Resveratrol: Latest Scientific Evidences of its Chemical, Biological Activities and Therapeutic Potentials

Saad, Nur Mursyida; Sekar, Mahendran; Gan, Siew Hua; Lum, Pei Teng; Vaijanathappa, Jaishree; Ravi, Subban

doi:10.5530/pj.2020.12.240

Cited by 10 publications

(7 citation statements)

References 102 publications

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“…In its 13 C-NMR spectrum [65], α-viniferin exhibited forty-two signals, out of which six methine aliphatic carbon signals appeared between δ 46.4 and 95.6, twelve aromatic -CH groups appeared between δ 96.9 and 128.66, and a total of eighteen quaternary aromatic carbon atoms appeared between δ 118.0 and 161.7, including nine signals assigned to quaternary aromatic carbons under oxygen functions. The 1 H-NMR spectrum exhibited three pairs of doublets for vicinally coupled methine protons at δ 3.97 (H a ) and 6.07 (H g ), 4.61 (H b , J = 6.4 Hz), 4.90 (H d , J = 6.4 Hz), 4.71 (H c , J = 9.7 Hz) and 5.95 (H e , J = 9.7 Hz).…”

Section: Trans-ε-viniferinmentioning

confidence: 99%

“…Furthermore, one of the major products of resveratrol-derived dehydrodimers is called δ-viniferin [8,9]. The δ-viniferin form is an isomer of ε-viniferin [10], which is also a dimer of resveratrol, extracted from Vitis vinifera; it has been extensively investigated for its potential benefits for human health [11][12][13]. Other oligomer stilbenoids that can be extracted and are found in the roots of Vitis vinifera are the resveratrol tetramers, R2-viniferin (Vitisin A) and R-viniferin (Vitisin B), which may mediate some other important biological activities [14].…”

Section: Introductionmentioning

confidence: 99%

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Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

et al. 2022

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Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses.

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Section: Trans-ε-viniferinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

et al. 2022

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“…Another important group of phenylpropanoids in grapes are stilbenes, such as resveratrol, which protects grapes from intense UV light. As resveratrol is an antioxidant agent, it has high economic importance, being used in the pharmaceutical and cosmetic industry (Saad et al, 2020). The complete pathway of resveratrol biosynthesis is described and included in the model, but there are many gaps in the biosynthetic pathways of resveratrol derivatives, such as viniferins, which are not included in the model but are important for wine flavor and aroma.…”

Section: Specialized Metabolic Pathwaysmentioning

confidence: 99%

“…In addition, grapes have other purposes, being marketed as fresh and dried fruits, and used for juice production. The grape pulp contains high levels of sugars and phenolic compounds, like flavonoids and stilbenes, with potential health benefits, such as antioxidant and anti-inflammatory activities, and cardiovascular protection (Saad et al, 2020), thus being currently studied for possible pharmaceutical and cosmetic applications. Therefore, as grapevines have high economic interest and fruit quality is intrinsically linked to metabolism, the study of grapevine metabolism is essential for understanding its responses to different environmental conditions that may affect grape metabolic composition.…”

Section: Introductionmentioning

confidence: 99%

A diel multi-tissue genome-scale metabolic model ofVitis vinifera

Sampaio,

Rocha,

Dias

2024

Preprint

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Vitis vinifera, also known as grapevine, is widely cultivated and commercialized, particularly to produce wine. As wine quality is directly linked to fruit quality, studying grapevine metabolism is important to understand the processes underlying grape composition. Genome-scale metabolic models (GSMMs) have been used for the study of plant metabolism and advances have been made, allowing the integration of omics datasets with GSMMs. On the other hand, Machine learning (ML) has been used to analyze omics data, and while the combination of ML with GSMMs has shown promising results, it is still scarcely used to study plants. Here, the first GSSM of V. vinifera was reconstructed and validated, comprising 7199 genes, 5399 reactions, and 5141 metabolites across 8 compartments. Tissue-specific models for stem, leaf, and berry of the Cabernet Sauvignon cultivar were generated from the original model, through the integration of RNA-Seq data. These models have been merged into diel multi-tissue models to study the interactions between tissues at light and dark phases. The potential of combining ML with GSMMs was explored by using ML to analyze the fluxomics data generated by green and mature grape GSMMs, helping to understand the factors influencing grape quality at different developmental stages.

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“…Resveratrol (RSV) or 3,5,40-trihydroxystilbene is a natural nonflavonoid polyphenol present in numerous plants. The primary sources of RSV are grapes skin and seeds, but commonly it is also detected in red wines [ 15 ]. RSV consists of two aromatic rings that are connected through a methylenic bridge ( Figure 1 ).…”

Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals in the Mediterranean Diet: Potential Avenues for Breast Cancer Treatment

et al. 2021

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The traditional Mediterranean Diet constitutes a food model that refers to the dietary patterns of the population living in countries bordering the Mediterranean Sea in the early 1960s. A huge volume of literature data suggests that the Mediterranean-style diet provides several dietary compounds that have been reported to exert beneficial biological effects against a wide spectrum of chronic illnesses, such as cardiovascular and neurodegenerative diseases and cancer including breast carcinoma. Among bioactive nutrients identified as protective factors for breast cancer, natural polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs) have been reported to possess antioxidant, anti-inflammatory, immunomodulatory and antitumoral properties. The multiple anticancer mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, antioxidant enzymes and immune responses. This review summarizes the anticancer action of some polyphenols, like resveratrol and epigallocatechin 3-gallate, retinoids and omega-3 PUFAs by highlighting the important hallmarks of cancer in terms of (i) cell cycle growth arrest, (ii) apoptosis, (iii) inflammation and (iv) angiogenesis. The data collected from in vitro and in vivo studies strongly indicate that these natural compounds could be the prospective candidates for the future anticancer therapeutics in breast cancer disease.

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Resveratrol: Latest Scientific Evidences of its Chemical, Biological Activities and Therapeutic Potentials

Cited by 10 publications

References 102 publications

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy

A diel multi-tissue genome-scale metabolic model ofVitis vinifera

Nutraceuticals in the Mediterranean Diet: Potential Avenues for Breast Cancer Treatment

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