Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

Dai, Hui; Deng, Hou-Bo; Wang, Yahong; Guo, Jiajuan

doi:10.3892/ol.2018.8772

Cited by 26 publications

(16 citation statements)

References 14 publications

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“…Analyses on a higher number of samples will be necessary to determine if these molecules can function as markers to predict the patients’ outcome. In addition, since EMILIN-2 modulates the Wnt/β-catenin signaling pathway [37] which affects the behavior of gastric cancer cells [59], the loss of EMILIN-2 expression may also display a direct effect of gastric cancer cell growth and progression. Finally, the analyses of EMILIN-1 revealed that in some cases tumor samples were characterized by an altered organization of the molecule in the lamina propria.…”

Section: Discussionmentioning

confidence: 99%

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

Andreuzzi

Capuano

Pellicani

et al. 2018

IJMS

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Gastric cancer is a deadly tumor and a relatively common disease worldwide. Surgical resection and chemotherapy are the main clinical options to treat this type of disease, however the median overall survival rate is limited to one year. Thus, the development of new therapies is a highly necessary clinical need. Angiogenesis is a promising target for this tumor type, however clinical trials with the use of anti-angiogenic drugs have so far not met expectations. Therefore, it is important to better characterize the expression of molecules whose expression levels may impact on the efficacy of the treatments. In this study the characteristics of the gastric tumor associated blood vessels were first assessed by endomicroscopy. Next, we analyzed the expression of Multimerin-2, EMILIN-2 and EMILIN-1, three molecules of the EMI Domain ENdowed (EDEN) protein family. These molecules play important functions in the tumor microenvironment, affecting cancer progression both directly and indirectly impinging on angiogenesis and lymphangiogenesis. All the molecules were highly expressed in the normal mucosa whereas in a number of patients their expression was altered. We consider that better characterizing the gastric tumor microenvironment and the quality of the vasculature may achieve effective patient tailored therapies.

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Section: Discussionmentioning

confidence: 99%

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

Andreuzzi

Capuano

Pellicani

et al. 2018

IJMS

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“…These results suggest that RSV can behave differently according to the dose used and the cell type and the metabolic state [120]. Recently, Dai et al [128] showed that RSV inhibits the growth and proliferation of MGC-803 cells of gastric cancer in a dose- and time-dependent way by downregulating the expression of genes related with Wnt pathway as β-catenin, c-myc, and cyclin D1, proteins related with GLUTs gene regulation. On the other hand, Kleszcz, et al [129] did not observe inhibition of c-myc gene expression by resveratrol in FaDu hypopharyngeal carcinoma cells, but the doses used were significantly lower.…”

Section: Inhibition Of Glucose Uptake By Resveratrolmentioning

confidence: 99%

“…(d) Regulating GLUT1 expression through various signaling pathways such as: AMPK [147], Wnt [127,128], Jnk kinases [129,130], sirtuins and histone deacetylases [132].…”

Section: Inhibition Of Glucose Uptake By Resveratrolmentioning

confidence: 99%

Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy

Zambrano

Molt

Uribe

et al. 2019

IJMS

148

111

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An important hallmark in cancer cells is the increase in glucose uptake. GLUT1 is an important target in cancer treatment because cancer cells upregulate GLUT1, a membrane protein that facilitates the basal uptake of glucose in most cell types, to ensure the flux of sugar into metabolic pathways. The dysregulation of GLUT1 is associated with numerous disorders, including cancer and metabolic diseases. There are natural products emerging as a source for inhibitors of glucose uptake, and resveratrol is a molecule of natural origin with many properties that acts as antioxidant and antiproliferative in malignant cells. In the present review, we discuss how GLUT1 is involved in the general scheme of cancer cell metabolism, the mechanism of glucose transport, and the importance of GLUT1 structure to understand the inhibition process. Then, we review the current state-of-the-art of resveratrol and other natural products as GLUT1 inhibitors, focusing on those directed at treating different types of cancer. Targeting GLUT1 activity is a promising strategy for the development of drugs aimed at treating neoplastic growth.

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“…Resveratrol has been known to be a biologically-active substance that can treat the diseases including obesity, inflammation, diabetes, and cancers [15,16,17,18]. Resveratrol has been shown to effectively inhibit growth in many types of cancer including breast, gastric, lung, and thyroid cancer [19,20,21,22].…”

Section: Anticancer Effects Of Phytochemicals On Thyroid Cancersmentioning

confidence: 99%

Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

2019

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Thyroid cancers developed from the tissues of the thyroid gland are classified into papillary (PTC), follicular (FTC), medullary (MTC), and anaplastic thyroid cancer (ATC). Although thyroid cancers have been generally known as mild forms of cancer, undifferentiated MTC and ATC have a more unfavorable prognosis than differentiated PTC and FTC because they are more aggressive and early metastatic. A variety of therapies such as surgery, radiotherapy, and chemotherapy have been currently used to treat thyroid cancer, but they still have limitations including drug resistance or unfavorable side effects. Phytochemicals are plant-derived chemicals having various physiological activities that are expected to be effective in cancer treatment. In this review, anticancer efficacy of phytochemicals, such as resveratrol, genistein, curcumin, and other substances in each type of thyroid cancer was introduced with their chemopreventive mechanisms. English articles related with thyroid cancer and anti-thyroid cancer of phytochemicals were searched from PubMed and Google Scholar. This article mainly focused on in vitro or animal studies on phytochemicals with anti-thyroid cancer activity. These various phytochemicals have been shown to induce apoptosis in all types of thyroid cancer cells, inhibit cell proliferation and invasion, and to be helpful in enhancing the effect of radioiodine therapy that is a typical therapy to thyroid cancer. These results suggest that thyroid cancer can be more effectively treated by the combinations of phytochemicals and the existing therapies or substances.

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Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway

Cited by 26 publications

References 14 publications

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis

Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy

Antitumor Effect of Various Phytochemicals on Diverse Types of Thyroid Cancers

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