mice

et al. 2023

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“…Blocked resveratrol has a stable release and is more stable in the stomach and intestines. 170 Similar to CD, maltodextrin can be modified for better performance. Compared to CD, maltodextrin is cheaper and better soluble in water.…”

Section: Cyclodextrin and Types Of Cyclodextrinsmentioning

confidence: 99%

Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends

Bahavarnia,

Hasanzadeh,

Bahavarnia

et al. 2024

RSC Adv.

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“…They studied their influence on the textural properties of the yoghurt and concluded that the addition of resveratrol-loaded niosomes did not cause changes in its textural properties. Shruthi et al 115 produced resveratrol-loaded proniosomes and tested them in milk and yoghurt. The incorporation of resveratrol-loaded niosomes in milk and yoghurt did not affect the organoleptic qualities of the products.…”

Section: Food Applicationsmentioning

confidence: 99%

Recent advances in oral delivery systems of resveratrol: foreseeing their use in functional foods

Silva,

Gonçalves,

Pastrana

et al. 2023

Food Funct.

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Resveratrol-loaded proniosomes: Formulation, characterization and fortification

Cited by 20 publications

References 36 publications

Nanospanlastics as a Novel Approach for Improving the Oral Delivery of Resveratrol in Lipopolysaccharide-Induced Endotoxicity in Mice

Nanospanlastics as a Novel Approach for Improving the Oral Delivery of Resveratrol in Lipopolysaccharide-Induced Endotoxicity in Mice

Advancements in application of chitosan and cyclodextrins in biomedicine and pharmaceutics: recent progress and future trends

Recent advances in oral delivery systems of resveratrol: foreseeing their use in functional foods

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