Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function

Zhang, Yuming; Yuan, Fengyu; Li, Pei; Gu, Jihai; Han, Junjun; Ni, Zhihua; Liu, Fengsong

doi:10.1016/j.ecoenv.2022.113788

Cited by 10 publications

(10 citation statements)

References 49 publications

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“…Previous studies have reported that RES induces reactive oxygen species (ROS) overproduction in tumor cells (W. Li et al, 2020; Rodriguez‐Enriquez et al, 2019; Y. Zhang et al, 2022), including lung cancer cells. To further clarify the underlying mechanisms of RES in lung cancer, we measured ROS production after concentration‐ and time‐dependent RES treatment in A549 and H1299 cells.…”

Section: Resultsmentioning

confidence: 99%

“…At the same time, other studies have also identified a pro‐oxidant effect of RES on other cancer cells (Blanquer‐Rossello et al, 2017; Costa et al, 2022). Previous studies have reported that depending on the cell type, concentration, and time of exposure, RES might exert pro‐oxidant or antioxidant properties (de la Lastra & Villegas, 2007; Y. Zhang et al, 2022), which makes it different from other anticancer compounds. Pro‐oxidant action could be a common mechanism for the anticancer properties of plant polyphenols.…”

Section: Discussionmentioning

confidence: 99%

“…Lastra & Villegas, 2007; Y. Zhang et al, 2022), which makes it different from other anticancer compounds. Pro-oxidant action could be a common mechanism for the anticancer properties of plant polyphenols.…”

Section: Discussionmentioning

confidence: 99%

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Destruction of the cellular antioxidant pool contributes to resveratrol‐induced senescence and apoptosis in lung cancer

Liang

Zhou

et al. 2023

Phytotherapy Research

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Resveratrol (RES) has various pharmacological bioactivities and its anticancer effects in lung cancer have been proven. However, the underlying mechanisms of action of RES in lung cancer remain unclear. This study focused on Nrf2-mediated antioxidant systems in RES-treated lung cancer cells. A549 and H1299 cells were treated with various concentrations of RES at different times. RES decreased cell viability, inhibited cell proliferation, and increased the number of senescent and apoptotic cells in a concentration-and time-dependent manner. Moreover, RES-induced lung cancer cell arrest at the G1 phase was accompanied by changes in apoptotic proteins (Bax, Bcl-2, and cleaved caspase 3). Furthermore, RES induced a senescent phenotype along with changes in senescence-related markers (senescence-associated β-galactosidase activity, p21, and p-γH2AX). More importantly, with prolonged exposure time and increased exposure concentration, intracellular reactive oxygen species (ROS) continuously accumulated, resulting in a decrease in Nrf2 and its downstream antioxidant response elements, including CAT, HO-1, NQO1, and SOD1. Meanwhile, RES-induced ROS accumulation and cell apoptosis were reversed by N-acetyl-Lcysteine treatment. Taken together, these results suggest that RES disturb lung cancer cellular homeostasis by destroying the intracellular antioxidant pool to increase ROS production. Our findings provide a new perspective on RES intervention in lung cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Destruction of the cellular antioxidant pool contributes to resveratrol‐induced senescence and apoptosis in lung cancer

Liang

Zhou

et al. 2023

Phytotherapy Research

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“…109 A recent study showed that resveratrol could reduce MMP and mtDNA copy number and then activate autophagy, indicating mitochondrial damage. 110 Mitochondrial damage was also suggested by inhibited respiratory capacities observed in the study (Figure 4). Pterostilbene is a dimethoxylated analog of resveratrol and can be naturally found in blueberries and almonds.…”

Section: Phytochemicals Impair Mitochondria To Achieve Cancer Preventionmentioning

confidence: 99%

“…Early in the year 2011, it was reported that resveratrol could promote the interaction of X-linked inhibitor of apoptosis protein (XIAP) and Bax, which initiates Bax translocation and oligomerization onto the mitochondrial membrane; this leads to cytochrome c release, followed by activation of the caspase-9 cascade (Figure ). A recent study showed that resveratrol could reduce MMP and mtDNA copy number and then activate autophagy, indicating mitochondrial damage . Mitochondrial damage was also suggested by inhibited respiratory capacities observed in the study (Figure ).…”

Section: Phytochemicals Induce Mitochondrial Dysfunction In Cancermentioning

confidence: 99%

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

Koh

Pan

2023

J. Agric. Food Chem.

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Mitochondrial dysfunction may cause cell death, which has recently emerged as a cancer prevention and treatment strategy mediated by chemotherapy drugs or phytochemicals. However, most existing drugs cannot target cancerous cells and may adversely affect normal cells via side effects. Mounting studies have revealed that phytochemicals such as resveratrol could ameliorate various diseases with dysfunctional or damaged mitochondria. For instance, resveratrol can regulate mitophagy, inhibit oxidative stress and preserve membrane potential, induce mitochondrial biogenesis, balance mitochondrial fusion and fission, and enhance the functionality of the electron transport chain. However, there are only a few studies suggesting that phytochemicals could potentially protect against the cytotoxicity of some current cancer drugs, especially those that damage mitochondria. Besides, COVID-19 and long COVID have also been reported to be correlated to mitochondrial dysfunction. Curcumin has been reported bringing a positive impact on COVID-19 and long COVID. Therefore, in this study, the benefits of resveratrol and curcumin to be applied for cancer treatment/prevention and disease amelioration were reviewed. Besides, this review also provides some perspectives on phytochemicals to be considered as a treatment adjuvant for COVID-19 and long COVID by targeting mitochondrial rescue. Hopefully, this review can provide new insight into disease treatment with phytochemicals targeting mitochondria.

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Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria

Wang

Lin

Zhuo

et al. 2023

European Journal of Medicinal Chemistry

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Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function

Cited by 10 publications

References 49 publications

Destruction of the cellular antioxidant pool contributes to resveratrol‐induced senescence and apoptosis in lung cancer

Destruction of the cellular antioxidant pool contributes to resveratrol‐induced senescence and apoptosis in lung cancer

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria

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