Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells

Kim, Gi‐Young; Cho, Hoon; Ahn, Soon‐Cheol; Oh, Yang-Hyo; Lee, Chang-Min; Park, Yeong‐Min

doi:10.1016/j.intimp.2003.12.009

Cited by 40 publications

(30 citation statements)

References 43 publications

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“…These cytokines may induce the expression of inflammatory molecules in both the endothelial cells of the bronchial circulation and the epithelial cells in the airway, and they may also promote the recruitment of lymphocytes and eosinophils (22). One of these cytokines, IL-4, induces isotype switching from IgG to IgE production in B cells (23).…”

Section: Discussionmentioning

confidence: 99%

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma

Park¹,

Kim²,

Lee³

et al. 2012

BMB Reports

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Section: Discussionmentioning

confidence: 99%

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma

Park¹,

Kim²,

Lee³

et al. 2012

BMB Reports

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“…Additionally, an MMP inhibitor regulated inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma [23]. In our murine model of asthma, intraperitoneally injected mice with 8 mg/kg/day, 16 mg/kg/day Quercetin to evaluate the effect of Quercetin on the expression of MMP-9, T-bet and GATA3 mRNA.…”

Section: Discussionmentioning

confidence: 99%

“…We reported in a previous work that a variety of phytochemicals exhibited profound immunoregulatory activities both in vitro and in vivo, particularly in DCs [23,24]. Dietary intake of tomatoes and tomato products reportedly is associated with decreased risk of cardiovascular disease and several types of cancer, especially prostate cancer [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Quercetin regulates Th1/Th2 balance in a murine model of asthma

Park¹,

Lee²,

Jung³

et al. 2009

International Immunopharmacology

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“…In response to lipopolysaccharide (LPS) stimulation, bone marrow (BM)-derived dendritic cells (DC) produce intracellular IL-12 p40/p70 and secretory IL-12 p70 and resveratrol was found to inhibit these secretions. 106 Gao et al reported that there was a significant suppression (>90%) of the mitogen/antigen- …”

Section: Resveratrol and Immune Systemmentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

481

339

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Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g., NFκB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g., Bcl-2, Bcl-X L , XIAP and survivin), inhibit protein kinases (e.g., src, PI3K, JNK and AKT), induce antioxidant enzymes (e.g., catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomarkers (e.g., TNF, COX-2, iNOS and CRP), inhibit the expression of angiogenic and metastatic gene products (e.g., MMPs, VEGF, cathepsin D and ICAM-1), and modulate cell cycle regulatory genes (e.g., p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential.

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Resveratrol inhibits phenotypic and functional maturation of murine bone marrow-derived dendritic cells

Cited by 40 publications

References 43 publications

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma

Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma

Quercetin regulates Th1/Th2 balance in a murine model of asthma

Resveratrol: A multitargeted agent for age-associated chronic diseases

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