Resveratrol inhibits migration and invasion of human breast‐cancer cells

Tang, Feng‐Yao; Su, Yu-Ching; Chen, Nai-Chia; Hsieh, Hui‐Shan; Chen, Kaun-Suei

doi:10.1002/mnfr.200700325

Cited by 74 publications

(47 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are lots of evidence suggesting that resveratrol can inhibit cell migration and invasion under normoxia and but its mechanisms are poorly understood [34,35]. In this study, we found resveratrol also showed similar effect under hypoxia.…”

Section: Discussionsupporting

confidence: 56%

Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis

Wang¹,

Han²,

Zhang³

2016

neo

View full text Add to dashboard Cite

Hypoxia promotes aggressiveness, angiogenesis and resistance in glioma. It has been reported that resveratrol has strong anti-tumor ability and can inhibit migration and invasion of varieties of tumor including glioma. However, whether resveratrol inhibits hypoxia-induced migration and invasion of glioma cells is still unknown. In this study, we found glioma U87 and U251 cells migration and invasion was reduced by resveratrol under hypoxia condition and higher doses led to stronger block, while proliferation of U87 and U251 cells was hardly effected. Mechanically, hypoxia-induced upregulation of phosphorylated signal transducer and activator of transcription 3(p-STAT3) was blocked by resveratrol. MicroRNA-34a (miR-34a) is a tumor suppressor whose promoter region has a conserved STAT3-binding site and can be negatively regulated by STAT3. Interestingly, miR-34a was downregulated under hypoxia but upregulated by resveratrol which was perhaps relevant to changes in level of p-STAT3. The effect of resveratrol on p-STAT3 and miR-34a was both time-and dose-dependent. Summarizing, resveratrol inhibits hypoxia-induced migration and invasion possibly via p-STAT3/miR-34a axis and this effect is both time-and dose-dependent.

show abstract

Section: Discussionsupporting

confidence: 56%

Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis

Wang¹,

Han²,

Zhang³

2016

neo

View full text Add to dashboard Cite

show abstract

“…Resveratrol has been shown to inhibit migration and invasion of human breast cancer cells (39). Resveratrol was previously reported to protect cells from oxidative DNA damage caused by hydrogen peroxide and peroxynitrite (40).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells

Gweon

Kim

2012

Oncology Reports

View full text Add to dashboard Cite

Abstract. 4', is a grape polyphenol present in various plants, food products, red wine and grapes. Resveratrol has anti-inflammatory, anticarcinogenic, anti-oxidant and anti-aging properties. Matrix metalloproteinases (MMPs) are key enzymes involved in the degradation of the extracellular matrix, and their expression may be regulated in cancer metastasis. In the present study, we aimed to evaluate the effect of resveratrol on MMPs and cell migration, and to understand the mechanism of action in HT1080 human fibrosarcoma cells. We found that resveratrol inhibited HT1080 cell viability at various concentrations as detected by the MTT assay and FACS analysis. However, resveratrol dramatically increased the activation and expression of MMP-9 in a dose-and time-dependent manner, as determined by gelatin zymography assay and western blot analysis. We also discovered that resveratrol enhanced the migratory ability of HT1080 cells, as determined by the wound healing assay, and decreased the phosphorylation of p38 kinase. Moreover, the Akt kinase was inhibited by resveratrol in the HT1080 cells. The inhibition of p38 and Akt kinases with SB203580 and LY294002 further increased resveratrol-induced MMP-9 as well as cell migration in the HT1080 cells. Our results suggest that resveratrol regulates MMP-9 and migratory abilities through the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells.

show abstract

“…HRG-1 signaling through the HER2/neu receptor results in induction of MMP-9 (Ocharoenrat et al, 1999;Tsai et al, 2003). Additionally, resveratrol has been shown to inhibit the expression of MMP-2 induced by insulin-like growth factor 1 (IGF-1) (Tang et al, 2008b).…”

Section: Resveratrolmentioning

confidence: 99%