Resveratrol Inhibits Pancreatic Cancer Cell Proliferation Through Transcriptional Induction of Macrophage Inhibitory Cytokine-1

Golkar, Laleh; Ding, Xian; Ujiki, Michael; Salabat, Mohammad R.; Kelly, David L.; Scholtens, Denise M.; Fought, Angela J.; Bentrem, David J.; Talamonti, Mark S.; Adrian, Thomas E.

doi:10.1016/j.jss.2006.05.037

Cited by 67 publications

(32 citation statements)

References 19 publications

(23 reference statements)

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“…In vitro and in vivo studies have shown that the involvement of GDF15 in cell growth inhibition, apoptosis induction, and enhancement of cancer invasiveness is dependent on cancer cell types , Lambert et al 2006, Golkar et al 2007.…”

Section: Discussionmentioning

confidence: 99%

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Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells

Tsui¹,

Chang²,

Feng³

et al. 2012

Journal of Molecular Endocrinology

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Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-b superfamily, is associated with human cancer progress. We evaluated the role GDF15 plays in tumorigenesis of prostate carcinoma PC-3 cells. Results from real-time RT-PCR and ELISA revealed that expression of GDF15 was approximately threefold higher in LNCaP cells than in PC-3 cells. Other prostate cell lines (PZ-HPV-7, CA-HPV-10, and DU145 cells) expressed extremely low levels of GDF15. Stable overexpression of GDF15 in PC-3 cells enhanced the degree of cell proliferation and invasion as shown in the 3 H-thymidine incorporation assay and in the Matrigel invasion assay respectively. Soft agar assays and xenograft animal studies indicated that overexpression of GDF15 in PC-3 cells increased tumorigenesis in vitro and in vivo. Results from RT-PCR, immunoblot, and reporter assays revealed that overexpression of GDF15 resulted in decreased expression of maspin and upregulation of interleukin-6 (IL6), matriptase, and N-myc downstream-regulated gene 1 (NDRG1) expression. Further studies revealed that overexpression of IL6 enhanced GDF15 expression in LNCaP cells while knockdown of IL6 blocked the expression of GDF15 in PC-3 cells, suggesting that expression of GDF15 is upregulated by IL6. This study demonstrated that expression of GDF15 induces cell proliferation, invasion, and tumorigenesis of prostate carcinoma PC-3 cells. The enhancement of tumorigenesis and invasiveness of prostate carcinoma cells that stably overexpress GDF15 may be caused by the dysregulation of maspin, matriptase, and IL6 gene expression. The expression of GDF15 and IL6 is controlled via a positive feedback loop in PC-3 cells.

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Section: Discussionmentioning

confidence: 99%

“…The major function of GDF15 is not completely understood. Studies have shown that GDF15 is involved in the inhibition of cell growth, induction of apoptosis, and enhancement of cancer invasiveness in different cancer cell lines , Kadara et al 2006, Lambert et al 2006, Golkar et al 2007.…”

Section: Introductionmentioning

confidence: 99%

Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells

Tsui¹,

Chang²,

Feng³

et al. 2012

Journal of Molecular Endocrinology

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“…Res inhibits tumor cell proliferation by reducing the number of G-phase cells and blocking S-phase cells (15). Res shows a bidirectional effect on the cell proliferation of prostate, breast, pancreatic and esophageal cancer, namely, a low concentration of Res promotes cell growth while a high concentration inhibits the growth (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation

Liu

Yang

2012

Oncology Letters

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Abstract. The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 µmol/l) for various times (24, 48 and 72 h). The inhibitory effect of Res on U20S proliferation was observed using methyl thiazolyl tetrazolium (MTT) colorimetry. VEGF expression was determined using real-time polymerase chain reaction (RT-PCR) and western blot analysis. The inhibitory effect of Res on U20S proliferation increased as the concentration of Res increased. The inhibitory effect also increased with time. Res had an inhibitory effect on VEGF expression and significantly inhibited U20S cell proliferation. Res may exert an anti-osteosarcoma effect by inhibiting VEGF expression in tumor cells.

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“…It has pro-apoptotic and anti-tumorigenic activities in cancer cell lines. Its overexpression led to a decrease in tumor size [25]. Recently, studies regarding its role in mortality, obesity and heart diseases have also been reported [2,3,4,5].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Validity of Serum Macrophage Inhibitor Cytokine and Tissue Polypeptide-Specific Antigen in Pancreatobiliary Diseases

Özkan¹,

Demirbaş

İbi̇ş

et al. 2011

Pancreatology

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Resveratrol Inhibits Pancreatic Cancer Cell Proliferation Through Transcriptional Induction of Macrophage Inhibitory Cytokine-1

Cited by 67 publications

References 19 publications

Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells

Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells

Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation

Diagnostic Validity of Serum Macrophage Inhibitor Cytokine and Tissue Polypeptide-Specific Antigen in Pancreatobiliary Diseases

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