Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression by suppressing NF-κB activation

Abstract

P. gingivalis is a major pathogen that is involved in the onset and progression of periodontal disease. This study investigated the effect of resveratrol, a naturally occurring polyphenol, on P. gingivalis LPS-accelerated vascular inflammation, a key step in the progression of periodontitis. Resveratrol significantly inhibited the P. gingivalis LPS-induced adhesion of leukocytes to endothelial cells and to the aortic endothelium by down-regulating the cell adhesion molecules, ICAM-1 and VCAM-1. Moreover, the inhibition of the P. gingivalis LPS-induced cell adhesion molecules by resveratrol was mainly mediated by nuclear factor-kappaB (NF-kappaB). Resveratrol suppressed P. gingivalis LPS-stimulated IkappaBalpha phosphorylation and nuclear translocation of the p65 subunit of NF-kappaB in HMECs. Overall, these findings suggest that resveratrol significantly attenuates the P. gingivalis LPS-induced monocyte adhesion to the endothelium by suppressing the expression of the NF-kappaB-dependent cell adhesion molecules, suggesting its therapeutic role in periodontal pathogen-induced vascular inflammation.

A successful experimental model for intimal hyperplasia prevention using a resveratrol-delivering balloon

“…There are several pioneering reports on RSV, including studies on the inhibition of the arachidonate metabolism via interactions with the 5-lipoxygenase and cyclooxygenase pathways in leukocytes [6][7][8][9][10][11][12] . However, RSV attracted little interest until 1979, when the "French Paradox" 13 reported the positive benefit of an RSV-containing diet, in particular the moderate consumption of red wine, for coronary heart disease.…”

The Effect of Resveratrol Supplementation in Adjunct with Non-surgical Periodontal Treatment on Blood Glucose, Triglyceride, Periodontal Status and Some Inflammatory Markers in Type 2 Diabetic Patients with Periodontal Disease

“…The main mechanism suggested for inhibition of LPS by resveratrol is non-activation of the nuclear factor of KB (NF/KB) (26). Sirtuin proteins (SIRT) are thought to improve mitochondrial function and energy limiting, there is a direct relationship between SIRT and the beneficial role of resveratrol including the improvement of glucose metabolism and insulin sensitivity.…”

“…In one study carried out by Nafumi et al, the effects of resveratrol were investigated on Wistar male rats with periodontal disease, and it was shown that resveratrol reduced periodontitis and bone loss, increased antioxidant defense, and improved inflammatory factors; therefore, resveratrol supplementation was recommended for improving periodontal status (47). In a laboratory study in Korea, Joo Park et al (2009) investigated the effect of resveratrol on lipopolysaccharide P. gingivalis, and suggested that resveratrol supplementation may help to remove periodontal pathogens (26).…”

“…Resveratrol may have an antioxidant effect against oxidative stress in some chronic diseases such as diabetes mellitus and cardiovascular diseases (24,26,27). It is assumed that in patients with periodontal disease, there may be a resistance to antibiotics; resveratrol with a strong antimicrobial and anti-inflammatory properties can play an important role in the treatment process.…”

The expediency substantiation of the resveratrol and quercetin polyphenols use in ischemic heart disease combined with autoimmune thyroiditis. Part II

“…Park H.J. и соавторы устано-вили, что экспрессия молекул адгезии ICAM-1 и VCAM-1 на эндотелиоцитах микрососудов чело-века блокируется ресвератролом путем ингибиро-вания активации NF-kB [18].…”