Resveratrol: Isolation, and Its Nanostructured Lipid Carriers, Inhibits Cell Proliferation, Induces Cell Apoptosis in Certain Human Cell Lines Carcinoma and Exerts Protective Effect Against Paraquat-Induced Hepatotoxicity

El-gizawy, Heba Abd-Elhady; Ali, Ali; Hussein, Mohammed A.

doi:10.1089/jmf.2019.0286

Cited by 30 publications

(14 citation statements)

References 47 publications

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“…The docking calculations were also consistent with multiple in vitro studies highlighting inhibitory effects of resveratrol and its analogs on colon cancer cell viability in both basal and pro-inflammatory conditions [36][37][38]. docking calculations were also consistent with multiple in vitro studies highlighting inhibitory effects of resveratrol and its analogs on colon cancer cell viability in both basal and pro-inflammatory conditions [36][37][38]. In order to improve our knowledge about the bio-pharmacological properties of the hydroalcoholic extract, colorimetric assays were also performed with the aim to evaluate scavenging/reducing and metal chelating properties (Table 6).…”

Section: Resultssupporting

confidence: 79%

Section: Resultssupporting

confidence: 78%

“…The results of in silico experiments suggest the capability of resveratrol to interact with these enzymes in the micromolar range. The docking calculations were also consistent with multiple in vitro studies highlighting inhibitory effects of resveratrol and its analogs on colon cancer cell viability in both basal and pro-inflammatory conditions [36][37][38]. docking calculations were also consistent with multiple in vitro studies highlighting inhibitory effects of resveratrol and its analogs on colon cancer cell viability in both basal and pro-inflammatory conditions [36][37][38].…”

Section: Resultssupporting

confidence: 78%

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Antimicrobial, Antioxidant, and Antiproliferative Effects of Coronilla minima: An Unexplored Botanical Species

et al. 2020

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Coronilla species, belonging to the Coronilla genus (Fabaceae), have long been used in traditional medicine for treating cold, diabetes, pain, and as cardiotonics. The goal of the present study was to explore the phytochemical composition and pharmaco-toxicological properties of C. minima. In this regard, phenolic content, scavenging/reducing properties and antimicrobial activity toward pathogen bacterial (Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus) and fungal strains (Candida albicans, C. tropicalis, Aspergillus tubigensis and A. minutus) were investigated. Extract effects on human colon cancer HCT116 cell viability were also assayed. Finally, a bioinformatics approach was conducted with the aim to identify putative microbial and human protein targets underlying antibacterial, antimycotic, and antiproliferative effects. Phytochemical investigation suggested that water extract is richer in terms of total flavonoid and phenol content, whereas the hydroalcoholic extract was revealed to be more potent as antioxidant agent. According to bioinformatics analysis, the antibacterial activity of the hydroalcoholic extract could be related to its content in resveratrol. The presence of resveratrol could also explain the hydroalcoholic extract efficacy in reducing HCT116 cell viability. In conclusion, the present study represents the first phytochemical and bio-pharmacological investigation about C. minima. Like other plants belonging to the Fabaceae family, C. minima revealed a good source of resveratrol, which could explain, albeit partially, the efficacy of the hydroalcoholic extract as antimicrobial, antioxidant, and antiproliferative agent.

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Section: Resultssupporting

confidence: 79%

Section: Resultssupporting

confidence: 78%

Section: Resultssupporting

confidence: 78%

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Antimicrobial, Antioxidant, and Antiproliferative Effects of Coronilla minima: An Unexplored Botanical Species

et al. 2020

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“…The absorbance was read at 570 nm using a microplate reader. Furthermore, the "GraphPad Prism" and "ne-site total binding" algorithm programs were used to calculate 50% inhibition of viability (IC 50 ) [17,18].…”

Section: In Vitro Cytotoxicity Studiesmentioning

confidence: 99%

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

Gündoğdu

Ekinci

et al. 2022

Nanomaterials

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Imatinib (IMT) is a tyrosine kinase enzyme inhibitor and extensively used for the treatment of gastrointestinal stromal tumors (GISTs). A nanostructured lipid carrier system (NLCS) containing IMT was developed by using emulsification–sonication methods. The characterization of the developed formulation was performed in terms of its particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, loading capacity, sterility, syringeability, stability, in vitro release kinetics with mathematical models, cellular uptake studies with flow cytometry, fluorescence microscopy and cytotoxicity for CRL-1739 cells. The particle size, PDI, loading capacity and zeta potential of selected NLCS (F16-IMT) were found to be 96.63 ± 1.87 nm, 0.27 ± 0.15, 96.49 ± 1.46% and −32.7 ± 2.48 mV, respectively. F16-IMT was found to be stable, thermodynamic, sterile and syringeable through an 18 gauze needle. The formulation revealed a Korsmeyer–Peppas drug release model of 53% at 8 h, above 90% of cell viability, 23.61 µM of IC50 and induction of apoptosis in CRL-1739 cell lines. In the future, F16-IMT can be employed to treat GISTs. A small amount of IMT loaded into the NLCSs will be better than IMT alone for therapy for GISTs. Consequently, F16-IMT could prove to be useful for effective GIST treatment.

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“…In particular, RSV suppressed nucleocapsid (N) protein expression, leading to the inhibition of MERS-CoV infection. While the biological absorption rate of RSV in clinical trials has been low, the biological efficacy of RSV derivatives and nano-scale RSV are immensely high [ 73 ], implying that RSV effectiveness in the clinical setting may be pronounced following modification.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses

et al. 2021

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Several preclinical and clinical studies have attempted to elucidate the pathophysiological mechanism associated with spinal cord injury. However, investigations have been unable to define the precise related mechanisms, and this has led to the lack of effective therapeutic agents for the condition. Neuroinflammation is one of the predominant processes that hinder spinal cord injury recovery. Resveratrol is a compound that has several biological features, such as antioxidation, antibacterial, and antiinflammation. Herein, we reviewed preclinical and clinical studies to delineate the role of toll-like receptors, nod-like receptors, and astrocytes in neuroinflammation. In particular, the alteration of astrocytes in SCI causes glial scar formation that impedes spinal cord injury recovery. Therefore, to improve injury recovery would be to prevent the occurrence of this process. Resveratrol is safe and effective in the significant modulation of neuroinflammatory factors, particularly those mediated by astrocytes. Thus, its potential ability to enhance the injury recovery process and ameliorate spinal cord injury.

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Resveratrol: Isolation, and Its Nanostructured Lipid Carriers, Inhibits Cell Proliferation, Induces Cell Apoptosis in Certain Human Cell Lines Carcinoma and Exerts Protective Effect Against Paraquat-Induced Hepatotoxicity

Cited by 30 publications

References 47 publications

Antimicrobial, Antioxidant, and Antiproliferative Effects of Coronilla minima: An Unexplored Botanical Species

Antimicrobial, Antioxidant, and Antiproliferative Effects of Coronilla minima: An Unexplored Botanical Species

An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies

Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses

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